Journal
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 11, Issue 8, Pages 678-694Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138955711796268804
Keywords
Lanthanides; therapeutic application; burn wounds; cancer; hyperphosphatemia; immune function; MRI contrast agents; osteoporosis
Categories
Funding
- Special Foundation for State Major New Drug Research Program of China [2009ZX09103-139]
- National Basic Research 973 Program [2010CB534913]
- National Natural Science Foundation of China [20971034]
- Hebei Province Nature Science Fund for Distinguished Young Scholars [B2011201164]
- Natural Science Key Foundation of Hebei Province [B2009000161]
- Natural Science Foundation of Hebei Province [B2011201135]
- Departement of Education of Hebei Province [ZD2010142]
Ask authors/readers for more resources
The biological properties of the lanthanides, primarily based on their similarity to calcium, have been the basis for research into potential therapeutic applications of lanthanides since the early part of the twentieth century. Up to date, cerium nitrate has been used as a topical cream with silver sulfadiazene for the treatment of burn wounds. A lanthanide texaphyrin complex (motexafin gadolinium) has been evaluated through Phase III clinical trials for the treatment of brain metastases in non-small cell lung cancer. Lanthanum carbonate (Fosrenol) as a phosphate binder has been approved for the treatment of hyperphosphatemia in renal dialysis patients in both the USA and Europe. This review will highlight therapeutic applications of the lanthanides for burn wounds, cancer, hyperphosphatemia, immune function, magnetic resonance imaging (MRI) contrast agents and osteoporosis, and discuss their future potential in the medical fields.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available