Journal
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 8, Issue 11, Pages 1163-1178Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138955708785909880
Keywords
G-quadruplex; G-quartet; ligands; substituted derivatives; affinity and selectivity; DNA interactions; telomerase inhibition
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Funding
- National Natural Science Foundation of China [20472117]
- Science Foundation of Zhuhai [PC20041131]
- Hong Kong Polytechnic University
- Shenzhen Science and Technology Fund
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G-quadruplex structures are promising targets for design of cancer drugs with high selectivity and low toxicity. This review provides an update of the progress made over the last few years in the design of selective G-quadruplex ligands, and a comprehensive summary of the major design strategies and structural characteristics.
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