Article
Chemistry, Multidisciplinary
Chendong Liu, Lian Li, Jiayan Lyu, Yucheng Xiang, Liqiang Chen, Zhou Zhou, Yuan Huang
Summary: A split bullets loaded nanoplatform is developed to enhance the function of dendritic cells (DCs) in adaptive antitumor immunity by bidirectionally damaging the mitochondria and endoplasmic reticulum of tumor cells.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Biochemistry & Molecular Biology
Mary Adebayo, Seema Singh, Ajay Pratap Singh, Santanu Dasgupta
Summary: Mitochondria are dynamic organelles inherited maternally, fulfilling cellular energy demand and playing roles in cell signaling, metabolism, and apoptosis. Maintenance of mitochondrial integrity and homeostasis through fusion and fission is crucial, and imbalance can lead to various diseases.
Review
Biochemistry & Molecular Biology
Roberta A. Gottlieb, Honit Piplani, Jon Sin, Savannah Sawaged, Syed M. Hamid, David J. Taylor, Juliana de Freitas Germano
Summary: Mitochondrial quality control relies on various mechanisms such as selective elimination of damaged mitochondria, mitochondrial biogenesis, fusion, and fission, which are crucial for maintaining heart health.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Jirapong Vongsfak, Wasana Pratchayasakul, Nattayaporn Apaijai, Tanat Vaniyapong, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: Cerebral ischemia and reperfusion injury can lead to poor oxygen supply, brain infarction, and an imbalance in mitochondrial dynamics, which plays a crucial role in cell survival and infarct area size regulation. Understanding and regulating mitochondrial dynamics may help prevent or treat cerebral injury.
Article
Biochemistry & Molecular Biology
Xundong Wei, Jianhua Zhang, Jian Cui, Wei Xu, Xuyu Zhou, Jie Ma
Summary: The Split-Cre system allows for precise gene manipulation in cell subpopulations by improving recombinase activity through GFP-mediated dimerization and SpyTag/SpyCatcher conjugation. This dual-split system enhances gene expression control and provides advanced analysis of genes and cell functions in complex tissues like the immune system.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Giovanni Fajardo, Michael Coronado, Melia Matthews, Daniel Bernstein
Summary: Alterations in mitochondrial function and morphology are critical adaptations to cardiovascular stress, working in concert in an attempt to restore organelle-level and cellular-level homeostasis. Processes that alter mitochondrial morphology include fission, fusion, mitophagy, and biogenesis, and these interact to maintain mitochondrial quality control. Both pathological stressors like ischemia and physiological stressors like aerobic exercise can induce morphologic adaptations in mitochondria, but with different outcomes for mitochondrial health. Understanding the mechanisms underlying alterations in mitochondrial quality control under diverse cardiovascular stressors can aid in developing pharmacologic interventions for restoring cellular homeostasis.
Review
Cell Biology
Marina O. Gomzikova, Victoria James, Albert A. Rizvanov
Summary: Mitochondria donation plays a crucial role in treating mitochondrial diseases and deficiencies, leading to increased ATP production, restoration of function, and rescue of recipient cells. Mitochondrial dysfunction affects cells with high energy demands, and is associated with diseases such as type 2 diabetes, Parkinson's, and Alzheimer's.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Analytical
Chang Liu, Gongze Wang, Huan Ding, Ji Li, Yuanyuan Wu, Huirong Yao, Song He, Liancheng Zhao, Xianshun Zeng
Summary: The vinyl-bridged D-p-A structure of hemicyanine dye is sensitive to the change of microenvironmental viscosity, making it suitable for measuring viscosity change in living cells. A pyrene-and dehydropyridocolinium-containing fluorescent probe PyQz was developed for monitoring the change of viscosity in mitochondria during ferroptosis process, showing decreased solvatochromic effect and good chemical stability.
MICROCHEMICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Le Wang, Xin Huang, Taiqiang Dai, Jirong Xie, Qian-xin Lv, Yan Hou, Liang Kong, Yu Song, Fuwei Liu
Summary: This study investigated the impact of nano titanium surface on the mitochondrial fission-fusion dynamics of osteoblasts, revealing the crucial role of DRP1 and the significant decrease in osteogenic differentiation when DRP1 is inhibited. The findings provide insights for the design of titanium implant surface structures and highlight the importance of DRP1-regulated mitochondrial dynamics in accelerating osteogenic differentiation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Spectroscopy
Xiao-Lei Xue, Hao Zhang, Gui-Hua Chen, Guan-Hua Yu, Hao-Ran Hu, Shu-Yan Niu, Kun- Peng Wang, Zhi-Qiang Hu
Summary: There is a pressing need for the development of highly sensitive and selective fluorescence probes for ONOO- in mitochondria. In this study, we introduced a ratiometric fluorescent probe COUS, which utilized a coumarin-cyanine hybrid as the fluorophore and C = C bonds as reaction sites of ONOO-. The probe COUS displayed sensitivity and selectivity towards ONOO-, with a large fluorescence emission shift (239 nm) and a low detection limit (41.88 nM). Furthermore, COUS demonstrated mitochondrial targeting ability, and the targeting moiety could dissociate from the probe upon reaction with ONOO-, enabling accurate detection of ONOO- in mitochondria.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Review
Cell Biology
Evanthia Pangou, Izabela Sumara
Summary: Mitosis ensures genome integrity by precisely segregating genetic material, while also tightly coordinating the segregation of subcellular organelles, such as mitochondria, to meet energy demands and facilitate their efficient inheritance. Mitochondria, highly dynamic organelles, undergo fission, fusion, and transport events during the cell cycle, with kinases phosphorylating key factors to drive fragmentation for distribution to daughter cells. This review highlights the complex regulatory networks linking mitotic factors, mitochondrial dynamics, and potential implications in human disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Dan Li, Shengjie Yang, Yanwei Xing, Limin Pan, Ran Zhao, Yixi Zhao, Longtao Liu, Min Wu
Summary: Cardiovascular disease (CVD) is the leading cause of death globally, with atherosclerosis as its underlying pathological basis. Mitochondrial dynamics play a crucial role in CVD progression, impacting processes such as ROS production, oxidative stress, and inflammatory responses.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Jixiang Xing, Luyao Qi, Xiaofei Liu, Guangxi Shi, Xiaohui Sun, Yi Yang
Summary: Mitochondrial dynamics, including fusion and fission, play crucial roles in breast cancer by affecting metabolism, proliferation, survival, and metastasis. Understanding and manipulating mitochondrial dynamics is important for improving breast cancer treatments.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yicheng Wang, Pengwei Wang, Cong Li
Summary: Neurodegenerative diseases (NDs) lead to the progressive degeneration of neurons, with mitochondrial dysfunction playing a crucial role in neuronal loss. Visualizing mitochondrial abnormalities using fluorescence microscopy can help understand ND progression and develop new therapeutic strategies.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Cell Biology
Donnell White, Lothar Lauterboeck, Parnia Mobasheran, Tetsuya Kitaguchi, Antoine H. Chaanine, Qinglin Yang
Summary: A new fluorescent ATP indicator called smacATPi has been developed, allowing real-time visualization of ATP levels and dynamics in both the cytosol and mitochondria. This concept provides valuable insights into cellular metabolism and its response to metabolic changes.