Article
Cell Biology
Natalia N. Bezborodkina, Sergey V. Okovityi, Boris N. Kudryavtsev
Summary: The study indicated that liver cirrhosis caused by chronic hepatitis results in alterations in glycogen metabolism, leading to a significant increase in glycogen content in hepatocytes in both humans and rats. This increase may be attributed to a decrease in glycogenolysis due to reduced activity of G6Pase and GP.
Article
Fisheries
Jiajie Tao, Yu Zhang, Dixin Wang, Xueluan Jiang, Yijun Liu, Naisong Chen, Songlin Li
Summary: The study found that the genes GYS2 and PYGL of largemouth bass are highly expressed in the liver, with their expression being affected by high dietary carbohydrate levels and the use of resveratrol.
AQUACULTURE REPORTS
(2021)
Article
Biology
Jordan Wesel, Cheryl Ingram-Smith
Summary: This article investigates the role of glycogen in the growth and adaptation of Entamoeba histolytica to a low-glucose environment. The synthesis and degradation of glycogen are found to be vital for the parasite's growth and encystation.
Article
Biotechnology & Applied Microbiology
Yu Dan, Jiahui Sun, Shanshan Zhang, Yannan Wu, Shaoming Mao, Guodong Luan, Xuefeng Lu
Summary: This study successfully regulated glycogen content in cyanobacteria by enhancing glycogen degradation, leading to increased sucrose production. These findings provide new insights into cyanobacterial glycogen metabolism engineering and will inspire the development of novel metabolic engineering approaches for efficient photosynthetic biosynthesis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Fisheries
Xiaotong Sun, Hongtao Nie, Xiwu Yan
Summary: This study identified and investigated three novel glycogen metabolism-related proteins in Manila clam, suggesting their potential involvement in innate immunity and important role in immune defense.
Article
Chemistry, Applied
Fen Li, Meng-Meng Wang, Qing-Hua Liu, Zhang-Wen Ma, Jun-Jiao Wang, Zi-Yi Wang, Jia-Wei Tang, Jing-Wen Lyu, Zuo-Bin Zhu, Liang Wang
Summary: This study investigates the important roles of two glycogen degradation enzymes in the structural alterations of glycogen in E. coli. The research concludes that glycogen phosphorylase plays a dominant role in glycogen structural stability control.
CARBOHYDRATE POLYMERS
(2023)
Article
Biochemistry & Molecular Biology
Zhiwei Yan, Shuai Li, Youde Wang, Jing Li, Can Ma, Yachun Guo, Liying Zhang
Summary: This study evaluates the effect of GP inhibitor as a potential pharmaceutical target on MI/R injury. The researchers designed and synthesized four different structural types of novel compounds, obtaining 31 novel GP inhibitors. Compound IIIh showed strong inhibitory activity against multiple subtypes of GP and exhibited obvious cardioprotective effect on MI/R injury mice in vivo. The discovery of compound IIIh provides a new strategy for developing novel GP inhibitors with myocardial ischemia protection.
BIOORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Mireia Diaz-Lobo, Josep Maria Fernandez-Novell
Summary: The study revealed that under gluconeogenic conditions, the gluconeogenic precursor DHA can increase G6P levels, activate GS, and promote its translocation, leading to an increase in glycogen deposition, similar to glucose.
JOURNAL OF CARBOHYDRATE CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Juliana C. Correa-Velloso, Paula J. Bartlett, Robert Brumer, Lawrence D. Gaspers, Henning Ulrich, Andrew P. Thomas
Summary: Rat hepatocytes express multiple purinergic P2Y and P2X receptors, leading to distinct Ca2+ oscillations. These oscillation patterns are shaped by protein kinase C, resulting in unique cellular responses to different agonists.
Article
Genetics & Heredity
Liu Yang, Zewen Sun, Jiuling Li, Xingchen Pan, Jianping Wen, Jianli Yang, Qing Wang, Peng Chen
Summary: Liver glycogen metabolism genes associated with PDFF were found not to be associated with NAFLD, suggesting a potential bias effect of glycogen storage on the quantification of liver fat content by PDFF.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
David L. Brautigan
Summary: Glycogen is a polymerized form of glucose used as an energy reserve in organisms. The synthesis and degradation of glycogen in animals, especially in the liver and skeletal muscle, is regulated by hormones and physiological signals that control the activities of glycogen synthase and glycogen phosphorylase. This article discusses the flash activation of phosphorylase in glycogen particles and suggests that the regulation of phosphatase in glycogen particles may involve hybrids of phosphorylase.
Article
Genetics & Heredity
Monica Villarreal-Salazar, Astrid Brull, Gisela Nogales-Gadea, Antoni L. Andreu, Miguel A. Martin, Joaquin Arenas, Alfredo Santalla, Alejandro Lucia, John Vissing, Thomas O. Krag, Tomas Pinos
Summary: In this study, the existing in vitro and in vivo preclinical models for McArdle disease are described, and the insights provided by these models are reviewed. Despite some differences from the typical patient phenotype, these models allow for a thorough study of the different features of the disease and serve as a necessary preclinical step to evaluate treatment efficacy and safety.
Article
Physiology
Jin-Hui Xu, Zhe Wang, Jun-Jie Mou, Chuan-Li Wang, Wei-Mei Huang, Hui-Liang Xue, Ming Wu, Lei Chen, Lai-Xiang Xu
Summary: The study found that huddling behavior may affect the increase in myocardial glycogen content of separated voles at lower temperatures, while the up-regulation of glucose transport and metabolism contributes to maintaining the stability of myocardial glycogen content in huddling voles.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Madhu Babu Pasula, Prabhat R. Napit, Abdulrahman Alhamyani, Sagor C. Roy, Paul W. Sylvester, Khaggeswar Bheemanapally, Karen P. Briski
Summary: The glucose transporter-2 (GLUT2) in astrocytes plays a sex-specific role in regulating glucose sensor function and glycogen metabolism. GLUT2 stimulates or inhibits glucokinase (GCK) expression in male astrocytes depending on glucose availability, but does not affect female astrocytes. GLUT2 also affects the expression of glycogen synthase (GS) and glycogen phosphorylase (GP) differently in males and females during glucose deprivation. Further research is needed to understand the molecular mechanisms underlying these sex-dimorphic effects.
NEUROCHEMICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Fabio Rinaldi, Anna Trink, Giorgia Mondadori, Giammaria Giuliani, Daniela Pinto
Summary: This article explores the relationship between menopause and changes in the hair follicle lifecycle, focusing on hormone and metabolic dynamics. Hormonal fluctuations and aging during menopause can affect the hair follicles, leading to thinning, reduction in volume, and changes in hair texture. These changes are primarily caused by a decrease in estrogen levels. However, not all women experience significant hair changes during menopause, and the extent of transformations can vary greatly due to genetic factors, stress, diet, and other elements. Additionally, menopause affects metabolism and blood flow to the hair follicles, affecting the availability of essential nutrients. The article also discusses the role of energy metabolism in the hair follicle lifecycle and the impact of hormones, especially estrogens, on metabolic efficiency. The concept of a possible menopause clinically independent of menopause is introduced, which is related to changes in hair follicle metabolism, highlighting the importance of individual factors such as estrogen receptor responses, genetics, and the microbiota in determining these dynamics.