Journal
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 9, Issue 3, Pages 368-378Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389557510909030368
Keywords
Lysophospholipids; Phospholipids; Lysophosphatidylcholine; Phospholipase; Reactive Oxygen Species; Inflammation; Disease Markers; Signaling Molecules
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The concentration of lysophospholipids (LPL) increases under pathological conditions and, thus, LPL attract diagnostic and pharmacological interest. LPL are particularly interesting because they possess pro- and anti-inflammatory properties and can be generated by phospholipases and reactive oxygen species (ROS). This review provides an overview of the mechanisms by which LPL are generated and how they can be determined. The effects of LPL as signaling molecules and their roles in different pathologies are discussed. The focus will be on lysophosphatidylcholine (LPC).
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