Journal
MODERN RHEUMATOLOGY
Volume 20, Issue 1, Pages 86-89Publisher
SPRINGER
DOI: 10.1007/s10165-009-0232-7
Keywords
TNF inhibitors; Infliximab; Etanercept; Cutaneous vasculitis; Leukocytoclastic vasculitis
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We describe 3 rheumatoid arthritis (RA) patients with anti-tumor necrosis factor (TNF) therapy-induced cutaneous vasculitis. Two cases were induced by infliximab and the other, in whom cutaneous vasculitis was found early at the start of therapy, was induced by etanercept. Skin biopsy was obtained in 2 patients, with histology-proven leukocytoclastic vasculitis. One patient spontaneously improved after cessation of the TNF inhibitor. Two patients required oral corticosteroid, the efficacy of which was observed to be excellent and rapid.
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