Journal
MITOCHONDRION
Volume 9, Issue 2, Pages 79-85Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2009.01.001
Keywords
Adenine nucleotides; ADP/ATP carrier; ATP-Mg/Pi carrier; Mitocondrial membrane potential; ATP; Saccharomyces cerevisiae
Categories
Funding
- Ministerio de Educacion y Ciencia [BFU2005-C02-01, GEN2003-20235-C05-03/NAC]
- Comunidad de Madrid [S-GEN-0269-2006 MITOLAB-CM]
- European Union [LSHM-CT-2006-518153]
- CIBERER
- initiative of the ISCIII
- Fundacion Ramon Areces
- Ministerio de Ciencia e Innovacion
Ask authors/readers for more resources
The ADP/ATP and ATP-Mg/Pi carriers are widespread among eukaryotes and constitute two systems to transport adenine nucleotides in mitochondria. ADP/ATP carriers carry out an electrogenic exchange of ADP for ATP essential for oxidative phosphorylation, whereas ATP-Mg/Pi carriers perform an electroneutral exchange of ATP-Mg for phosphate and are able to modulate the net content of adenine nucleotides in mitochondria. The functional interplay between both carriers has been shown to modulate viability in Saccharomyces cerevisiae. The simultaneous absence of both carriers is lethal. In the light of the new evidence we suggest that, in addition to exchange of cytosolic ADP for mitochondrial ATP, the specific function of the ADP/ATP carriers required for respiration, both transporters have a second function, which is the import of cytosolic ATP in mitochondria. The participation of these carriers in the generation of mitochondrial membrane potential is discussed. Both are necessary for the function of the mitochondrial protein import and assembly systems, which are the only essential mitochondrial functions in S. cerevisiae. (C) 2009 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available