Article
Biochemistry & Molecular Biology
Malte Lenders, David Scharnetzki, Ali Heidari, Daniele Di Iorio, Seraphine Valeska Wegner, Eva Brand
Summary: This study generated a patient-derived antibody mixture as a reference for quantification of ADA titers, showing that ADAs from patients with FD have comparable affinities to agalsidase-alpha, agalsidase-beta and Moss-AGAL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pediatrics
Xin Wang, Xiao-wei Liu, Ling Han, Meng-tao Li, Jiu-liang Zhao, Lin Sun, Jian-cheng Han, Xiao-feng Zeng, Xin-ping Tian, Ying Zhao, Yi-hua He
Summary: This study analyzed fetal cardiac manifestations due to maternal anti-Ro and anti-La antibodies in China, revealing three distinct groups: isolated-arrhythmia, isolated-EFE, and mixed groups. The isolated-arrhythmia group often presented with atrioventricular block, while severe EFE, moderate-severe mitral regurgitation, and dilated cardiomyopathy were more common in the mixed group.
FRONTIERS IN PEDIATRICS
(2022)
Article
Biotechnology & Applied Microbiology
Yuki Higashimoto, Kei Kozawa, Hiroki Miura, Yoshiki Kawamura, Masaru Ihira, Hiroyuki Hiramatsu, Ryota Suzuki, Kei Haga, Reiko Takai-Todaka, Akihito Sawada, Kazuhiko Katayama, Tetsushi Yoshikawa
Summary: S-IgG antibody titers increased significantly after BNT162b2 vaccination, and there was a strong correlation between S-IgG antibody titers and neutralizing antibody titers against three live SARS-CoV-2 variants. One dose of the vaccine provided better neutralization against the Alpha variant, but lower neutralization against the KUH003 and Delta variants. Two doses of the vaccine induced a strong immune response, and serum samples showed significantly lower neutralizing activity against the Delta variant.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Rheumatology
Edgar Jaeggi, Vathany Kulasingam, Jack Chen, Chun-Po Steve Fan, Carl Laskin, Robert M. M. Hamilton, Linda T. T. Hiraki, Earl D. D. Silverman, Lusia Sepiashvili
Summary: This study examined the association between anti-Ro antibody titers and fetal CNL. It found that CNL is associated with higher levels of anti-Ro antibodies than what is measured using standard methods. Expanding the measuring range of the assay can improve the specificity of identifying pregnancies at risk of CNL.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Maria L. Sembler-Moller, Daniel Belstrom, Henning Locht, Anne Marie L. Pedersen
Summary: The study found that the simultaneous presence of serum anti-SSA/Ro and upregulated salivary TRIM29 in patients with pSS has high diagnostic accuracy and represents a promising less invasive diagnostic tool. Further testing is needed to assess the clinical applicability of TRIM29 in independent cohorts using relevant analytical techniques.
Article
Immunology
Fangting Lu, Yanshi Wang, Xuhui Fang, Rentao Jin, Bo Xu, Qiannan Qiu, Li Wu
Summary: This study found that there are differences in menstrual blood cell composition between women with anti-SSA/SSB antibodies and normal controls, especially in terms of CD49a+ NK cells and CD8+T cells, which may unbalance the immune cell composition and inflammatory uterine microenvironment and contribute to adverse pregnancy outcomes.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Rheumatology
Hieronymus T. W. Smeele, Marco W. J. Schreurs, Nathalie Costedoat-Chalumeau, Jerome M. J. Cornette, Radboud J. E. M. Dolhain
Summary: This study found a low prevalence of anti-SSA and anti-SSB autoantibodies in RA patients wishing to conceive or pregnant. Especially for RF-negative patients, the current recommendation to test for anti-SSA and anti-SSB may need to be reconsidered.
Article
Immunology
Xuhui Fang, Fangting Lu, Yanshi Wang, Lan Guo, Yu Zhang, Shun Bai, Joanne Kwak-Kim, Li Wu
Summary: Women with anti-Ro/SSA and/or anti-La/SSB antibodies have poor outcomes in IVF and pregnancy, including lower fertilization rates, embryo development, and clinical pregnancy rates.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Obstetrics & Gynecology
Alexander M. Kaizer, Christopher Lindblade, Robert Clancy, Anne E. Tebo, Bailey Drewes, Mala Masson, Miao Chang, Nicola Fraser, Jill P. Buyon, Bettina F. Cuneo
Summary: This study aimed to define the thresholds for anti-Ro52 and anti-Ro60 antibodies in order to identify fetuses unlikely to develop atrioventricular block.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Neurosciences
Rajiv Radhakrishnan, Patrick D. Worhunsky, Ming-Qiang Zheng, Soheila Najafzadeh, Jean-Dominique Gallezot, Beata Planeta, Shannan Henry, Nabeel Nabulsi, Mohini Ranganathan, Patrick D. Skosnik, Brian Pittman, Deepak Cyril D'Souza, Richard E. Carson, Yiyun Huang, Marc N. Potenza, David Matuskey
Summary: The study examined the relationship between brain cannabinoid 1 receptors (CB1Rs) and age, gender, and body mass index (BMI) in healthy individuals. It found that CB1R availability declined with age and differed between genders and brain regions. The findings were different from previous studies and highlight the need for cross-validation studies using different PET ligands in the same cohort.
Article
Clinical Neurology
Shenghua Zong, Anita M. M. Vinke, Peng Du, Carolin Hoffmann, Marina Mane-Damas, Peter C. C. Molenaar, Jan G. M. C. Damoiseaux, Mario Losen, Rob P. W. Rouhl, Pilar Martinez-Martinez
Summary: The clinical significance of anti-GAD65 autoantibodies (GAD65-Abs) in patients with epilepsy and other neurological disorders is still unclear. High levels of GAD65-Abs are considered pathogenic, while low or moderate levels are seen as bystanders in diseases like diabetes mellitus type 1 (DM1). The value of cell-based assays (CBA) and immunohistochemistry (IHC) for detecting GAD65-Abs has not been clearly evaluated in this context.
FRONTIERS IN NEUROLOGY
(2023)
Article
Endocrinology & Metabolism
Mitsuru Doi, Ko Chiba, Narihiro Okazaki, Choko Kondo, Shuta Yamada, Kazuaki Yokota, Akihiko Yonekura, Masato Tomita, Makoto Osaki
Summary: The study found that age-related changes in bone microstructure in men involve decreases in trabecular and cortical volumetric bone density, decreased trabecular number, cavitation of the trabecular structure, and increased cortical porosity. Femoral aBMD was strongly correlated with bone microstructure in the tibia, while biochemical markers showed almost no relationships with bone microstructure.
Article
Medicine, General & Internal
Antonio Ji-Xu, Liam Carroll, Thomas Bentley, Rachael Jarrett
Summary: This article describes a case of acute leucocytoclastic vasculitis caused by G-CSF therapy in a patient with multiple myeloma, emphasizing the importance of a high index of suspicion for acute leucocytoclastic vasculitis in patients with haematological malignancies undergoing G-CSF therapy.
Article
Dermatology
Jamaji C. Nwanaji-Enwerem, Ugoji Nwanaji-Enwerem, Andrea A. Baccarelli, Ramone F. Williams, Elena Colicino
Summary: The study found that partial responders to anti-TNF therapy had higher SkinBloodAges compared to excellent responders, suggesting that SkinBloodAge may serve as a useful treatment response biomarker in moderate-to-severe psoriasis patients.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Parasitology
Ana Carolina Cavallieri, Luciane Holsback, Eloiza Teles Caldart, Luana Zaboski Pena, Pablo Menegon Castilho, Fernanda Pinheiro Filgueiras, Ellen de Souza Marquez, Mariza Fordellone Rosa Cruz, Kerlei Cristina Medici, Regina Mitsuka-Bregano, Italmar Teodorico Navarro
Summary: This study evaluated the occurrence of Leishmania infection in dogs from urban and rural areas in the North Pioneer Mesoregion of Parana state and analyzed the statistical agreement between the serological techniques used. The results showed that 14.2% of dogs were seropositive for Leishmania using ELISA, while 9.8% were seropositive using IFAT. No dogs tested positive for Leishmania DNA. This study highlights the presence of Leishmania parasites in dogs from both urban and rural areas, emphasizing the importance of proper prevention and information for the local population.
REVISTA BRASILEIRA DE PARASITOLOGIA VETERINARIA
(2023)
