Article
Plant Sciences
Mengjiali Wei, Jiayan Su, Qian Ma, Fang Zhang, Jing Wang, Liang Feng, Xiaobin Jia, Xiaobin Tan
Summary: Erteng Tongbi Decoction can significantly improve collagen-induced arthritis by modulating T cell differentiation and cytokines balance. It contains various active constituents.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Morteza Saeedavi, Mehdi Goudarzi, Saeed Mehrzadi, Zahra Basir, Ali Hasanvand, Azam Hosseinzadeh
Summary: This study evaluated the effects of Sinapic acid (SA) on a murine model of ovalbumin-induced allergic asthma. The results showed that SA significantly inhibited inflammatory cell infiltration, enhanced interferon-gamma production, and decreased interleukin levels. Additionally, SA reduced serum immunoglobulin E levels and showed anti-inflammatory effects on lung tissue. Overall, SA may have potential as a therapeutic agent for treating allergic asthma.
Article
Pharmacology & Pharmacy
Wei Zhe, Naomi Hoshina, Yukihiro Itoh, Toshifumi Tojo, Takayoshi Suzuki, Koji Hase, Daisuke Takahashi
Summary: This study evaluated the therapeutic effect of a novel selective HDAC1 inhibitor TTA03-107 in arthritis models and found that it can attenuate the severity of autoimmune arthritis. The results demonstrate that TTA03-107 can slow down the development of arthritis by inhibiting the differentiation and activation of macrophages and Th17 cells.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2022)
Article
Biochemistry & Molecular Biology
Ju-Eun Hong, Chang-Gun Lee, Soonjae Hwang, Junyoung Kim, Minjeong Jo, Da-Hye Kang, Sang-Hyeon Yoo, Woo-Seung Kim, Yongheum Lee, Ki-Jong Rhee
Summary: This study found that pulsed electromagnetic field (PEMF) can alleviate inflammation in rheumatoid arthritis (RA), particularly at a frequency of 10 Hz. The treated mice had lower levels of joint inflammation and IL-1 beta. The results suggest that PEMF treatment can preserve joint morphology and delay the occurrence of RA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Jing He, Yanan Chu, Jing Li, Qingren Meng, Yudong Liu, Jiayang Jin, Yifan Wang, Jian Wang, Bo Huang, Lianjie Shi, Xing Shi, Jiayi Tian, Yunzhi Zhufeng, Ruiling Feng, Wenjing Xiao, Yuzhou Gan, Jianping Guo, Changjun Shao, Yin Su, Fanlei Hu, Xiaolin Sun, Jun Yu, Yu Kang, Zhanguo Li
Summary: This study reveals the imbalance between butyrate-producing and butyrate-consuming species in rheumatoid arthritis patients. It shows that butyrate promotes the production of T-regs and reduces inflammation. Butyrate supplementation can alleviate inflammation by rebalancing immune cells and reducing antibody production.
Article
Biochemistry & Molecular Biology
Diana Guimaraes, Franck Lager, Gilles Renault, Jamil Guezguez, Michael Burnet, Joana Cunha, Artur Cavaco-Paulo, Eugenia Nogueira
Summary: Methotrexate (MTX) is commonly used as a first-line therapy for rheumatoid arthritis (RA), but its side effects can limit its use. Folate-targeted liposomal formulation of MTX (FL-MTX) is a modified nanotherapeutic treatment that has shown good therapeutic efficacy in a mouse model of collagen-induced arthritis (CIA). FL-MTX can reduce the hepatic and renal elimination of MTX, leading to a potential reduction in treatment frequency and overall dosage.
Article
Environmental Sciences
Jinlong Li, Yuanyuan Guo, Xiaoxu Duan, Bing Li
Summary: Inorganic arsenic induces immune tolerance in murine dendritic cells by down-regulating the expression of phenotypic molecules, pro-inflammatory factors, and T-lymphocyte cytokines. The immunosuppressive property of arsenic may be partially mediated by the HO-1 pathway, contributing to the development of infections and malignant diseases.
Article
Immunology
Alexis M. Crockett, Hania Kebir, Nail Benallegue, Philippa Adelman, Raquel E. Gur, Kathleen Sullivan, Stewart A. Anderson, Jorge I. Alvarez
Summary: Research shows that T cell counts in 22qDS patients are deficient in infancy, but can be normalized by adulthood. Additionally, the 22q11.2 deletion does not affect T cell differentiation or activity.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Review
Cell & Tissue Engineering
P. Luo, P. Wang, J. Xu, W. Hou, P. Xu, K. Xu, L. Liu
Summary: Rheumatoid arthritis is an autoimmune disease involving T and B cells and their interactions with proinflammatory cytokines. T cells, including Th1, Th2, Th17, and Tfh cells, play important roles in RA by secreting different cytokines and promoting joint destruction and disease progression.
BONE & JOINT RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Jian Lu, Jing Wu, Xueli Xia, Huiyong Peng, Shengjun Wang
Summary: RA is a chronic autoimmune disease characterized by joint and systemic inflammation, with Tfh cells playing a crucial role in the pathogenesis of the disease and affecting disease activity.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jae Wook Jung, Ae Rin Lee, Jaesung Kim, Young Rim Kim, Jassy Mary S. Lazarte, Jung Suk Lee, Kim D. Thompson, Hyeongsu Kim, Tae Sung Jung
Summary: The study successfully generated monoclonal antibodies against CD8 T lymphocytes in olive flounder and confirmed their specificity. The populations of CD4 and CD8 T lymphocytes significantly increased in fish infected or immunized, with up-regulation of Th1-related genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Jian Yang, Ya-rong Lin, Bo -jun Xiong, Ze-hong Chen, Yu-fei Luo, Ying Xu, Yan-ping Su, Hui-hui Huang, Chang-xi Yu
Summary: Koumine, an alkaloid, has therapeutic effects against rheumatoid arthritis (RA) and may restore the homeostasis of Th subsets and cytokines by inhibiting T cell activation, subsequently regulating the polarization of Th subsets and the downstream imbalance of pro/anti-inflammatory cytokines in RA.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Cell Biology
Piaopiao Pan, Miguel A. Pineda, Yilin Wang, Aneesah Khan, Mukanthu H. Nyirenda
Summary: CD20+ T cells are an inflammatory subset involved in autoimmune diseases, including rheumatoid arthritis (RA). In this study, we examined the characteristics of the CD20+ T cell subset in a murine model of RA and investigated the phenotype and function of CD3+CD20+ T cells in the lymph nodes and arthritic joints. We found that CD3+CD4+CD20+ and CD3+CD8+CD20+ T cells were expanded in the draining lymph nodes of the RA model, produced higher levels of pro-inflammatory cytokines, and were less regulated by regulatory T cells. These CD20+ T cells were also enriched with T follicular helper cells and peripheral T helper cells, which are involved in promoting B-cell responses and antibody production within inflamed non-lymphoid tissues in RA. Our findings suggest that CD20+ T cells contribute to inflammatory responses and may worsen pathology by promoting inflammatory B-cell responses.
CELLULAR IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yeon-Hwa Park, You-Jin Jang, Yongseok Choi, Kyeong Lee, Hee Jung Kim, Okki Cho, Hae-Ri Lee, Tae-Hwe Heo
Summary: The combination treatment of LMT-28 and metformin significantly improves arthritic symptoms in CIA by suppressing Th17 differentiation and IL-6 signaling.
Article
Immunology
Teng Li, Xiaoying Liu, Peng Han, Alimu Aimaier, Yaosheng Zhang, Jinyao Li
Summary: Syringaldehyde (SD), a flavonoid polyphenolic compound, has shown antioxidant and anti-inflammatory properties and can modulate dendritic cells (DCs) to treat rheumatoid arthritis (RA). SD down-regulates CD86, CD40, and MHC II expression, decreases TNF-α, IL-6, IL-12p40, and IL-23 secretion, increases IL-10 secretion, promotes antigen phagocytosis, and inhibits MAPK/NF-κB signaling pathways in DCs, thereby alleviating arthritis symptoms.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
