Article
Veterinary Sciences
Mara S. Varvil, Taylor Bailey, Deepika Dhawan, Deborah W. Knapp, Jose A. Ramos-Vara, Andrea P. dos Santos
Summary: This study aimed to investigate the differential expression of miRNAs in bladder tissue samples of normal canine urothelium and canine invasive UC (iUC). The results showed that 28 miRNAs were differentially expressed in iUC compared to normal urothelial tissue, with four miRNAs significantly downregulated in iUC. These miRNAs are associated with gene silencing, miRNAs in cancer, and miRNAs involved in DNA damage responses.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Oncology
Richard Colling, Hayleigh Colling, Lisa Browning, Clare Verrill
Summary: The study found that there is similar or even improved agreement on grading non-invasive urothelial carcinoma between glass slide and digital screen assessment, suggesting at least non-inferiority of digital pathology in grading these tumors.
Review
Oncology
Lukasz Bialek, Konrad Bilski, Jakub Dobruch, Wojciech Krajewski, Tomasz Szydelko, Piotr Kryst, Slawomir Poletajew
Summary: This study aimed to evaluate the effectiveness of non-invasive tests in the diagnosis of upper urinary tract urothelial carcinoma (UTUC). Among the 10,084 screened publications, 25 were included in the analysis. Most of the studies had small sample sizes and heterogeneous control groups. Voided urinary cytology was the most commonly used test, with low sensitivity and good specificity. Fluorescence in situ hybridization in diagnostic cytology showed higher sensitivity and similarly good specificity. Other urine or blood tests had limited research and varied results. Currently, there is a lack of high-quality data confirming the effectiveness of non-invasive tests in the diagnosis of UTUC.
Article
Medicine, General & Internal
Rui Yang, Jun-Xing Chen, Shu-Hang Luo, Ting-Ting Chen, Ling-Wu Chen, Bin Huang
Summary: This article reports a case of a 60-year-old male with invasive bladder cancer with squamous and glandular differentiation. The patient successfully preserved the bladder through a combination of chemotherapy and immunotherapy, and has been tumor-free for more than two years.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Oncology
Fidele Y. Musangile, Ibu Matsuzaki, Mitsuaki Okodo, Ayaka Shirasaki, Yurina Mikasa, Ryuta Iwamoto, Yuichi Takahashi, Fumiyoshi Kojima, Shin-ichi Murata
Summary: HPV infection rates in UC are low but significantly associated with squamous differentiation and poor prognosis. RNAscope is an ideal method for HPV detection in UC compared to other standard approaches.
Article
Oncology
Thomas van Doeveren, Jose A. Nakauma-Gonzalez, Andrew S. Mason, Geert J. L. H. van Leenders, Tahlita C. M. Zuiverloon, Ellen C. Zwarthoff, Isabelle C. Meijssen, Angelique C. van der Made, Antoine G. van Der Heijden, Kees Hendricksen, Bas W. G. van Rhijn, Charlotte S. Voskuilen, Job van Riet, Winand N. M. Dinjens, Hendrikus J. Dubbink, Harmen J. G. van de Werken, Joost L. Boormans
Summary: By sequencing genes in 15 UTUC patients treated by RNU, it was found that the majority of patients had a clonal relationship between UTUC and subsequent UCB, supporting the idea that UCBs following UTUC surgery are primarily clonally derived recurrences.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Nishita Tripathi, Yeonjung Jo, Abhishek Tripathi, Nicolas Sayegh, Haoran Li, Roberto Nussenzveig, Benjamin Haaland, Vinay M. Thomas, Sumati Gupta, Benjamin L. Maughan, Umang Swami, Sumanta K. Pal, Petros Grivas, Neeraj Agarwal, Deepika Sirohi
Summary: This study compared the mutational profile of tumors with urothelial carcinoma with squamous differentiation (UCS) and urothelial carcinoma (UC) histology. The findings suggest significant enrichment of KMT2D mutations in UCS and the potential role of chromatin remodeling genes as drivers and therapeutic targets.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Oncology
Gorka Larrinaga, Julio Calvete-Candenas, Jon Danel Solano-Iturri, Ana M. Martin, Angel Pueyo, Caroline E. Nunes-Xavier, Rafael Pulido, Juan F. Dorado, Jose I. Lopez, Javier C. Angulo
Summary: This study provides a novel description of the (Pro)renin receptor (PRR) protein and its prognostic role in invasive urothelial cancer of the bladder. It demonstrates that PRR expression is an independent prognostic marker and may be a potential target in urothelial carcinoma. The study suggests that PRR activates pathogenic pathways contributing to cell proliferation, immunosuppressive microenvironments, and aggressive neoplastic phenotypes.
Article
Multidisciplinary Sciences
Shingo Maeda, Kosei Sakai, Kenjiro Kaji, Aki Iio, Maho Nakazawa, Tomoki Motegi, Tomohiro Yonezawa, Yasuyuki Momoi
Summary: This study describes the therapeutic efficacy of lapatinib as a first-line treatment for muscle-invasive urothelial carcinoma. The results show that dogs treated with lapatinib/piroxicam had a greater reduction in the size of the primary tumor and improved survival compared to those treated with piroxicam alone. Exploratory analyses also showed that HER2 overexpression was associated with response and survival in dogs treated with lapatinib.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Aaron A. Mehus, Madison Jones, Mason Trahan, Kaija Kinnunen, Kaitlyn Berwald, Becker Lindner, Sarmad Al-Marsoummi, Xu Dong Zhou, Scott H. Garrett, Donald A. Sens, Mary Ann Sens, Seema Somji
Summary: Urothelial cancer (UC), specifically muscle invasive (MIUC) with squamous differentiation, commonly develops cisplatin (CIS) resistance. The expression of SOX2 is associated with reduced survival and CIS resistance in UC. In this study, the researchers used quantitative proteomics to identify SOX2 overexpression in arsenite-transformed UROtsa cells. Inhibition of SOX2 with the neddylation inhibitor Pevonedistat (PVD) reduced stemness and increased CIS sensitivity in the transformed cells. Combined treatment of PVD with CIS further promoted terminal differentiation and cell death. These findings suggest the potential use of PVD with CIS as a differentiation therapy for CIS-resistant MIUC tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Michele J. Hoffmann, Wolfgang A. Schulz
Summary: Urinary bladder cancer is among the top ten major cancers worldwide, with higher incidences in males, smokers, and highly industrialized countries. Gene mutations play a crucial role in the development of bladder cancer, particularly in a group of proteins regulating chromatin state and gene expression that are discovered to be frequently affected.
Article
Biochemistry & Molecular Biology
Ivonne A. Montes-Mojarro, Saki Hassas, Sina Staehle, Philip Sander, Niklas Harland, Lina Maria Serna-Higuita, Irina Bonzheim, Hans Boesmueller, Arnulf Stenzl, Falko Fend
Summary: This study aims to develop a multiparametric classification to distinguish low-grade and high-grade urothelial tumors by analyzing immunohistochemical stains and pathogenic mutations. Analysis of clinical and histological data revealed that PUN-LMP and LG-PUC belong to one cluster, while HG-PUC belongs to another cluster, providing guidance for clinical management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Urology & Nephrology
Keiichiro Mori, Takafumi Yanagisawa, Satoshi Katayama, Ekaterina Laukhtina, Benjamin Pradere, Hadi Mostafaei, Fahad Quhal, Pawel Rajwa, Marco Moschini, Francesco Soria, David D'andrea, Mohammad Abufaraj, Simone Albisinni, Wojciech Krajewski, Wataru Fukuokaya, Jun Miki, Takahiro Kimura, Shin Egawa, Jeremy Y. C. Teoh, Shahrokh F. Shariat
Summary: Sex is associated with worse survival outcomes in patients with muscle-invasive bladder urothelial carcinoma (MIBC) but not in those with non-muscle-invasive bladder urothelial carcinoma (NMIBC).
WORLD JOURNAL OF UROLOGY
(2023)
Article
Oncology
Zaishang Li, Xueying Li, Yonghong Li, Ying Liu, Peng Du, Zenqing Liu, Kefeng Xiao
Summary: A novel nomogram has been established for predicting CSS after RNU for invasive UTUC, showing superior accuracy and discrimination compared to the current AJCC-TNM staging system, with excellent validation results confirming its capabilities in discrimination and calibration.
Article
Medicine, General & Internal
D. F. Bajorin, J. A. Witjes, J. E. Gschwend, M. Schenker, B. P. Valderrama, Y. Tomita, A. Bamias, T. Lebret, S. F. Shariat, S. H. Park, D. Ye, M. Agerbaek, D. Enting, R. McDermott, P. Gajate, A. Peer, M. Milowsky, A. Nosov, J. N. Antonio Jr, K. Tupikowski, L. Toms, B. S. Fischer, A. Qureshi, S. Collette, K. Unsal-Kacmaz, E. Broughton, D. Zardavas, H. B. Koon, M. D. Galsky
Summary: In a trial involving patients with high-risk muscle-invasive urothelial carcinoma who had undergone radical surgery, adjuvant nivolumab showed longer disease-free survival compared to placebo, especially among patients with a PD-L1 expression level of 1% or more, despite an increase in treatment-related adverse events.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Surgery
Kevin N. Harrell, Mohammad R. Jajja, Lauren M. Postlewait, Bahar Memis, Shishir K. Maithel, Juan M. Sarmiento, N. Volkan Adsay, David A. Kooby
JOURNAL OF SURGICAL RESEARCH
(2020)
Review
Medical Laboratory Technology
Orhun Cig Taskin, Volkan Adsay
SEMINARS IN DIAGNOSTIC PATHOLOGY
(2019)
Article
Pathology
Orhun Cig Taskin, Gizem Akkas, Bahar Memis, Ipek Erbarut Seven, Olca Basturk, Kee-Taek Jang, Juan C. Roa, Juan Carlos Araya, Enrique Bellolio, Hector Losada, Juan Sarmiento, Serdar Balci, Burcin Pehlivanoglu, Michelle D. Reid, Jill Koshiol, Volkan Adsay
Article
Pathology
Olca Basturk, Britta Weigelt, Volkan Adsay, Jamal K. Benhamida, Gokce Askan, Lu Wang, Maria E. Arcila, Giuseppe Zamboni, Noriyoshi Fukushima, Rodrigo Gularte-Merida, Arnaud Da Cruz Paula, Pier Selenica, Rahul Kumar, Fresia Pareja, Christopher A. Maher, John Scholes, Yoshinao Oda, Donatella Santini, Leona A. Doyle, Iver Petersen, Uta Flucke, Christian Koelsche, Samuel J. Reynolds, Aslihan Yavas, Andreas von Deimling, Jorge S. Reis-Filho, David S. Klimstra
Article
Pathology
Deniz Tuncel, Olca Basturk, Kyle T. Bradley, Grace E. Kim, Yue Xue, Michelle D. Reid, Serdar Balci, Ipek Erbarut, Volkan Adsay
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
(2020)
Article
Oncology
Adalberto Miranda-Filho, Marion Pineros, Catterina Ferreccio, Volkan Adsay, Isabelle Soerjomataram, Freddie Bray, Jill Koshiol
INTERNATIONAL JOURNAL OF CANCER
(2020)
Review
Cell Biology
Juan C. Roa, Olca Basturk, Volkan Adsay
Summary: Pathological evaluation of gallbladder neoplasms poses challenges, especially with clinically and grossly inapparent lesions. Close attention is required for variations in epithelial alterations, including goblet cell metaplasia and surface cell changes. Complete sampling is crucial for diagnosing high-grade dysplasia and early gallbladder carcinoma, which may exhibit differing levels of invasiveness. Recent characterization has shown certain invasive carcinoma types in the gallbladder to be more advanced and aggressive.
Review
Cell Biology
Gaetano Paolino, Irene Esposito, Seung-Mo Hong, Olca Basturk, Paola Mattiolo, Takuma Kaneko, Nicola Veronese, Aldo Scarpa, Volkan Adsay, Claudio Luchini
Summary: Intraductal tubulopapillary neoplasm (ITPN) of the pancreas is a distinct pancreatic tumor entity with specific clinicopathological and molecular characteristics. This study provides a comprehensive analysis of ITPN and compares its features with those of pancreatic ductal adenocarcinoma (PDAC) and intraductal papillary mucinous neoplasm (IPMN). The findings contribute to the understanding of ITPN and have clinical implications for its diagnosis and treatment.
Review
Gastroenterology & Hepatology
Laura D. Wood, N. Volkan Adsay, Olca Basturk, Lodewijk A. A. Brosens, Noriyoshi Fukushima, Seung-Mo Hong, Sung-Joo Kim, Jae W. Lee, Claudio Luchini, Michael Noe, Martha B. Pitman, Aldo Scarpa, Aatur D. Singhi, Mariko Tanaka, Toru Furukawa
Summary: This review presents updated perspectives on key issues in the examination of pathological specimens in patients with intraductal papillary mucinous neoplasms (IPMN), providing a foundation for data-driven approaches.
Article
Surgery
Serkan Zenger, Bulent Gurbuz, Ugur Can, Ergin Erginoz, Ibrahim Halil Ozata, Serpil Postgil Yilmaz, Orhun Cig Taskin, Onder Peker, Volkan Adsay, Emre Balik, Dursun Bugra
Summary: The aim of this study is to evaluate the clinicopathologic associations of tumor budding (Bd) and other potential prognosticators in T3/4aN0 colon cancer patients and investigate their impact on the outcome. The results showed that high level of tumor budding negatively affects long-term oncological outcomes, and adjuvant chemotherapy should be considered for patients with Bd3 and lymphovascular invasion.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Emre Altinmakas, Hakan Dogan, Orhun Cig Taskin, Emre Ozoran, Dursun Bugra, Volkan Adsay, Emre Balik, Bengi Gurses
ABDOMINAL RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Emre Altinmakas, Hakan Dogan, Orhun Cig Taskin, Emre Ozoran, Dursun Bugra, Volkan Adsay, Emre Balik, Bengi Gurses
Summary: This study demonstrates that the size, number, and involvement of large veins in MR-detected extramural venous invasion (MREMVI) have an impact on the response to neoadjuvant therapy in rectal adenocarcinoma. These parameters should be considered in the MRI evaluation and prognostication of treatment response.
ABDOMINAL RADIOLOGY
(2022)
Article
Oncology
Yazeed Alwelaie, Kimberly S. Point du Jour, Sonal Pandya, Abigail L. Goodman, Barbara A. Centeno, Volkan Adsay, Michelle D. Reid
Summary: In pancreatic FNAs, the use of CytoLyt as a fixative is associated with tissue/tumor autolysis in the majority of cases, compared to formalin fixation. This may influence morphologic evaluation and potentially immunocytochemical staining. Cytopathologists and cytotechnologists should be aware of this issue and avoid using CytoLyt as a fixative for pancreatic FNAs.
CANCER CYTOPATHOLOGY
(2021)
Meeting Abstract
Medicine, Research & Experimental
Burcin Pehlivanoglu, Takashi Muraki, Michelle Reid, Bahar Memis, Yue Xue, Serdar Balci, Ipek Erbarut Seven, Juan Sarmiento, David Kooby, Shishir Maithel, Susan Tsai, Kathleen Christians, Douglas Evans, N. Volkan Adsay
LABORATORY INVESTIGATION
(2019)
Meeting Abstract
Pathology
Burcin Pehlivanoglu, Takashi Muraki, Michelle Reid, Bahar Memis, Yue Xue, Serdar Balci, Ipek Erbarut Seven, Juan Sarmiento, David Kooby, Shishir Maithel, Susan Tsai, Kathleen Christians, Douglas Evans, N. Volkan Adsay
Article
Pathology
Juliana Mota Siqueira, Yoshitsugu Mitani, Camilla Oliveira Hoff, Flavia Bonini, Luana Guimaraes de Sousa, Mario L. Marques-Piubelli, Anurag Purushothaman, Mutsumi Mitani, Hui Dai, Shiaw-Yih Lin, Michael T. Spiotto, Ehab Y. Hanna, Daniel J. McGrail, Adel K. El-Naggar, Renata Ferrarotto
Summary: B7-H4 expression pattern varies among different types of salivary gland carcinomas, and high B7-H4 expression is associated with poor prognosis in adenoid cystic carcinoma.
Article
Pathology
Basile Tessier-Cloutier, Felix K. F. Kommoss, David L. Kolin, Kristyna Nemejcova, Dupreez Smith, Jennifer Pors, Colin J. R. Stewart, W. Glenn Mccluggage, William D. Foulkes, Andreas von Deimling, Martin Kobel, Cheng-Han Lee
Summary: This study provides a detailed analysis of the clinical, pathological, immunohistochemical, and molecular features of DDOC/UDOC. The majority of patients presented with extraovarian disease and had rapid disease progression resulting in high mortality rate.
Review
Pathology
Sophia J. Wagner, Christian Matek, Sayedali Shetab Boushehri, Melanie Boxberg, Lorenz Lamm, Ario Sada, Dominik J. E. Winter, Carsten Marr, Tingying Peng
Summary: Computational pathology research driven by deep learning faces challenges in reproducibility and reusability. Codebase with good documentation and robustness and generalizability of models are crucial. The reuse of computational pathology algorithms is limited, and their application in clinical settings is even rarer. This study evaluates 160 peer-reviewed articles, providing criteria for data and code availability and statistical analysis of results.
Article
Pathology
Andres M. Acosta, Lynette M. Sholl, Fiona Maclean, Chia-Sui Kao, Thomas M. Ulbright
Summary: This study assessed the clinicopathologic and genomic features of 14 cases of testicular sex cord-stromal tumors. The results showed that CTNNB1 mutations are rare in these tumors, and most of them have genomic alterations similar to testicular sex cord-stromal tumors with pure or predominant spindle cell components.
Article
Pathology
Toru Odate, Kaishi Satomi, Takashi Kubo, Yuko Matsushita, Toshihide Ueno, Akira Kurose, Kohei Shomori, Tokiko Nakai, Reiko Watanabe, Keiko Segawa, Shusa Ohshika, Naritomo Miyake, Sayaka Kudo, Tatsunori Shimoi, Eisuke Kobayashi, Motokiyo Komiyama, Seiichi Yoshimoto, Fumihiko Nakatani, Akira Kawai, Yasushi Yatabe, Shinji Kohsaka, Koichi Ichimura, Hitoshi Ichikawa, Akihiko Yoshida
Summary: Inflammatory rhabdomyoblastic tumors (IRMTs) are newly recognized skeletal muscle tumors with uncertain malignant potential. This study investigated 13 IRMTs using clinicopathologic, genetic, and epigenetic methods. The results showed specific histologic features and genetic mutations in these tumors, and most of them exhibited benign behavior.
Article
Pathology
Dale L. Davis, Adam C. Lechner, David B. Chapel, Jonathan C. Slack, Chrystalle Katte Carreon, Bradley J. Quade, Carlos Parra-Herran
Summary: The Amsterdam Consensus Statement introduced the term maternal vascular malperfusion (MVM) to classify a group of findings related to impaired maternal-placental circulation. The study found that features such as low placental weight, accelerated villous maturation, decidual arteriopathy, and infarcts are associated with adverse obstetrical outcomes, while the role of other features like distal villous hypoplasia, excess multinucleated trophoblast, and retroplacental hemorrhage needs further research.
Review
Pathology
Alain C. Borczuk
Summary: COVID-19 is an acute respiratory illness that can progress to acute respiratory distress syndrome. While most patients recover completely, some may experience persistent respiratory dysfunction, known as long COVID. The pathogenesis involves immune and cellular disturbances.
Article
Pathology
Annikka Weissferdt, Cheuk H. Leung, Heather Lin, Boris Sepesi, William N. William, Stephen G. Swisher, Tina Cascone, J. Jack Lee, Abujiang Pataer
Summary: Neoadjuvant treatment of non-small cell lung cancer challenges traditional processing of pathology specimens, and accurate evaluation of residual tumor is crucial for assessing treatment efficacy.