Review
Oncology
Andrew Xiao, Nahid Shahmarvand, Alexandra Nagy, Jyoti Kumar, Jessica Van Ziffle, Patrick Devine, Franklin Huang, Lhara Lezama, Peng Li, Robert S. S. Ohgami
Summary: ALK+ LBCL is an aggressive and rare subtype of B-cell lymphoma. A unique case of ALK+ LBCL with a rare TFG::ALK fusion is reported, highlighting the need for larger genetic profiling studies. Deletions of FOXO1, PRKCA, and the MYB locus were also detected. This case report contributes to understanding the pathogenesis and potential therapeutic targets of this aggressive disease.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Yuan Wang, Jing He, Manyu Xu, Qingfeng Xue, Cindy Zhu, Juan Liu, Yaping Zhang, Wenyu Shi
Summary: This review provides an overview of research progress on ALK+ ALCL, including the study of drug resistance mechanisms and the application and development of new therapies. Potential treatment strategies are proposed to guide the design of future clinical trials.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pathology
Jian Jeff Fu, Anjali Seth, Nadia Ali, Ashwin Chandar, Ashish Bains
Summary: ALK-positive large B-cell lymphoma (LBCL) is a rare and aggressive type of LBCL with poor prognosis. This case report highlights a unique expression of epithelial-associated markers and a novel PABPC1::ALK fusion gene in ALK-positive LBCL. It also emphasizes the importance of comprehensive immunophenotyping to avoid misdiagnosis and contributes to the understanding of this uncommon lymphoma.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Oncology
Yuxue Xia, Lu Zhang, Wenjuan He, Huaxiong Pan, Jun Fang, Guohui Cui
Summary: This study reported a case of ALK(+) LBCL in which the patient had progressive disease after treatment with crizotinib and chemotherapy, but achieved partial response and remained stable after treatment with alectinib combined with hyper-CVAD, followed by alectinib monotherapy.
CANCER BIOLOGY & THERAPY
(2023)
Editorial Material
Clinical Neurology
Wanakorn Rattanawong, Arnant Tekarnjnavanit, Chayoot Marukatat, Pasin Hemachudha, Thanakit Pongpitakmetha, Prakit Anukoolwittaya
Summary: This article reports a case of a 22-year-old man who presented with new-onset, gradually progressive diffuse headache. The patient exhibited limited bilateral lateral rectus movement and bilateral papilledema on fundoscopic examination. Brain MRI revealed multiple nodular-enhancing lesions along both sides of the falx cerebri, forming a branching network. After treatment, the patient achieved complete remission and resolution of headache.
Article
Oncology
Chuquan Shang, Bardes Hassan, Moinul Haque, Yuqi Song, Jing Li, Dongzhe Liu, Eva Lipke, Will Chen, Sylvie Giuriato, Raymond Lai
Summary: The study demonstrated that inhibiting autophagy in ALK + ALCL can increase drug sensitivity in stem-like cells, with differential Myc gene expression playing a critical role in this process. Stem-like cells have a greater impact on the efficacy of therapeutic drugs, indicating their crucial role in drug resistance.
Article
Oncology
Camille Daugrois, Chloe Bessiere, Sebastien Dejean, Veronique Anton-Leberre, Therese Commes, Stephane Pyronnet, Pierre Brousset, Estelle Espinos, Laurence Brugiere, Fabienne Meggetto, Laurence Lamant
Summary: The study identified genes associated with clinical outcomes in ALK-positive anaplastic large cell lymphoma by analyzing gene expression profiling of 48 samples, particularly highlighting the potential role of the FN1 gene. Furthermore, FN1, along with other genes, was found to predict both prognosis and therapeutic response in anaplastic lymphomas.
Article
Hematology
Elif Karaca Atabay, Carmen Mecca, Qi Wang, Chiara Ambrogio, Ines Mota, Nina Prokoph, Giulia Mura, Cinzia Martinengo, Enrico Patrucco, Giulia Leonardi, Jessica Hossa, Achille Pich, Luca Mologni, Carlo Gambacorti-Passerini, Laurence Brugieres, Birgit Geoerger, Suzanne D. Turner, Claudia Voena, Taek-Chin Cheong, Roberto Chiarle
Summary: This study identified PTPN1 and PTPN2 phosphatases as drivers of resistance to ALK TKIs in ALK(+) ALCL. These phosphatases regulate ALK phosphorylation and activity, and their loss leads to TKI resistance. Furthermore, SHP2 is a key mediator of oncogenic ALK signaling, and PTPN1 acts as a phosphatase for SHP2. Combination therapy with a SHP2 inhibitor can overcome TKI resistance in ALK(+) ALCL.
Editorial Material
Hematology
Fabian Frontzek, Georg Lenz
Summary: This study presents the first patient-derived xenograft (PDX) mouse models of anaplastic lymphoma kinase (ALK)-positive large B-cell lymphoma (LBCL), aiming to investigate new therapeutic approaches. The researchers found that the next-generation ALK inhibitors, alectinib and lorlatinib, showed promising activity in both preclinical in vivo PDX models and heavily pre-treated patients with relapsed/refractory ALK-LBCL.
Review
Oncology
Jorge J. Castillo, Brady E. Beltran, Luis Malpica, Mario L. Marques-Piubelli, Roberto N. Miranda
Summary: ALK+ large B-cell lymphoma is rare and aggressive, with male predominance and not associated with chronic viral infections. The prognosis is poor, but early disease stage is associated with better outcomes. Additional research is needed to better understand and treat this condition.
LEUKEMIA & LYMPHOMA
(2021)
Article
Multidisciplinary Sciences
Fabian Frontzek, Annette M. Staiger, Myroslav Zapukhlyak, Wendan Xu, Irina Bonzheim, Vanessa Borgmann, Philip Sander, Maria Joao Baptista, Jan-Niklas Heming, Philipp Berning, Ramona Wullenkord, Tabea Erdmann, Mathias Lutz, Pia Veratti, Sophia Ehrenfeld, Kirsty Wienand, Heike Horn, John R. Goodlad, Matthew R. Wilson, Ioannis Anagnostopoulos, Mario Lamping, Eva Gonzalez-Barca, Fina Climent, Antonio Salar, Josep Castellvi, Pau Abrisqueta, Javier Menarguez, Teresa Aldamiz, Julia Richter, Wolfram Klapper, Alexandar Tzankov, Stefan Dirnhofer, Andreas Rosenwald, Jose Luis Mate, Gustavo Tapia, Peter Lenz, Cornelius Miething, Wolfgang Hartmann, Bjoern Chapuy, Falko Fend, German Ott, Jose-Tomas Navarro, Michael Grau, Georg Lenz
Summary: Plasmablastic lymphoma (PBL) is an aggressive lymphoma subtype with poor prognosis and limited molecular knowledge. A study on primary samples using whole exome sequencing highlights IRF4 and JAK-STAT pathways as potential therapeutic targets for improving outcomes in PBL patients.
NATURE COMMUNICATIONS
(2021)
Review
Medicine, General & Internal
Jose Manuel Martin de Bustamante, Ana Mendoza, Samuel Lopez-Munoz, Eugenia Garcia-Fernandez, Pilar Gomez-Prieto, Victor Jimenez-Yuste
Summary: Recently, a new lymphoproliferative entity called breast implant-associated Epstein-Barr virus positive (EBV+) diffuse large B-cell lymphoma (EBV+ BIA-DLBCL) has been reported. The World Health Organization has categorized it as fibrin-associated large B-cell lymphomas (FA-LBCLs), thus it can be referred to as breast implant-associated fibrin-associated large B-cell lymphomas (BIA-FA-LBCLs). While the association between breast implants and lymphomas has been known for a long time, it has mostly been focused on breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). This article describes the first case of BIA-FA-LBCL at a particular center, provides a literature review on its clinical features, diagnosis, and treatment approach, as well as explores the challenges in differential diagnosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pathology
Yoon Ah Cho, Jiyeon Hyeon, Hyunwoo Lee, Junhun Cho, Seok-Jin Kim, Won Seog Kim, Young-Hyeh Ko
Summary: MYC-rearranged large B-cell lymphoma with BCL2 and/or BCL6 rearrangement, double-hit or triple-hit lymphoma, is associated with poor survival. In contrast, single-hit MYC rearrangement showed high-grade morphology but similar survival rates to MYC-negative lymphomas.
Article
Hematology
Joan Enric Ramis-Zaldivar, Blanca Gonzalez-Farre, Alina Nicolae, Svetlana Pack, Guillem Clot, Ferran Nadeu, Anja Mottok, Heike Horn, Joo Y. Song, Kai Fu, George Wright, Randy D. Gascoyne, Wing C. Chan, David W. Scott, Andrew L. Feldman, Alexandra Valera, Anna Enjuanes, Rita M. Braziel, Erlend B. Smeland, Louis M. Staudt, Andreas Rosenwald, Lisa M. Rimsza, German Ott, Elaine S. Jaffe, Itziar Salaverria, Elias Campo
Summary: Plasmablastic lymphoma (PBL) is an aggressive B-cell lymphoma characterized by high genetic complexity and a variety of mutations and copy-number alterations. EBV-negative PBL cases tend to have more TP53, CARD11 and MYC mutations, while EBV-positive PBL cases are more affected by the JAK-STAT pathway.
Article
Pathology
Jung-Woo Choi, Youngseok Lee, Hyunchul Kim, Hyun Yee Cho, Soo Kee Min, Young-Sik Kim
Summary: In solid tumors and malignant lymphomas, lactate transport is regulated by different monocarboxylate transporters. Malignant lymphomas with ALK(+) ALCL show a unique metabolic phenotype characterized by high coexpression of MCT1 and MCT4 in tumor cells. Immunostaining for MCT4, together with ALK, can be useful for the differential diagnosis of ALK(-) ALCL and peripheral T-cell lymphoma. Dual targeting of MCT1 and MCT4 may be an appropriate therapeutic approach for ALK(+) ALCL.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Editorial Material
Hematology
Saber Tadros, Elaine S. Jaffe
Article
Hematology
Elias Campo, Elaine S. Jaffe, James R. Cook, Leticia Quintanilla-Martinez, Steven H. Swerdlow, Kenneth C. Anderson, Pierre Brousset, Lorenzo Cerroni, Laurence de Leval, Stefan Dirnhofer, Ahmet Dogan, Andrew L. Feldman, Falko Fend, Jonathan W. Friedberg, Philippe Gaulard, Paolo Ghia, Steven M. Horwitz, Rebecca L. King, Gilles Salles, Jesus San-Miguel, John F. Seymour, Steven P. Treon, Julie M. Vose, Emanuele Zucca, Ranjana Advani, Stephen Ansell, Wing-Yan Au, Carlos Barrionuevo, Leif Bergsagel, Wing C. Chan, Jeffrey I. Cohen, Francesco d'Amore, Andrew Davies, Brunangelo Falini, Irene M. Ghobrial, John R. Goodlad, John G. Gribben, Eric D. Hsi, Brad S. Kahl, Won-Seog Kim, Shaji Kumar, Ann S. LaCasce, Camille Laurent, Georg Lenz, John P. Leonard, Michael P. Link, Armando Lopez-Guillermo, Maria Victoria Mateos, Elizabeth Macintyre, Ari M. Melnick, Franck Morschhauser, Shigeo Nakamura, Marina Narbaitz, Astrid Pavlovsky, Stefano A. Pileri, Miguel Piris, Barbara Pro, Vincent Rajkumar, Steven T. Rosen, Birgitta Sander, Laurie Sehn, Margaret A. Shipp, Sonali M. Smith, Louis M. Staudt, Catherine Thieblemont, Thomas Tousseyn, Wyndham H. Wilson, Tadashi Yoshino, Pier-Luigi Zinzani, Martin Dreyling, David W. Scott, Jane N. Winter, Andrew Zelenetz
Summary: Since 1994, the classification of lymphoid neoplasms has been continuously updated through international efforts, with recent progress driven by genomic studies. This proposal presents the International Consensus Classification of mature lymphoid, histiocytic, and dendritic cell tumors, which has refined diagnostic criteria and incorporated new insights from genomics.
Article
Hematology
Fernando Gallardo, Evelyn Andrades, Arnau Iglesias, Jessica Gonzalez, Laura Sole, Yolanda Guillen, Gonzalo Blanco, Luis Colomo, Eva Gimeno, David Conde, Eva Rodriguez, Isabel Bielsa-Marso, Mar Iglesias, Beatriz Bellosillo, Ramon M. Pujol, Jose R. Regueiro, Anna Bigas, Lluis Espinosa
Summary: The current therapeutic approaches for Sezary syndrome (SS) have limited efficacy in improving long-term survival and mainly aim to reduce tumor burden. This study compiles methods for patient-derived xenograft (PDX) generation and management, providing new perspectives on SS treatment.
Article
Pathology
Juan Jose Rodriguez-Sevilla, Marta Salido, Maria Rodriguez-Rivera, Blanca Sanchez-Gonzalez, Fernando Gallardo, Ramon Maria Pujol, Luis Colomo
Summary: Deregulation of JAK-STAT pathway is relevant in mycosis fungoides (MFs). We present a case of a 23-year-old woman with atypical MF carrying isolated PCM1::JAK2 fusion and eosinophilia, which was refractory to common treatments. Treatment with brentuximab vedotin decreased the proportion of large cells but did not improve the low-grade component and skin lesions. Abnormal activation of JAK-STAT pathway was demonstrated by immunohistochemical expression of p-STAT3 in most tumor cells. Previous cases of mature T-cell lymphomas with PCM1::JAK2 fusion shared similar clinicopathological features and low genetic complexity.
Letter
Hematology
Ramon Diez-Feijoo, Concepcion Fernandez-Rodriguez, Marta Lafuente, Nieves Garcia-Gisbert, Ana Ferrer, Luis Colomo, Marta Salido, Antonio Salar
Article
Dermatology
Roger Rovira-Lopez, Fernando Gallardo, Antonio Salar, Lluis Colomo, Ramon M. Pujol
Summary: An 84-year-old woman presented with a 3-month history of papular rash. Histopathological examination revealed atypical lymphoid deep and band-like dermal infiltrates with marked epidermotropism. The expression of B-cell markers and aberrant expression of CD5 were observed in neoplastic cells and circulating lymphocytes, respectively. Staging workup revealed spleen enlargement, bone marrow, and gastrointestinal tract involvement. The case highlights the autoinvolutive and recurrent epidermotropic B-cell atypical cutaneous infiltrates as a characteristic feature of secondary cutaneous involvement in splenic marginal B-cell lymphoma.
AMERICAN JOURNAL OF DERMATOPATHOLOGY
(2023)
Correction
Pathology
Birgitta Sander, Elias Campo, Eric D. Hsi
Review
Pathology
Birgitta Sander, Elias Campo, Eric D. Hsi
Summary: This manuscript reviews the clinicopathologic and biologic features of chronic lymphocytic leukaemia/small lymphocytic lymphoma, B-cell prolymphocytic leukaemia, and mantle cell lymphoma. Discussions focus on incorporating new knowledge into the next classification system.
Letter
Pathology
Neval Ozkaya, Ina Lee, Terrica S. Johnson, Elaine S. Jaffe
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Letter
Hematology
Ting Zhou, Constance M. Yuan, Kathryn Lurain, Maryalice Stetler-Stevenson, Armando C. Filie, Stefania Pittaluga, Elaine S. Jaffe, Ramya Ramaswami, Robert Yarchoan, Hao-Wei Wang
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Pathology
Elaine S. Jaffe
Summary: The modern taxonomy of disease provides a framework for precision medicine that integrates traditional pathologic criteria with clinical and genomic features. Follicular lymphoma (FL) and diffuse large B-cell lymphoma are the two most common subtypes of lymphoma worldwide. Recent studies have revealed significant diversity among follicle center-derived lesions, and diffuse large B-cell lymphoma is a family of aggressive B-cell neoplasms with varied pathogenesis and clinical features. High-throughput sequencing has identified diverse mutational profiles that can guide targeted therapy and improve patient outcomes in the future.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Editorial Material
Hematology
James D. Phelan, Elaine S. Jaffe
Summary: In this study, the authors used whole genome sequencing to investigate the basis of follicular lymphoma (FL) transformation. They identified two genetically distinct subgroups of FL, dFL and cFL, which showed a significant difference in time to transformation.
Editorial Material
Hematology
Yanna Ding, Elaine S. Jaffe
Article
Oncology
Sara Montesdeoca, Nieves Garcia-Gisbert, Xavier Calvo, Leonor Arenillas, David Roman, Concepcion Fernandez-Rodriguez, Rosa Navarro, Beatriz Costan, Maria del Carmen Vela, Laura Camacho, Eugenia Abella, Lluis Colomo, Marta Salido, Anna Puiggros, Lourdes Florensa, Blanca Espinet, Beatriz Bellosillo, Ana Ferrer del Alamo
Summary: This study found that Waldenstrom Macroglobulinemia (WM) is a lymphoplasmacytic lymphoma with bone marrow involvement and IgM monoclonal gammopathy. The study further demonstrated the importance of peripheral blood (PB) involvement in the evaluation of patients with IgM monoclonal gammopathy and supported the role of PB multiparametric flow cytometry (MFC) analysis in the classification of mature B cell neoplasms.
Article
Hematology
Joaquim Carreras, Yara Yukie Kikuti, Masashi Miyaoka, Shinichiro Hiraiwa, Sakura Tomita, Haruka Ikoma, Yusuke Kondo, Atsushi Ito, Shunsuke Nagase, Hisanobu Miura, Giovanna Roncador, Lluis Colomo, Rifat Hamoudi, Elias Campo, Naoya Nakamura
Summary: We report a rare variant of diffuse large B-cell lymphoma with spindle cell morphology in a 74-year-old male patient who presented with right supraclavicular (lymph) node enlargement. The lymphoma was characterized by a cell-of-origin subtype of germinal center B-cell-like (GCB), and mutational profiling confirmed mutations in multiple genes associated with aggressive B-cell lymphomas. The immune microenvironment showed infiltration of tumor-associated macrophages and expression of certain markers associated with poor prognosis. The patient achieved a complete response with R-CHOP therapy.
HEMATOLOGY REPORTS
(2023)
Article
Pathology
Juliana Mota Siqueira, Yoshitsugu Mitani, Camilla Oliveira Hoff, Flavia Bonini, Luana Guimaraes de Sousa, Mario L. Marques-Piubelli, Anurag Purushothaman, Mutsumi Mitani, Hui Dai, Shiaw-Yih Lin, Michael T. Spiotto, Ehab Y. Hanna, Daniel J. McGrail, Adel K. El-Naggar, Renata Ferrarotto
Summary: B7-H4 expression pattern varies among different types of salivary gland carcinomas, and high B7-H4 expression is associated with poor prognosis in adenoid cystic carcinoma.
Article
Pathology
Basile Tessier-Cloutier, Felix K. F. Kommoss, David L. Kolin, Kristyna Nemejcova, Dupreez Smith, Jennifer Pors, Colin J. R. Stewart, W. Glenn Mccluggage, William D. Foulkes, Andreas von Deimling, Martin Kobel, Cheng-Han Lee
Summary: This study provides a detailed analysis of the clinical, pathological, immunohistochemical, and molecular features of DDOC/UDOC. The majority of patients presented with extraovarian disease and had rapid disease progression resulting in high mortality rate.
Review
Pathology
Sophia J. Wagner, Christian Matek, Sayedali Shetab Boushehri, Melanie Boxberg, Lorenz Lamm, Ario Sada, Dominik J. E. Winter, Carsten Marr, Tingying Peng
Summary: Computational pathology research driven by deep learning faces challenges in reproducibility and reusability. Codebase with good documentation and robustness and generalizability of models are crucial. The reuse of computational pathology algorithms is limited, and their application in clinical settings is even rarer. This study evaluates 160 peer-reviewed articles, providing criteria for data and code availability and statistical analysis of results.
Article
Pathology
Andres M. Acosta, Lynette M. Sholl, Fiona Maclean, Chia-Sui Kao, Thomas M. Ulbright
Summary: This study assessed the clinicopathologic and genomic features of 14 cases of testicular sex cord-stromal tumors. The results showed that CTNNB1 mutations are rare in these tumors, and most of them have genomic alterations similar to testicular sex cord-stromal tumors with pure or predominant spindle cell components.
Article
Pathology
Toru Odate, Kaishi Satomi, Takashi Kubo, Yuko Matsushita, Toshihide Ueno, Akira Kurose, Kohei Shomori, Tokiko Nakai, Reiko Watanabe, Keiko Segawa, Shusa Ohshika, Naritomo Miyake, Sayaka Kudo, Tatsunori Shimoi, Eisuke Kobayashi, Motokiyo Komiyama, Seiichi Yoshimoto, Fumihiko Nakatani, Akira Kawai, Yasushi Yatabe, Shinji Kohsaka, Koichi Ichimura, Hitoshi Ichikawa, Akihiko Yoshida
Summary: Inflammatory rhabdomyoblastic tumors (IRMTs) are newly recognized skeletal muscle tumors with uncertain malignant potential. This study investigated 13 IRMTs using clinicopathologic, genetic, and epigenetic methods. The results showed specific histologic features and genetic mutations in these tumors, and most of them exhibited benign behavior.
Article
Pathology
Dale L. Davis, Adam C. Lechner, David B. Chapel, Jonathan C. Slack, Chrystalle Katte Carreon, Bradley J. Quade, Carlos Parra-Herran
Summary: The Amsterdam Consensus Statement introduced the term maternal vascular malperfusion (MVM) to classify a group of findings related to impaired maternal-placental circulation. The study found that features such as low placental weight, accelerated villous maturation, decidual arteriopathy, and infarcts are associated with adverse obstetrical outcomes, while the role of other features like distal villous hypoplasia, excess multinucleated trophoblast, and retroplacental hemorrhage needs further research.
Review
Pathology
Alain C. Borczuk
Summary: COVID-19 is an acute respiratory illness that can progress to acute respiratory distress syndrome. While most patients recover completely, some may experience persistent respiratory dysfunction, known as long COVID. The pathogenesis involves immune and cellular disturbances.
Article
Pathology
Annikka Weissferdt, Cheuk H. Leung, Heather Lin, Boris Sepesi, William N. William, Stephen G. Swisher, Tina Cascone, J. Jack Lee, Abujiang Pataer
Summary: Neoadjuvant treatment of non-small cell lung cancer challenges traditional processing of pathology specimens, and accurate evaluation of residual tumor is crucial for assessing treatment efficacy.
