Journal
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 8, Issue 10, Pages 976-995Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138955708785740661
Keywords
dopamine receptor ligands; D-1 subtype; D-5 subtype; structure-activity relationship (SAR); pharmacophore
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Due to the lack of highly selective dopamine D-1 or D-5 receptor ligands, only few data about activation or blocking of these receptor subtypes are available. The present review collects the available information about molecules with notable affinity for D5 receptor subtype with the purpose to help the researchers to design novel D5 selective ligands, whose discovery may enrich the knowledge about the physiological function of such a receptor, provide information about its topography, as well as lead to novel potential therapeutic tools.
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