Article
Multidisciplinary Sciences
Jacqueline Bijnens, Annick Van den Bruel, Vincent Vander Poorten, Ingeborg Goethals, Steven Van Schandevyl, Catherine Dick, Frank De Geeter
Summary: This study retrospectively evaluated the ability of preoperative imaging modalities to localize parathyroid adenomas and found that F-18-fluorocholine-PET/CT is highly accurate in this regard. It showed that F-18-fluorocholine-PET/CT can obviate the need for total exploration in patients with discordant or negative ultrasound and scintigraphic results.
SCIENTIFIC REPORTS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ashwin Singh Parihar, Joyce Mhlanga, Carrie Ronstrom, Lisa R. Schmidt, Robert S. Figenshau, Farrokh Dehdashti, Richard L. Wahl
Summary: The study aimed to evaluate the diagnostic accuracy of Tc-99m-sestamibi SPECT/CT for solid renal masses. The results showed that Tc-99m-sestamibi SPECT/CT had higher sensitivity and specificity in diagnosing nonconcerning lesions compared to contrast-enhanced CT, which can help differentiate malignant and benign renal tumors.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Surgery
Shani Goren, Nunzia Cinzia Paladino, Shachar Laks, Thomas Cuny, Josiane Vaillant-Lombard, Clement Mennetrey, Dan Assaf, Elif Hindie, Carole Guerin, Christelle Fargette, David Taieb, Frederic Sebag
Summary: F-18-FCH PET/CT, used as a second-line imaging technique, plays an accurate role in guiding minimally invasive parathyroidectomy. When combined with first-line imaging results, F-18-FCH PET/CT can better predict uniglandular diseases, leading to a higher success rate of minimally invasive surgery and maintaining exceptional cure rates.
WORLD JOURNAL OF SURGERY
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Matthew D. Kay, Lilah F. Morris-Wiseman, Justin Caskey, Blair A. Winegar, Phillip H. Kuo
Summary: A 74-year-old woman with primary hyperparathyroidism underwent surgical consultation, where cervical and thoracic spine MRI scans from the previous 10 years revealed a potential parathyroid adenoma in a slowly enlarging paraesophageal lesion. Tc-99m-sestamibi SPECT/CT confirmed the presence of a large parathyroid adenoma in the paraesophageal lesion after surgical resection.
CLINICAL NUCLEAR MEDICINE
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
John W. Kirkland, Jason M. Zhao, Nathan E. McWhorter, Kevin P. Banks
Summary: Oncocytomas in the parotid gland are rare benign neoplasms composed of mitochondrial-rich oncocytes. Tc-99m-sestamibi scintigraphy and SPECT/CT are effective in localizing these tumors, which typically exhibit focal intense uptake of radiotracer. The hyperattenuating nature of parotid gland oncocytomas can be confirmed through imaging modalities like SPECT/CT.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Vincent Boudousq, Nicolas Guignard, Olivier Gilly, Benjamin Chambert, Adel Mamou, Olivier Moranne, Mathilde Zemmour, Haitham Sharara, Benjamin Lallemant
Summary: This study compared the use of F-18-fluorocholine PET/CT, cervical ultrasonography (CU), and conventional scintigraphic imaging modalities (MIBI scintigraphy) for preoperative localization of hyperfunctional parathyroids in patients with primary hyperparathyroidism (PHPT). The results showed that F-18-fluorocholine PET/CT had higher accuracy and sensitivity compared to CU and MIBI scintigraphy, making it the preferred method for PHPT diagnosis.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Review
Otorhinolaryngology
Sang-Woo Lee, Sung Ryul Shim, Shin Young Jeong, Seong-Jang Kim
Summary: This study compared the performance of different preoperative imaging modalities for the localization of pHPT through a network meta-analysis. The results suggest that choline PET-CT showed the best performance in both patient-based and lesion-based analyses.
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ju-Ling Cheng, Chien-Chin Hsu, Pei-Wen Wang, Kuo-Chiang Sung, Nan-Tsing Chiu, Lan-Yi Chiu, Yung-Cheng Huang
Summary: The study compared the diagnostic performances and target-to-background ratios between anterior 180 degrees and 360 degrees SPECT/CT imaging for Tc-99m-sestamibi parathyroid imaging. Results showed that the anterior 180 degrees technique provides superior lesion contrast compared to the full-arc 360 degrees technique.
ANNALS OF NUCLEAR MEDICINE
(2021)
Editorial Material
Medicine, General & Internal
Jang Yoo, Miju Cheon
Summary: This case study describes a 16-year-old female patient with primary hyperparathyroidism, who initially had negative results on cervical ultrasonography and Tc-99m-sestamibi single photon emission computed tomography/computed tomography for parathyroid adenoma. However, subsequent C-11-methionine positron emission tomography/CT revealed positive focal uptake indicative of a parathyroid adenoma, which was later confirmed pathologically.
Editorial Material
Medicine, General & Internal
Pawel Cichocki, Zbigniew Adamczewski, Jacek Kusmierek, Anna Plachcinska
Summary: A 61-year-old man was referred for myocardial perfusion scintigraphy to exclude coronary artery disease. However, the initial scan showed significant stress-induced ischemia due to heart motion caused by difficulties in breathing from a slipped mask during the study. Repeat acquisition without motion artifacts revealed no features of ischemia.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yan Liu, Lulu Yang, Hui Xu, Yiyuan Yang, Yiqian Liang, Aimin Yang, Xiaojiang Tang, Shengkai Lei, Ioannis Christakis, Pornpeera Jitpratoom, Jianjun Xue
Summary: Tc-99m-MIBI SPECT/CT parathyroid imaging has good sensitivity and high specificity in accurately locating hyperparathyroidism. The accuracy of localization is positively correlated with lesion weight and parathyroid hormone levels. Lightweight lesions are the main source of false-negative results in Tc-99m-MIBI SPECT/CT parathyroid imaging.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Oncology
Michail E. E. Klontzas, Emmanouil Koltsakis, Georgios Kalarakis, Kiril Trpkov, Thomas Papathomas, Apostolos H. H. Karantanas, Antonios Tzortzakakis
Summary: This study combines Tc-99m Sestamibi SPECT/CT and radiomics analysis to characterize benign renal oncocytic neoplasms. The combined model achieves higher accuracy (95%) than the radiomics-only model (75%) and visual evaluation of Tc-99m Sestamibi SPECT/CT alone (90.8%). This approach promises improvement in diagnostic accuracy and reduction in unnecessary surgery for benign tumors.
Article
Endocrinology & Metabolism
Sung Hye Kong, Jung Hee Kim, Sang Wan Kim, Chan Soo Shin
Summary: The study found that using Tc-99m-MIBI single-photon emission computed tomography/computed tomography can provide clinical information about parathyroid adenomas in patients with primary hyperparathyroidism, and that the localization effect of positron emission tomography is better for tumors.
ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Endocrinology & Metabolism
Yuhua Wang, Ye Liu, Na Li, Wanchun Zhang
Summary: This study investigated the differences in biochemical markers and lesion visualization on Tc-99m-MIBI imaging between PHPT and SHPT. The findings showed that PHPT patients had higher positive results and T/NT ratio on Tc-99m-MIBI SPECT/CT imaging compared to SHPT patients. The volume of parathyroid lesions in SHPT was smaller than in PHPT.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Health Care Sciences & Services
Pawel Cichocki, Michal Blaszczyk, Kamila Cygulska, Krzysztof Filipczak, Zbigniew Adamczewski, Jacek Kusmierek, Piotr Lipiec, Jaroslaw Damian Kasprzak, Anna Plachcinska
Summary: The repeatability of assessed MBF and MFR values was good in the whole myocardium, LAD, and LCX vascular territories, but poor in the RCA territory. This may be attributed to poor automatic heart orientation during post-processing and a cardiac creep phenomenon. Better automatic heart orientation and introduction of automatic motion correction are likely to improve this repeatability.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Pathology
Juliana Mota Siqueira, Yoshitsugu Mitani, Camilla Oliveira Hoff, Flavia Bonini, Luana Guimaraes de Sousa, Mario L. Marques-Piubelli, Anurag Purushothaman, Mutsumi Mitani, Hui Dai, Shiaw-Yih Lin, Michael T. Spiotto, Ehab Y. Hanna, Daniel J. McGrail, Adel K. El-Naggar, Renata Ferrarotto
Summary: B7-H4 expression pattern varies among different types of salivary gland carcinomas, and high B7-H4 expression is associated with poor prognosis in adenoid cystic carcinoma.
Article
Pathology
Basile Tessier-Cloutier, Felix K. F. Kommoss, David L. Kolin, Kristyna Nemejcova, Dupreez Smith, Jennifer Pors, Colin J. R. Stewart, W. Glenn Mccluggage, William D. Foulkes, Andreas von Deimling, Martin Kobel, Cheng-Han Lee
Summary: This study provides a detailed analysis of the clinical, pathological, immunohistochemical, and molecular features of DDOC/UDOC. The majority of patients presented with extraovarian disease and had rapid disease progression resulting in high mortality rate.
Review
Pathology
Sophia J. Wagner, Christian Matek, Sayedali Shetab Boushehri, Melanie Boxberg, Lorenz Lamm, Ario Sada, Dominik J. E. Winter, Carsten Marr, Tingying Peng
Summary: Computational pathology research driven by deep learning faces challenges in reproducibility and reusability. Codebase with good documentation and robustness and generalizability of models are crucial. The reuse of computational pathology algorithms is limited, and their application in clinical settings is even rarer. This study evaluates 160 peer-reviewed articles, providing criteria for data and code availability and statistical analysis of results.
Article
Pathology
Andres M. Acosta, Lynette M. Sholl, Fiona Maclean, Chia-Sui Kao, Thomas M. Ulbright
Summary: This study assessed the clinicopathologic and genomic features of 14 cases of testicular sex cord-stromal tumors. The results showed that CTNNB1 mutations are rare in these tumors, and most of them have genomic alterations similar to testicular sex cord-stromal tumors with pure or predominant spindle cell components.
Article
Pathology
Toru Odate, Kaishi Satomi, Takashi Kubo, Yuko Matsushita, Toshihide Ueno, Akira Kurose, Kohei Shomori, Tokiko Nakai, Reiko Watanabe, Keiko Segawa, Shusa Ohshika, Naritomo Miyake, Sayaka Kudo, Tatsunori Shimoi, Eisuke Kobayashi, Motokiyo Komiyama, Seiichi Yoshimoto, Fumihiko Nakatani, Akira Kawai, Yasushi Yatabe, Shinji Kohsaka, Koichi Ichimura, Hitoshi Ichikawa, Akihiko Yoshida
Summary: Inflammatory rhabdomyoblastic tumors (IRMTs) are newly recognized skeletal muscle tumors with uncertain malignant potential. This study investigated 13 IRMTs using clinicopathologic, genetic, and epigenetic methods. The results showed specific histologic features and genetic mutations in these tumors, and most of them exhibited benign behavior.
Article
Pathology
Dale L. Davis, Adam C. Lechner, David B. Chapel, Jonathan C. Slack, Chrystalle Katte Carreon, Bradley J. Quade, Carlos Parra-Herran
Summary: The Amsterdam Consensus Statement introduced the term maternal vascular malperfusion (MVM) to classify a group of findings related to impaired maternal-placental circulation. The study found that features such as low placental weight, accelerated villous maturation, decidual arteriopathy, and infarcts are associated with adverse obstetrical outcomes, while the role of other features like distal villous hypoplasia, excess multinucleated trophoblast, and retroplacental hemorrhage needs further research.
Review
Pathology
Alain C. Borczuk
Summary: COVID-19 is an acute respiratory illness that can progress to acute respiratory distress syndrome. While most patients recover completely, some may experience persistent respiratory dysfunction, known as long COVID. The pathogenesis involves immune and cellular disturbances.
Article
Pathology
Annikka Weissferdt, Cheuk H. Leung, Heather Lin, Boris Sepesi, William N. William, Stephen G. Swisher, Tina Cascone, J. Jack Lee, Abujiang Pataer
Summary: Neoadjuvant treatment of non-small cell lung cancer challenges traditional processing of pathology specimens, and accurate evaluation of residual tumor is crucial for assessing treatment efficacy.
