Journal
MITOCHONDRION
Volume 8, Issue 2, Pages 103-108Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2008.01.001
Keywords
deoxyribonucleotide transport; ThPP transport; HAART; AZT; antiviral toxicity; MCPHA; salvage pathway
Categories
Funding
- PHS HHS [RDK070533A] Funding Source: Medline
Ask authors/readers for more resources
We review the evidence that the function of the SLC25A19 gene product, previously identified as the mitochondrial deoxyribonucleotide carrier (DNC), is actually the transport of thiamine pyrophosphate. This evidence comes from enzyme kinetics, homologous yeast protein alignments, gene knockout studies, and clinical samples from Amish Microcephaly patients. This diverse body of evidence consistently points to the conclusion that SLC25A19 is not the true mitochondrial DNC gene. The identification of the correct mitochondrial DNC is important for research on the genetic diseases of mitochondrial DNA maintenance and the toxicity experienced by many HIV patients undergoing antiretroviral therapy involving nucleoside analogs. (c) 2008 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available