Article
Pathology
Hanna Hametoja, Antti Makitie, Leif Back, Ilmo Leivo, Caj Haglund, Timo Sorsa, Jaana Hagstrom
Summary: In this study on adenoid cystic carcinoma (ACC), the expression of MMP-9 in pseudocysts and peritumoural inflammatory cells was found to be associated with better survival and fewer treatment failures. High tumoural MMP-7 and-25 were linked to better survival, while high tumoural MMP-15 was associated with poorer survival and high tumoural MMP-9 with advanced stage and regional recurrences. Tumour cells did not show MMP-8 immunopositivity. These results suggest potential roles for MMPs in ACC carcinogenesis and prognosis.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Oncology
Jinxu Wen, Xiaoru Qin, Jiayi Zhang, Xiaoyong Wu, Xuemin Yan, Kewen Lu, Pei Yang, Shuaichong Ji, Xiangdong Zhao, Yuexin Wang
Summary: This study investigated the relationship between MMP-9 expression and pathological indexes in PTC. Results showed that MMP-9 expression was significantly correlated with lymph node metastasis, tumor size, and TNM stage, but not with gender and age. MMP-9 may serve as a reliable prognostic biomarker for PTC patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Ilias P. Nikas, Cheol Lee, Min Ji Song, Bohyun Kim, Han Suk Ryu
Summary: This study identified potential biomarker discrepancies between paired HGSOC primary tissues and metastatic peritoneal fluid cytology samples, suggesting that cytology from effusions could be considered for biomarker testing when tissue from the primary cancer is also available.
Article
Oncology
Younghoon Kim, Nam-Yun Cho, Lingyan Jin, Hye Yeong Jin, Gyeong Hoon Kang
Summary: The expression of STING in tumor cells is associated with favorable outcomes in solid tumors.
FRONTIERS IN ONCOLOGY
(2023)
Article
Andrology
Ya-Wei Zhao, Wang Ma, Fengjun Jiang, Yi Xie, Lei Tang
Summary: This study investigated the expression profile and functional role of matrix metalloproteinase 14 (MMP14) in kidney renal clear cell carcinoma (KIRC). The results showed that MMP14 was significantly upregulated in KIRC tissues and was associated with poor prognosis. The study also revealed that high expression of MMP14 was positively correlated with signaling pathways and pathways in cancer related to KIRC.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2022)
Article
Oncology
Philipp Kohn, Alexandros Lalos, Alberto Posabella, Alexander Wilhelm, Athanasios Tampakis, Ercan Caner, Uwe Guth, Sylvia Stadlmann, Giulio C. Spagnoli, Salvatore Piscuoglio, Sabine Richarz, Tarik Delko, Raoul A. Droeser, Gad Singer
Summary: High expression of CXCL12 in immune cells is associated with better chemosensitivity, overall survival, and longer recurrence-free survival in patients with high-grade serous ovarian carcinoma. Additionally, combined high density of CXCL12 and CD66b immune cells is an independent favorable predictor of recurrence-free survival.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Preston Carey, Ethan Low, Elizabeth Harper, M. Sharon Stack
Summary: Proteases, particularly those of the matrix metalloproteinase family, play a crucial role in ovarian cancer progression and metastasis by enhancing migratory ability, ECM breakdown, and tumor support system development. Upregulation of certain proteases influences angiogenesis for tumor growth and development of metastatic implants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Public, Environmental & Occupational Health
Bao-Jie Feng, Tian-Hua Li, Yue-Hong Li, Jing-Xuan Feng, Jun Zhang, Jun-Ying Ma, Yan-Wei Wang, Su-Shuang Lu
Summary: This study provides an overview of the clinicopathological characteristics of ovarian neuroendocrine carcinoma (O-NEC), a rare and diverse neoplasm. The different histological types of O-NEC have their own unique biological features and prognosis.
Article
Oncology
Qihui Wu, Xiaoyun He, Jiaxin Liu, Chunlin Ou, Yimin Li, Xiaodan Fu
Summary: Understanding the role of extracellular matrix (ECM) in HGSOC can help identify immune activation and assist patients in receiving proper therapy.
CANCER CELL INTERNATIONAL
(2023)
Article
Chemistry, Analytical
Yuhong Duan, Lu Xu, Wenyu Song, Hui Gao, Lina Sun, Fangfang Chen, Fen Ma
Summary: In this study, an electrogenerated chemiluminescence (ECL) biosensor based on heterodimerization interaction between CD44 and PEX-14 was developed for highly sensitive quantification of CD44. The biosensor exhibited excellent sensitivity and a wide linear range, making it suitable for detecting CD44 expression in living cells.
MICROCHEMICAL JOURNAL
(2022)
Article
Medicine, General & Internal
Michele Paudice, Chiara Maria Biatta, Giulia Scaglione, Alessia Parodi, Serafina Mammoliti, Melita Moioli, Maria Grazia Centurioni, Fabio Barra, Simone Ferrero, Franco De Cian, Katia Mazzocco, Valerio Gaetano Vellone
Summary: Endometrial cancer is a growing disease with an increase in aggressive histotypes. This study investigated potential prognostic markers and found that Bcl-2 and PR may have prognostic significance in high-grade non-endometrioid carcinoma patients.
Article
Oncology
Chun Chen, Lei Hang, Yupeng Liu, Jin Xie, Jun Yang
Summary: Postcricoid carcinoma is a rare and aggressive type of hypopharyngeal cancer with poor prognosis, requiring investigation of surgical efficacy and multimodal strategies. This study analyzed surgical resection cases from 2008 to 2022, finding associations between prognosis and factors such as tumor differentiation, lymph node metastasis, and treatment methods. Surgeons should focus on high-risk features and individualized surgical procedures to improve outcomes in postcricoid carcinoma patients.
Article
Oncology
Shaochong Lin, Junpeng Du, Jun Hao, Xiaohua Luo, Han Wu, Huifang Zhang, Xinxin Zhao, Lida Xu, BaoJin Wang
Summary: The study revealed that in ovarian cancer, the mRNA levels of FAM83A/D/E/F/H were significantly elevated, where the upregulation of FAM83D/H was associated with poor prognosis and might affect the survival outcomes of patients with ovarian cancer. Additionally, FAM83D/H were found to be involved in ovarian cancer progression through the cell cycle signaling pathway, with significant co-expression relationships with cell cycle-related genes.
CANCER MANAGEMENT AND RESEARCH
(2021)
Review
Reproductive Biology
M. Caroline Vos, Anneke A. M. van der Wurff, Toin H. van Kuppevelt, Leon F. A. G. Massuger
Summary: This systematic review evaluated the role of MMP-14 in ovarian cancer, revealing its importance in various processes of ovarian cancer development. While MMP-14 expression in clinicopathological research is associated with characteristics of poor prognosis, it does not seem to be an independent predictor of prognosis.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Oncology
Kyoko Yamaguchi, Tomoyasu Yoshihiro, Hiroshi Ariyama, Mamoru Ito, Michitaka Nakano, Yuichiro Semba, Jumpei Nogami, Kenji Tsuchihashi, Takuji Yamauchi, Shohei Ueno, Taichi Isobe, Koji Shindo, Taiki Moriyama, Kenoki Ohuchida, Masafumi Nakamura, Yoshihiro Nagao, Tetsuo Ikeda, Makoto Hashizume, Hiroyuki Konomi, Takehiro Torisu, Takanari Kitazono, Tomohiro Kanayama, Hiroyuki Tomita, Yoshinao Oda, Hitoshi Kusaba, Takahiro Maeda, Koichi Akashi, Eishi Baba
Summary: Loss of E-cadherin expression is frequently observed in signet ring carcinoma (SRCC). This study found that E-cadherin-deficient SRCC gains cell motility through upregulation of MMPs, and showed that CXCL12-positive cancer-associated fibroblasts can maintain cancer-cell survival.
Article
Neurosciences
A. Trepanier, S. Turcotte, G. Foldes-Busque
Summary: Chronic pain is influenced by an individual's distress tolerance, especially tolerance to negative emotions. Pain catastrophizing partially mediates the relationship between distress tolerance and pain interference in everyday functioning. Tolerance to negative emotions is an important factor in chronic pain and may be a clinical target.
ENCEPHALE-REVUE DE PSYCHIATRIE CLINIQUE BIOLOGIQUE ET THERAPEUTIQUE
(2022)
Article
Health Care Sciences & Services
Stephanie Hamel, Isabelle Denis, Stephane Turcotte, Richard Fleet, Patrick Archambault, Clermont E. Dionne, Guillaume Foldes-Busque
Summary: This study found a prospective association between comorbid panic disorder or generalized anxiety disorder and increased chest pain severity and lowered health-related quality of life in patients with noncardiac chest pain. Panic disorder appears to be mainly associated with the physical component of quality of life, while generalized anxiety disorder has a greater association with the mental component. Awareness of these differences can help in the management of patients with noncardiac chest pain and these comorbidities.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2022)
Review
Medicine, General & Internal
Carlotta Lunghi, Michele Dugas, Jacinthe Leclerc, Elisabetta Poluzzi, Cathy Martineau, Valerie Carnovale, Theo Stefan, Patrick Blouin, Johanie Lepine, Laura Jalbert, Nataly R. Espinoza Suarez, Olha Svyntozelska, Marie-Pier Dery, Giraud Ekanmian, Daniele Maria Nogueira, Pelumi Samuel Akinola, Stephane Turcotte, Becky Skidmore, Annie LeBlanc
Summary: This study aims to estimate the prevalence of antidepressant use in the community by conducting a systematic review. The researchers will search for relevant studies, perform data synthesis and analysis, and disseminate the findings through various channels.
Article
Oncology
Charles Dariane, Sylvie Clairefond, Benjamin Peant, Laudine Communal, Zhe Thian, Veronique Ouellet, Dominique Trudel, Nazim Benzerdjeb, Feryel Azzi, Arnaud Mejean, Marc-Olivier Timsit, Manon Baures, Jacques-Emmanuel Guidotti, Vincent Goffin, Pierre I. Karakiewicz, Anne-Marie Mes-Masson, Fred Saad
Summary: Keratin-7 overexpression is associated with poor prognosis in several cancers, and its high expression in benign glands surrounding localized prostate tumors is correlated with shorter bone metastasis-free survival and increased risk of cancer-specific mortality. In prostate cancer patients, high Keratin-7 expression is significantly associated with hypertrophic basal cell phenotype.
Article
Neurosciences
Marie-France de Lafontaine, Stephane Turcotte, Isabelle Denis, Guillaume Foldes-Busque
Summary: This study aimed to explore the associations between distress tolerance model and anxiety, as well as anxiety sensitivity. The results showed that tolerance of negative emotion and uncertainty were associated with anxiety, and these associations were partially mediated by anxiety sensitivity.
ANXIETY STRESS AND COPING
(2023)
Article
Psychology, Clinical
Marie-Andree Tremblay, Isabelle Denis, Stephane Turcotte, Michel DeGrace, Phillip J. Tully, Guillaume Foldes-Busque
Summary: This study assessed the feasibility and acceptability of an adapted cognitive-behavioral therapy (CBT) for panic disorder in patients with comorbid coronary artery disease (CAD) and evaluated its efficacy in reducing panic disorder symptoms, psychological distress, and improving quality of life. The results showed that the intervention was feasible and acceptable in patients with comorbid CAD, and the effects on symptoms and quality of life were maintained at the 6-month follow-up.
JOURNAL OF CLINICAL PSYCHOLOGY IN MEDICAL SETTINGS
(2023)
Article
Environmental Sciences
Lydi-Anne Vezina-Im, Dominique Beaulieu, Stephane Turcotte, Joanie Roussel-Ouellet, Valerie Labbe, Danielle Bouchard
Summary: The study aimed to examine the association between recreational screen time and sleep quality among adolescents during the third wave of the COVID-19 pandemic in Canada. The findings showed that adolescent boys had higher recreational screen time and sleep quality scores compared to girls. Recreational screen time and frequency of concurrent screen use were negatively associated with sleep quality, while being a boy was positively associated with sleep quality.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Oncology
Karen Geoffroy, Patrick Laplante, Sylvie Clairefond, Feryel Azzi, Dominique Trudel, Jean-Baptiste Lattouf, John Stagg, Fred Saad, Anne-Marie Mes-Masson, Marie-Claude Bourgeois-Daigneault, Jean-Francois Cailhier
Summary: This study analyzed the distribution and prognostic impact of MFG-E8 protein expression in patients with prostate and renal cancers. It found that low levels of MFG-E8 were associated with worse clinical outcomes and that higher numbers of CD206(+) cells were found in the peripheral regions of renal clear cell carcinoma with lower MFG-E8 levels. The study suggests that MFG-E8 expression could potentially be used as a prognostic marker in prostate and renal cancers.
Article
Biochemical Research Methods
Fabien Picot, Roozbeh Shams, Frederick Dallaire, Guillaume Sheehy, Tran Trang, David Grajales, Mirela Birlea, Dominique Trudel, Cynthia Menard, Samuel Kadoury, Frederic Leblond
Summary: This study aimed to evaluate the accuracy of prostate cancer (PCa) detection using in situ Raman spectroscopy (RS) in a clinical trial and compare the biochemical differences between in vivo and ex vivo measurements. The results showed that PCa detection can be achieved using RS and machine learning models, but the detection performance was reduced in ex vivo measurements due to spatial registration inaccuracies.
JOURNAL OF BIOMEDICAL OPTICS
(2022)
Article
Biochemical Research Methods
David Orlando Grajales Lopera, Fabien Picot, Roozbeh Shams, Frederick Dallaire, Guillaume Sheehy, Stephanie Alley, Maroie Barkati, Guila Delouya, Jean-Francois Carrier, Mirela Birlea, Dominique Trudel, Frederic Leblond, Cynthia Menard, Samuel Kadoury
Summary: The combination of in-situ Raman spectroscopy and radiomics features from multiparametric magnetic resonance images (mpMRI) can improve the diagnosis and treatment efficacy of prostate cancer. By navigating a fiber-optics needle in the prostate for Raman spectroscopy, the tumor can be accurately targeted, leading to more precise biopsy and radiotherapy.
JOURNAL OF BIOMEDICAL OPTICS
(2022)
Article
Biochemical Research Methods
Sandryne David, Trang Tran, Frederick Dallaire, Guillaume Sheehy, Feryel Azzi, Dominique Trudel, Francine Tremblay, Atilla Omeroglu, Frederic Leblond, Sarkis Meterissian
Summary: As many as 60% of patients with early stage breast cancer undergo breast-conserving surgery, but a significant number of them need a second surgery due to incomplete resection of the lesions. This study developed a technique using Raman spectroscopy and machine learning to detect invasive breast cancer in surgically resected breast specimens. The results showed high sensitivity and specificity in detecting cancer cells on the margins of the specimens.
JOURNAL OF BIOMEDICAL OPTICS
(2023)
Article
Biochemical Research Methods
Guillaume Sheehy, Fabien Picot, Frederick Dallaire, Katherine Ember, Tien Nguyen, Kevin Petrecca, Dominique Trudel, Frederic Leblond
Summary: In this study, an open-sourced data processing software package was developed to isolate the inelastic scattering component from signals acquired using Raman spectroscopy devices. A novel morphological baseline removal technique (BubbleFill) was included in the package, which showed superior performance compared to standard algorithms. The package was validated on simulated and real-world in-human data, demonstrating improved data compatibility across different systems.
JOURNAL OF BIOMEDICAL OPTICS
(2023)
Article
Oncology
Mame-Kany Diop, Oscar Eduardo Molina, Mirela Birlea, Helene LaRue, Helene Hovington, Bernard Tetu, Louis Lacombe, Alain Bergeron, Yves Fradet, Dominique Trudel
Summary: The immune infiltrate of intraductal carcinoma of the prostate (IDC-P) is generally reduced compared to the surrounding tissues, especially regarding antigen-presenting cells. These findings could contribute to a better understanding of the immune response to lethal prostate cancer and the development of new therapies.
Article
Materials Science, Biomaterials
Nicholas Cunningham, Tommy Malaret, Pamela Thebault, Guillaume St-Jean, Feryel Azzi, Dominique Trudel, Rejean Lapointe, Sophie Lerouge
Summary: This study investigated the use of a gel for localized delivery of T cells in cancer immunotherapy. The gel demonstrated good biocompatibility and biodegradability without adverse effects. The encapsulated T cells showed efficacy against tumor cells both in vitro and in a mouse tumor model. The gel-encapsulated T cells limited tumor growth and showed potential for use in cancer immunotherapy, although further optimization is necessary.
BIOMATERIALS SCIENCE
(2023)
Article
Psychiatry
Guillaume Foldes-Busque, Marie-France de Lafontaine, Stephane Turcotte, Isabelle Denis
Summary: This study found that patients with noncardiac chest pain who visited the emergency department are at a higher risk of developing panic disorder in the two years following their visit. Anxiety sensitivity and stress related to life events were identified as predictors for the development of panic disorder.
JOURNAL OF THE ACADEMY OF CONSULTATION-LIAISON PSYCHIATRY
(2022)
Article
Pathology
Juliana Mota Siqueira, Yoshitsugu Mitani, Camilla Oliveira Hoff, Flavia Bonini, Luana Guimaraes de Sousa, Mario L. Marques-Piubelli, Anurag Purushothaman, Mutsumi Mitani, Hui Dai, Shiaw-Yih Lin, Michael T. Spiotto, Ehab Y. Hanna, Daniel J. McGrail, Adel K. El-Naggar, Renata Ferrarotto
Summary: B7-H4 expression pattern varies among different types of salivary gland carcinomas, and high B7-H4 expression is associated with poor prognosis in adenoid cystic carcinoma.
Article
Pathology
Basile Tessier-Cloutier, Felix K. F. Kommoss, David L. Kolin, Kristyna Nemejcova, Dupreez Smith, Jennifer Pors, Colin J. R. Stewart, W. Glenn Mccluggage, William D. Foulkes, Andreas von Deimling, Martin Kobel, Cheng-Han Lee
Summary: This study provides a detailed analysis of the clinical, pathological, immunohistochemical, and molecular features of DDOC/UDOC. The majority of patients presented with extraovarian disease and had rapid disease progression resulting in high mortality rate.
Review
Pathology
Sophia J. Wagner, Christian Matek, Sayedali Shetab Boushehri, Melanie Boxberg, Lorenz Lamm, Ario Sada, Dominik J. E. Winter, Carsten Marr, Tingying Peng
Summary: Computational pathology research driven by deep learning faces challenges in reproducibility and reusability. Codebase with good documentation and robustness and generalizability of models are crucial. The reuse of computational pathology algorithms is limited, and their application in clinical settings is even rarer. This study evaluates 160 peer-reviewed articles, providing criteria for data and code availability and statistical analysis of results.
Article
Pathology
Andres M. Acosta, Lynette M. Sholl, Fiona Maclean, Chia-Sui Kao, Thomas M. Ulbright
Summary: This study assessed the clinicopathologic and genomic features of 14 cases of testicular sex cord-stromal tumors. The results showed that CTNNB1 mutations are rare in these tumors, and most of them have genomic alterations similar to testicular sex cord-stromal tumors with pure or predominant spindle cell components.
Article
Pathology
Toru Odate, Kaishi Satomi, Takashi Kubo, Yuko Matsushita, Toshihide Ueno, Akira Kurose, Kohei Shomori, Tokiko Nakai, Reiko Watanabe, Keiko Segawa, Shusa Ohshika, Naritomo Miyake, Sayaka Kudo, Tatsunori Shimoi, Eisuke Kobayashi, Motokiyo Komiyama, Seiichi Yoshimoto, Fumihiko Nakatani, Akira Kawai, Yasushi Yatabe, Shinji Kohsaka, Koichi Ichimura, Hitoshi Ichikawa, Akihiko Yoshida
Summary: Inflammatory rhabdomyoblastic tumors (IRMTs) are newly recognized skeletal muscle tumors with uncertain malignant potential. This study investigated 13 IRMTs using clinicopathologic, genetic, and epigenetic methods. The results showed specific histologic features and genetic mutations in these tumors, and most of them exhibited benign behavior.
Article
Pathology
Dale L. Davis, Adam C. Lechner, David B. Chapel, Jonathan C. Slack, Chrystalle Katte Carreon, Bradley J. Quade, Carlos Parra-Herran
Summary: The Amsterdam Consensus Statement introduced the term maternal vascular malperfusion (MVM) to classify a group of findings related to impaired maternal-placental circulation. The study found that features such as low placental weight, accelerated villous maturation, decidual arteriopathy, and infarcts are associated with adverse obstetrical outcomes, while the role of other features like distal villous hypoplasia, excess multinucleated trophoblast, and retroplacental hemorrhage needs further research.
Review
Pathology
Alain C. Borczuk
Summary: COVID-19 is an acute respiratory illness that can progress to acute respiratory distress syndrome. While most patients recover completely, some may experience persistent respiratory dysfunction, known as long COVID. The pathogenesis involves immune and cellular disturbances.
Article
Pathology
Annikka Weissferdt, Cheuk H. Leung, Heather Lin, Boris Sepesi, William N. William, Stephen G. Swisher, Tina Cascone, J. Jack Lee, Abujiang Pataer
Summary: Neoadjuvant treatment of non-small cell lung cancer challenges traditional processing of pathology specimens, and accurate evaluation of residual tumor is crucial for assessing treatment efficacy.
