Editorial Material
Obstetrics & Gynecology
Dominique de Ziegler, Rene F. Frydman
Summary: Recurrent pregnancy loss (RPL) is defined as two to three spontaneous pregnancy terminations before 12 weeks of gestation, potentially caused by factors like gamete quality, uterine issues, endometrial receptivity alterations, immunologic factors, and thrombophilia.
FERTILITY AND STERILITY
(2021)
Review
Medicine, General & Internal
Julia Tomkiewicz, Dorota Darmochwal-Kolarz
Summary: Recurrent pregnancy loss is a common problem among reproductive age women and can be caused by various conditions. International guidelines, including those from RCOG, ASRM, and ESHRE, provide different approaches to its diagnosis and treatment. This review highlights the changing approach to miscarriages and the need for further exploration and refinement. It also addresses the challenge of unexplained pregnancy loss for clinicians.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Hind A. A. Alkhaldi, Duong H. H. Phan, Steven B. B. Vik
Summary: Recent advances in technology have made it possible to directly detect genetic diseases by determining the DNA sequence of genes. Researchers have simulated mitochondrial gene mutations in human cells and found that some of these mutations result in loss of function, which is valuable for genetic counseling.
Review
Medicine, General & Internal
Akbayan Turesheva, Gulzhanat Aimagambetova, Talshyn Ukybassova, Aizada Marat, Perizat Kanabekova, Lyazzat Kaldygulova, Ainur Amanzholkyzy, Svetlana Ryzhkova, Anastassiya Nogay, Zaituna Khamidullina, Aktoty Ilmaliyeva, Wassim Y. Almawi, Kuralay Atageldiyeva
Summary: Recurrent pregnancy loss is a complex health challenge with no universally accepted definition. The true incidence is difficult to estimate due to inconsistency in definitions and criteria applied by international guidelines. The exact etiology remains questionable and up to 75% of cases are unexplained. This review aimed to summarize accumulated knowledge on etiology, risk factors, diagnostic options, and management approach to recurrent pregnancy loss.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemical Research Methods
Xiang-Jie Yin, Wei Hong, Fu-Ju Tian, Xiao-Cui Li
Summary: Pregnancy is a complex process, and the regulation of the maternal-fetal interface is crucial for maintaining normal pregnancy. This study utilized iTRAQ technology and LC-MS/MS analysis to investigate the pathogenesis of RPL, revealing that the NDUFB3 protein is significantly increased in the decidua of RPL patients and may play an important role in the pathological process of RPL.
CLINICAL PROTEOMICS
(2021)
Review
Endocrinology & Metabolism
Ting Liu, Xi Guo, Ying Liao, Yingyu Liu, Yuanfang Zhu, Xiaoyan Chen
Summary: This review assesses the association between ANAs and RPL, as well as the effects of immunotherapy on pregnancy outcomes in women with positive ANAs and a history of RPL. It aims to provide a relevant reference basis for clinical application in this group of women.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Marie Carbonnel, Paul Pirtea, Dominique de Ziegler, Jean Marc Ayoubi
Summary: Both congenital and acquired uterine anomalies are associated with recurrent pregnancy loss. Initial evaluation of uterine anatomy is crucial for women with RPL. Surgical management of certain uterine anomalies, such as uterine septa, endometrial polyps, intrauterine adhesions, and submucosal myomas, may improve subsequent pregnancy outcomes in specific circumstances.
FERTILITY AND STERILITY
(2021)
Review
Endocrinology & Metabolism
Rosa Wartena, Mushi Matjila
Summary: The relationship between polycystic ovarian syndrome (PCOS) and recurrent pregnancy loss (RPL) is still poorly understood and requires further research. Factors that should be further investigated include the contribution of PCOS phenotypes, BMI, obesity, insulin resistance, hyperandrogenemia, SHBG, hs-CRP, CTRP6, adiponectin, plasma leptin, homocysteine, AMH, and thrombophilia to the risk of miscarriage. Other factors that need to be explored in relation to the risk of miscarriage in PCOS patients with RPL include sOB-R, PAI-Fx, and Factor-V-Leiden mutations.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Immunology
Qi Zhou, Yunhe Xiong, Bing Qu, Anyu Bao, Yan Zhang
Summary: DNA methylation plays a crucial role in the occurrence of RPL, while the maternal-fetal immune microenvironment is essential for maintaining pregnancy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Obstetrics & Gynecology
Diana Alecsandru, Amber M. Klimczak, Juan A. Garcia Velasco, Paul Pirtea, Jason M. Franasiak
Summary: Immunologic factors may contribute to miscarriages and recurrent pregnancy loss, with disruption of maternal-fetal immune homeostasis being a potential cause. Remodeling of maternal uterine spiral arteries is crucial for fetal development, ensuring adequate oxygen supply for proper placentation. Development of fetal tissues can lead to immunologic challenges, as the fetus may express paternal and gamete donor antigens, triggering a response from the maternal immune system.
FERTILITY AND STERILITY
(2021)
Article
Medicine, General & Internal
Rui Gao, Lang Qin, Peng Bai
Summary: The prevalence of self-reported depression is higher in women with recurrent pregnancy loss compared to healthy controls. Age ≥ 36 years, >2 times of spontaneous miscarriages, and no history of live birth are independent risk factors for self-reported depression in women with recurrent pregnancy loss.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Meryam Cheloufi, Alaa Kazhalawi, Anne Pinton, Mona Rahmati, Lucie Chevrier, Laura Prat-ellenberg, Anne-Sophie Michel, Geraldine Dray, Arsene Mekinian, Gilles Kayem, Nathalie Ledee
Summary: The study found that personalized strategies based on immune dysregulations, particularly through uterine immune profiling, are associated with higher rates of live births in women with a history of repeated pregnancy loss (RPL). Meanwhile, the use of ART may have a negative impact on live birth rates.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Obstetrics & Gynecology
Asher Bashiri, Mila Giliutin, Hanna Ziedenberg, Ygal Plakht, Yael Baumfeld
Summary: This retrospective cohort study aimed to develop a prognostic tool for predicting live birth rate in cases of repeated pregnancy losses. Data from 675 patients treated in a dedicated clinic between 2000 and 2015 were used to construct two prediction models. The results showed significant associations between live birth rate and factors such as age, number of previous pregnancy losses, primary/secondary RPL, and positive RPL workup. The tool can provide accurate information to couples and healthcare providers, reducing patient stress and allowing for personalized intervention programs.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Medicine, General & Internal
Asher Bashiri, Gabi Galperin, Atif Zeadna, Yael Baumfeld, Tamar Wainstock
Summary: This retrospective cohort study compared the live birth rates of women with and without progesterone treatment for recurrent pregnancy loss (RPL). The results showed that progesterone treatment was independently associated with a higher rate of live births in RPL patients. Further studies with larger sample sizes are recommended to confirm these findings.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Margarida Duarte, Cleide Ferreira, Gurleen Kaur Khandpur, Tamara Flohr, Jannik Zimmermann, Helena Castro, Johannes M. Herrmann, Bruce Morgan, Ana M. Tomas
Summary: The study shows that type II NADH dehydrogenase is essential in Leishmania parasites, even in the presence of complex I, while complex I can be dispensable in both species. This suggests unexplored functions for NDH2 and validates it as a candidate target for drugs against Leishmania parasites.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Susan Nabilou, Fatemeh Pak, Zahra Alizadeh, Mohammad Reza Fazlollahi, Masoud Houshmand, Maryam Ayazi, Iraj Mohammadzadeh, Mohammad Hasan Bemanian, Abbas Fayezi, Mohammad Nabavi, Shiva Saghafi, Sajedeh Mohammadian, Parviz Kokhaei, Mostafa Moin, Zahra Pourpak
Summary: This study aimed to define the genetic spectrum of HAE type I and type II among Iranian patients. Mutations in SERPING1 were analyzed using PCR and Sanger Sequencing, leading to the identification of 14 pathogenic variations, including 3 novel mutations. Genetic diagnosis plays a significant role in early diagnosis and prevention of potential risks associated with HAE.
IMMUNOLOGICAL INVESTIGATIONS
(2022)
Article
Environmental Sciences
Neda Gholami, Abasalt Hosseinzadeh Colagar, Mohammad Hossein Sinkakarimi, Farshad Sohbatzadeh
Summary: The study revealed significant effects of cold atmospheric pressure plasma jet on the regeneration ability of earthworms after 20 and 30 seconds of exposure. Although there were no significant effects on MDA content and TUNEL-positive cells, there were significant effects on TAC and CAT in both species.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Virology
Ali Fallah, Hadi Razavi Nikoo, Hamidreza Abbasi, Azadeh Mohammad-Hasani, Abasalt Hosseinzadeh Colagar, Ayyoob Khosravi
Summary: This review attempts to explain the features of SARS-CoV-2, particularly focusing on the various aspects of pathogenesis and treatment strategies.
Article
Neurosciences
Edgar Bermudez-Contreras, Andrea Gomez-Palacio Schjetnan, Artur Luczak, Majid H. Mohajerani
Summary: Repeated tactile or auditory stimulation selectively modifies the spatiotemporal patterns of cortical activity, mainly in the late evoked response. This modification lasts up to 60 minutes and only affects the evoked responses of the sensory modality receiving the repeated stimulation.
Article
Dentistry, Oral Surgery & Medicine
Amin Kalmari, Valiollah Arash, Abasalt Hosseinzadeh Colagar
Summary: This study assessed the association between COL2A1 gene polymorphisms and mandibular skeletal malocclusions in the population of Mazandaran, Iran. The results showed a positive correlation between COL2A1-G1405S polymorphism and mandibular retrognathism. Further analysis indicated that this polymorphism may disrupt the protein's domain. Therefore, studying COL2A1 gene polymorphisms can help understand the important role of this collagen in mandibular skeletal malocclusions.
ARCHIVES OF ORAL BIOLOGY
(2022)
Article
Neurosciences
Shakhawat R. Hossain, Hadil Karem, Zahra Jafari, Bryan E. Kolb, Majid H. Mohajerani
Summary: Alzheimer's disease is a major global health crisis, and current treatment options are limited. This study found that tactile stimulation can reduce symptoms and pathology in AD mice. Therefore, tactile stimulation may be a promising strategy for treating dementia in aging animals.
Article
Biology
Javad Karimi Abadchi, Zahra Rezaei, Thomas Knopfel, Bruce L. McNaughton, Majid H. Mohajerani
Summary: Coordinated peri-ripple activity in the hippocampal-neocortical network is crucial for brain's mnemonic processing. Neocortical activity in awake mice differed from that in sleep, with dominantly seen deactivation and activation in post-ripple voltage and glutamate activity, respectively. The peri-ripple modulation patterns of neocortical activity in sleep versus awake states might explain the functional differences observed in sleep versus awake ripples.
Review
Biochemistry & Molecular Biology
Lina Moallemi Rad, Mohammad Mehdi Sadoughi, Amir Nicknam, Abasalt Hosseinzadeh Colagar, Bashdar Mahmud Hussen, Mohammad Taheri, Soudeh Ghafouri-Fard
Summary: Eye disorders are common and have significant impacts on personal, economic, and social aspects of life. Dysregulation of non-coding RNAs, including lncRNAs, circRNAs, and miRNAs, is associated with the pathoetiology of these disorders. Several important lncRNAs, such as H19, MEG3, BANCR, UCA1, HOTAIR, ANRIL, XIST, and MIAT, as well as circRNAs from ZBTB44, HIPK3, circ-PSEN1, COL1A2, ZNF532, and FAM158A loci, have been found to play roles in ocular disorders. Both lncRNAs and circRNAs can function as molecular sponges for miRNAs. Research articles summarizing the impact of non-coding RNAs in ocular disorders were reviewed, and the findings can help identify potential targets for the treatment of these disorders.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Esmaeil Samadian, Abasalt Hosseinzadeh Colagar, Mahdieh Safarzad, Jahanbakhsh Asadi, Kamran Mansouri
Summary: The study investigated the impact of Urtica dioica agglutinin (UDA) on cellular vascularization processes. UDA inhibited cancer cell growth and vascularization while showing minimal toxicity to normal cells. UDA binds to glyco-conjugates containing GlcNAc/man oligomers to exert its anti-angiogenic activity, suggesting its therapeutic importance in angiogenesis-related treatments.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Cell Biology
Mojtaba Nazari, Javad Karimi Abadchi, Milad Naghizadeh, Edgar J. Bermudez-Contreras, Bruce L. McNaughton, Masami Tatsuno, Majid H. Mohajerani
Summary: Sleep consists of NREM and REM stages. Recent studies have found slow wave activity in local cortical regions during REM sleep. Using mesoscale imaging in mice, we mapped cortical activity gradients during REM sleep and found that slow waves mainly occur in somatomotor and auditory regions, with fewer occurrences in the default mode network. Additionally, we explored the role of the cholinergic system in local desynchronization during REM sleep.
Article
Biochemistry & Molecular Biology
Elaheh Mavadat, Bagher Seyedalipour, Saman Hosseinkhani, Abasalt Hosseinzadeh Colagar
Summary: Protein misfolding and amyloid formation are key features in diseases like ALS. By using two point mutations in hSOD1, we observed changes in charge distribution and stability. Our findings suggest that protein charge plays a role in ALS and the mutated protein differs significantly from the wild type. Moreover, the mutants showed an increase in amyloid-like aggregates under destabilizing conditions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biotechnology & Applied Microbiology
Mohammadkazem Heydari, Abasalt Hosseinzadeh Colagar, Davood Sabour
Summary: This study aims to optimize chitin affinity chromatography for the rapid purification of UDA lectin. Results showed that dissolving chitin in Trichloroacetic acid and attaching it to Sepharose 4B, as well as increasing column length, can improve the purification efficiency and concentration of UDA lectin, speeding up the process.
IRANIAN JOURNAL OF BIOTECHNOLOGY
(2023)
Article
Environmental Sciences
Fatemeh Fallah, Abasalt Hosseinzadeh Colagar, Hayder Abdulhadi Saleh, Mojtaba Ranjbar
Summary: This study investigated the association between enzymatic factors in semen, polymorphisms (SOD2 rs4880, GPX1 rs1050450, and CAT rs1001179), and male infertility. The results showed that the rs1050450 polymorphism was associated with a reduced risk of male infertility, asthenozoospermia, and teratozoospermia, while the rs4880 polymorphism was associated with an increased risk of male infertility and teratozoospermia.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Pediatrics
Mahshid Naserifar, Sahar Arab Yousefiabadi, Naser Vahdati Mashhadian, Mahshid Ataei, Nilufar Hashempour, Najmeh Jafari, Saeid Eslami, Zhila Taherzadeh
Summary: This study developed and validated a screening tool called POPI to assess rational prescriptions for pediatric patients in Iran. The tool was found to be effective in reducing the risk of inappropriate prescriptions in pediatrics.
IRANIAN JOURNAL OF PEDIATRICS
(2023)
Article
Genetics & Heredity
Parham Mardi, Bahareh Tavakoli-Far, Samira Sheibani Nia, Roshanak Jazayeri, Massoud Houshmand
Summary: This study aims to evaluate the frequency of three clinically significant CYP2B6 polymorphisms in three major Iranian ethnicities. The results show that Kurds have a higher risk of adverse drug reactions and insufficient anti-HIV response compared to other Iranians.
