Review
Pharmacology & Pharmacy
Berenger Largeau, Jean-Luc Cracowski, Celine Lengelle, Benedicte Sautenet, Annie-Pierre Jonville-Bera
Summary: Drug-induced peripheral edema can occur through various mechanisms, such as vasodilatory edema, renal edema, lymphedema, and permeability edema. Different drugs may cause different types of peripheral edema, which may be underestimated and misdiagnosed, leading to inappropriate prescribing.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
S. Gianesini, E. Rimondi, J. D. Raffetto, E. Melloni, A. Pellati, E. Menegatti, G. P. Avruscio, F. Bassetto, A. L. Costa, S. Rockson
Summary: Blood flow is translated into biochemical signals in response to shear stress, which is recognized by sensitive endothelial receptors and plays a vital role in understanding vascular remodeling. While the role of glycocalyx structures in veins and arteries is known, the presence of such structures in the lymphatic system has not been identified in humans.
SCIENTIFIC REPORTS
(2023)
Review
Chemistry, Medicinal
Kazuaki Taguchi, Yuko Okamoto, Kazuaki Matsumoto, Masaki Otagiri, Victor Tuan Giam Chuang
Summary: Albumin as a drug delivery agent offers exceptional drug-binding capacity and biocompatibility for optimizing drug delivery systems. Many albumin-containing liposome preparations have been developed, showing superior deliverability for genes, hydrophilic/hydrophobic substances, and proteins/peptides compared to original liposomes.
Article
Pharmacology & Pharmacy
Tian Zhao, Libin Zhan, Wen Zhou, Wanxin Chen, Jintong Luo, Lijing Zhang, Zebin Weng, Chunyan Zhao, Shenlin Liu
Summary: The study found that Erchen Decoction (ECD) can reduce body weight, improve insulin resistance (IR) and lipid metabolism by interfering with specific signaling pathways in Zucker diabetic fatty (ZDF) rats. Additionally, ECD was shown to adjust the structure of gut microbiota and change its function in ZDF rats, demonstrating a potentially close relationship between specific biomarkers, metabolites, and host phenotypes. The results suggest that ECD's beneficial effects on obesity, particularly lipid metabolism disorders, are linked to regulation of gut microbiota in ZDF rats, providing a foundation for further research on its mechanisms and clinical applications.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ryo Kinoshita, Yu Ishima, Victor T. G. Chuang, Hiroshi Watanabe, Taro Shimizu, Hidenori Ando, Keiichiro Okuhira, Masaki Otagiri, Tatsuhiro Ishida, Toru Maruyama
Summary: Human serum albumin (HSA) is a versatile drug carrier with active tumor targeting capacity, especially in delivering antitumor drugs. HSA dimer (HSA-d) has been found to be more effective in tumor distribution and can improve the efficacy of nanotechnology. HSA-d-doxorubicin (HSA-d-DOX) shows significantly higher cytotoxicity in vitro and inhibits tumor growth in human pancreatic tumors.
Article
Biochemistry & Molecular Biology
Eva Tvrda, Jan Kovac, Kristina Ferenczyova, Barbora Kalocayova, Michal Duracka, Filip Benko, Viera Almasiova, Monika Bartekova
Summary: The aim of this study is to investigate the effects of quercetin on testicular architecture and markers of oxidative, inflammatory, and apoptotic profile in Zucker diabetic fatty rats with Type 2 diabetes mellitus. The results showed that quercetin improved testicular appearance, stabilized antioxidant capacity, decreased lipid peroxidation, and reduced inflammation levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Integrative & Complementary Medicine
Yajing Li, Jiaojiao Chen, Haiye Tu, Quanxin Ma, Mulan Wang, Jie Chen, Minli Chen
Summary: In this study, it was found that GuanXinNing Tablet (GXNT) has a highly satisfactory protective effect on diabetic encephalopathy (DE) in ZDF rats. Its mechanism of action may be based on the regulation of glucolipid metabolism and its protective effect on the vascular endothelium.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Biochemistry & Molecular Biology
Barbora Bot'anska, Monika Bartekova, Kristina Ferenczyova, Maria Fogarassyova, Lucia Kindernay, Miroslav Barancik
Summary: This study revealed that obesity worsened heart function with changes in MMP-2, MMP-28, and SODs, which were not modulated by QCT treatment. However, QCT activated Akt kinase and prevented diabetes-induced negative effects on SODs, suggesting its potential in mediating adaptive responses against oxidative stress in diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Tiannan Wang, Xia Tang, Xinge Hu, Jing Wang, Guoxun Chen
Summary: The study found that reducing dietary vitamin A status can prevent the development of type 2 diabetes and obesity in ZDF rats, especially in high-fat diets.
Article
Chemistry, Medicinal
Kyung-A Byun, Seyeon Oh, Myeongjoo Son, Chul-Hyun Park, Kuk Hui Son, Kyunghee Byun
Summary: It was found in this study that ECE and DK can attenuate NAFLD by decreasing weight gain and food intake, reducing inflammation, increasing lymphangiogenesis, and modulating lymphatic vessel permeability.
Article
Neurosciences
Shuxing Wang, Shaoyuan Li, Xu Zhai, Peijing Rong, Jietao He, Lina Liu, Xinxin He, Wenguo Liu
Summary: Type 2 diabetes (T2D) and COVID-19 are both associated with decreased levels of melatonin, and chronic pain is a common symptom in patients with both conditions. This study found that transcutaneous auricular vagal nerve stimulation (taVNS) can increase melatonin concentration, upregulate melatonin receptors (MTRs), and relieve peripheral neuropathic pain. The therapeutic effect of taVNS is mediated by the release of extrapineal melatonin and the positive regulation of central MTR expression. Therefore, taVNS may be beneficial for managing chronic pain in individuals with diabetes during COVID-19 rehabilitation.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yaoqing Wang, Xiao Zhang, Haoya Yao, Xiaocui Chen, Lin Shang, Ping Li, Xiaojuan Cui, Jia Zeng
Summary: This study investigates the mechanism behind lipid and reactive oxygen species (ROS) accumulation in diabetic kidneys and proposes a role for succinate in inducing these accumulations. Specifically targeting peroxisomal beta-oxidation can improve diabetic nephropathy by reducing succinate generation and attenuating lipid and ROS accumulation.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Xufeng Wang, Xiangjun Sun, Abulikemu Abulizi, Jinyao Xu, Yun He, Qian Chen, Ruicheng Yan
Summary: SalA treatment can improve insulin resistance, liver injury, and lipid metabolism in ZDF rats, while promoting the diversity and homeostasis of intestinal microbiota.
DIABETOLOGY & METABOLIC SYNDROME
(2022)
Article
Endocrinology & Metabolism
Ying Wang, Haiyi Liu, Miaoyan Zheng, Yanhui Yang, Huizhu Ren, Yan Kong, Shanshan Wang, Jingyu Wang, Yingying Jiang, Juhong Yang, Chunyan Shan
Summary: Berberine may be beneficial in slowing down the progression from prediabetes to type 2 diabetes mellitus in ZDF rats by improving GLP-2 secretion, intestinal permeability, and gut microbiota structure.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Kang Chen, Xuetao Wei, Jian Zhang, Maaria Kortesniemi, Yumei Zhang, Baoru Yang
Summary: The effect of nonacylated and acylated anthocyanins on urinary metabolites in diabetic rats was investigated. The study found that both types of anthocyanins modulated the metabolites associated with the tricarboxylic acid cycle, gut microbiota metabolism, and renal function. Additionally, a high dose of acylated anthocyanins improved energy production in mitochondria, glucose homeostasis, and oxidative stress.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Endocrinology & Metabolism
E. Cosson, E. Vicaut, D. Sandre-Banon, F. Gary, I Pharisien, J-J Portal, C. Baudry, C. Cussac-Pillegand, D. Costeniuc, P. Valensi, L. Carbillon
DIABETES & METABOLISM
(2020)
Letter
Endocrinology & Metabolism
Emmanuel Cosson, Eric Vicaut, Jean-Jacques Portal, Lionel Carbillon, Paul Valensi
Article
Cardiac & Cardiovascular Systems
Amel Rezki, Marinos Fysekidis, Sabrina Chiheb, Eric Vicaut, Emmanuel Cosson, Paul Valensi
Summary: The study demonstrated that saxagliptin has metabolic benefits in glucose-intolerant obese patients by significantly reducing postprandial blood glucose levels, leading to an improvement in glucose tolerance.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Nutrition & Dietetics
Lucie Allard, Elise Ouedraogo, Julie Molleville, Helene Bihan, Benedicte Giroux-Leprieur, Angela Sutton, Camille Baudry, Constant Josse, Morgane Didier, David Deutsch, Olivier Bouchaud, Emmanuel Cosson
Article
Medicine, General & Internal
Charlotte Nachtergaele, Eric Vicaut, Sopio Tatulashvili, Sara Pinto, Helene Bihan, Meriem Sal, Narimane Berkane, Lucie Allard, Camille Baudry, Jean-Jacques Portal, Lionel Carbillon, Emmanuel Cosson
Summary: The study evaluated proposals to limit the number of OGTTs for diagnosing HIP during the COVID-19 pandemic from Australian-New Zealand Societies, with Option 2 showing the best balance in terms of required OGTT, sensitivity, and rates of a composite outcome.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Emmanuel Cosson, Sid Ahmed Bentounes, Charlotte Nachtergaele, Narimane Berkane, Sara Pinto, Meriem Sal, Helene Bihan, Sopio Tatulashvili, Jean-Jacques Portal, Lionel Carbillon, Eric Vicaut
Summary: This study compared pregnancy outcomes in 4665 women based on different sub-types of hyperglycaemia in pregnancy. Early-diagnosed hyperglycaemia was associated with an increased risk of infant malformation, while women with GDM had an increased risk of having a large-for-gestational-age infant. Women with DIP might benefit from surveillance for hypertensive disorders.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Endocrinology & Metabolism
Fernando Gomez-Peralta, Pratik Choudhary, Emmanuel Cosson, Concetta Irace, Birgit Rami-Merhar, Alexander Seibold
Summary: Laboratory measured glycated haemoglobin (HbA1c) is the gold standard for assessing glycaemic control, but continuous glucose monitoring (CGM) has revealed limitations of HbA1c testing. The glucose management indicator (GMI) is proposed as a substitute, calculated exclusively from CGM data, but it can differ from HbA1c values.
DIABETES OBESITY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Dan Yedu Quansah, Justine Gross, Leah Gilbert, Amelie Pauchet, Antje Horsch, Katrien Benhalima, Emmanuel Cosson, Jardena J. Puder
Summary: Compared with classical gestational diabetes (cGDM), early gestational diabetes (eGDM) is not associated with differences in mental health but is associated with adverse cardiometabolic outcomes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Dan Yedu Quansah, Sara De Giorgi, Olivier Le Dizes, Chiara Camponovo, Katrien Benhalima, Emmanuel Cosson, Jardena J. Puder
Summary: RH is frequent in women with a history of GDM at 6-8 weeks postpartum and is associated with a better metabolic profile. RH may be a marker of favorable metabolic prognosis in women with a history of GDM.
Article
Endocrinology & Metabolism
Emmanuel Cosson, Eric Vicaut, Sopio Tatulashvili, Jean -Jacques Portal, Charlotte Nachtergaele, Meriem Sal, Narimane Berkane, Sara Pinto, Amel Rezgani, Lionel Carbillon, Helene Bihana
Summary: This study aims to evaluate the risk of large-for-gestational-age (LGA) infants in women with gestational diabetes mellitus (GDM) and found no residual risk of LGA infants in women treated for GDM.
DIABETES & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Emmanuel Cosson, Narimane Berkane, Sara Pinto, Helene Bihana, Sopio Tatulashvili, Michael Soussan, Nicolas Sellier, Minh Tuan Nguyen, Paul Valensi
Summary: This study aimed to explore the proportion and direction of coronary artery calcium (CAC) score reclassification in asymptomatic diabetic patients at high coronary risk, as well as the sensitivity of screening for myocardial ischemia/coronary stenosis in high-risk patients. The results showed that 66% of high-risk patients were reclassified into the moderate risk category, leading to less stringent risk factor control goals. Additionally, 18% of the patients were reclassified into the very high-risk category, resulting in 100% sensitivity for detecting patients with ischemia and coronary stenosis.
DIABETES & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Michael Vallis, Hana Ryan, Lori Berard, Emmanuel Cosson, Finn Boerlum Kristensen, Fleur Levrat-Guillen, Nicolas Naiditch, Remi Rabasa-Lhoret, William Polonsky
Summary: The use of continuous glucose monitoring (CGM) devices can improve glycemic control and motivate self-management behaviors in people with type 2 diabetes (PwT2D). CGM technology has a profound impact on various aspects of self-management and care for PwT2D, but there are also negative experiences and concerns associated with it. Developing a validated instrument to assess these constructs could help develop interventions and fully leverage the benefits of CGM technology.
CANADIAN JOURNAL OF DIABETES
(2023)
Article
Endocrinology & Metabolism
Emmanuel Cosson, Sopio Tatulashvili, Eric Vicaut, Sara Pinto, Meriem Sal, Charlotte Nachtergaele, Narimane Berkane, Amelie Benbara, Marion Fermaut, Jean-Jacques Portal, Lionel Carbillon, Helene Bihan
Summary: Prognosis of treated hyperglycemia in pregnancy (HIP) may differ depending on whether the diagnosis is based on high fasting and/or high post-load glucose values. This study found that isolated fasting HIP was associated with a higher rate of large-for-gestational-age (LGA) infants, while post-load HIP was associated with higher rates of preterm delivery and neonatal intensive care unit admission.
DIABETES & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Mamadou Adama Sow, Guillaume Treiber, Emmanuel Cosson, Yves Mutunzi, Julien Magne, Cyrille Boulogne, Laurence Salle, Marouane Boukhris, Estelle Nobecourt, Victor Aboyans
Summary: This study identified the determinants of high coronary artery calcium score (CACS) in CVD-free patients with Type-2 diabetes (T2D). The risk factors for high CACS include age, sex, diabetes duration, non-CV end-organ damage, and presence of other cardiovascular disease (CVD) risk factors. The French-CAC100 score allows for the identification of patients at higher risk of elevated CACS and can help reduce unnecessary CT scans.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Endocrinology & Metabolism
Emmanuel Cosson, Elhadji Mamadou Moussa Thioye, Sopio Tatulashvili, Eric Vicaut, Etienne Larger, Meriem Sal, Sara Pinto, Emmanuelle Fabre, Yoann Lalatonne, Angela Sutton, Charlotte Nachtergaele, Jean-Jacques Portal, Mohamed Zerguine, Lionel Carbillon, Helene Bihan
Summary: This study explored the association between the presence of glutamic acid decarboxylase antibodies (GADA) and other adverse pregnancy outcomes in women with hyperglycemia in pregnancy (HIP). The results showed that GADA was not associated with HIP-related adverse pregnancy outcomes except for a lower risk of cesarean delivery.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Peripheral Vascular Disease
Jingting Yao, Justin D. Sprick, Jinhee Jeong, Jeanie Park, David A. Reiter
Summary: This study used time-frequency spectral analysis of resting near-infrared spectroscopy (NIRS) signals to evaluate the regulation of peripheral microvascular perfusion in CKD patients. The findings suggest that CKD patients have impaired neurogenic and endothelial functions, which may be associated with increased sympathetic activity and reduced endothelial function in CKD.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Yoh Sugawara, Yusuke Mizuno, Shinya Oku, Yuri Sawada, Takahisa Goto
Summary: This study investigated the role of Protein kinase D (PKD) in aortic contraction and hemodynamics, finding that PKD1 plays a crucial role in these processes through phosphorylation of MYPT1 and actin polymerization in a calcium-independent manner.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Xuenan Zhuang, Guiqin He, Yunkao Zeng, Miaoling Li, Yongyue Su, Xuelin Chen, Yining Zhang, Yuhong Gan, Feng Wen, Xiongze Zhang
Summary: This study assessed the impact of acute, heavy alcohol consumption on the ocular microvasculature. The findings suggest that excessive alcohol consumption leads to vasoconstriction in ocular arterioles and vasodilation in capillaries, particularly evident 1-hour post-consumption.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Ayuki Nakano, Akane Morita, Shiho Arima, Tohru Nagamitsu, Tsutomu Nakahara
Summary: This study examines the preventative and therapeutic effects of inhibiting mammalian target of rapamycin complex 1 (mTORC1) on abnormal retinal blood vessels in a rat model of retinopathy of prematurity (ROP). The results suggest that mTORC1 activation in proliferating endothelial cells contributes to the appearance and progression of ROP-like retinal blood vessels. Inhibition of mTORC1 may be a promising approach for selectively targeting abnormal retinal blood vessels in ROP.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Bing Wang, Xiaohong Song, Xu Zhang, Yuan Li, Mengting Xu, Xueting Liu, Bingwei Li, Sunjing Fu, Hao Ling, Yingyu Wang, Xiaoyan Zhang, Ailing Li, Mingming Liu
Summary: This study found that glycine supplementation can improve pancreatic microcirculation in T1DM mice and reverse the production of inflammatory cytokines. Furthermore, glycine supplementation also alleviates damage to pancreatic islet and vascular tissues, suggesting a potential therapeutic effect for T1DM.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Merve Erkisa Genel, Kaan Adacan, Selin Selvi, Deniz Erol Kutucu, Ayca Uvez, Elif Ilkay Armutak, Abdurrahman Sengul, Engin Ulukaya, Ebru Gurel Gurevin
Summary: This study investigated the anti-growth/cytotoxic effect of a dinuclear Pd(II) complex on breast cancer cell lines and confirmed its anti-migration and antiangiogenic properties. The results suggest the potential of this complex in the treatment of breast cancer.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Cedric Mueller, Christoph Hauser, Justin Carrard, Konstantin Gugleta, Timo Hinrichs, Arno Schmidt-Trucksass, Henner Hanssen, Lukas Streese
Summary: This study aimed to evaluate the differences in microvascular health between normotensive individuals and patients with arterial hypertension and to assess the effects of short-term high-intensity interval training (HIIT) on microvascular health in patients with arterial hypertension. The study found that short-term HIIT can ameliorate hypertension-induced retinal microvascular abnormalities in patients with arterial hypertension.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Yuyang Hou, Wenjing Du, Qiong Wu, Xinyu Chai, Yinan Wang, Yingqian Mi, Yuan Tian, Mengyan Tang, Jun Li, Dongmei Yan
Summary: This study identified a prognostic signature consisting of four genes in bladder cancer patients and utilized angiogenesis-related genes and molecular subtypes to construct this signature, which could help predict survival outcomes. The study also evaluated immune cell infiltration and predicted chemotherapeutic responses, confirming the effectiveness of this prognostic signature.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Sean D. Mcgarry, Cynthia Adjekukor, Suchit Ahuja, Jasper Greysson-Wong, Idy Vien, Kristina D. Rinker, Sarah J. Childs
Summary: The article introduces a software tool called Vessel Metrics for analyzing developmental vascular microscopy images, which can expedite the analysis process and ensure consistency between research groups. The tool includes a segmentation algorithm that accurately quantifies different image types and has been validated in zebrafish and mouse models.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Y. P. Latul, C. Ince, N. E. van Trommel, A. van den Brandhof-van den Berg, J. P. W. R. Roovers, A. W. Kastelein
Summary: This study evaluated the real-time detection capability of handheld vital microscopy (HVM) for cervical intraepithelial neoplasia (CIN) and cervical cancer (CC). The results showed that HVM enables easy, real-time, and non-invasive assessment of cervical lesions through the detection of microvascular alterations. This method has the potential to be used for point-of-care screening, reducing unnecessary surgical interventions.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Zhifei Liu, Jieqiong Zhang, Xue Li, Qiumei Hu, Xi Chen, Linlin Luo, Liqianyu Ai, Jian Ye
Summary: The study revealed that astrocytic YAP can alleviate retinal pathological angiogenesis by inhibiting overactivation of astrocytes, thereby suppressing excessive VEGF-A production and neuroinflammation.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Robert G. Hahn
Summary: The fast-exchange interstitial fluid compartment is directly connected to the circulating blood, while the slow-exchange compartment is not.
MICROVASCULAR RESEARCH
(2024)
Review
Peripheral Vascular Disease
Nadia Hamjane, Mohcine Bennani Mechita, Naima Ghailani Nourouti, Amina Barakat
Summary: Gut microbiota dysbiosis plays a crucial role in the development of obesity-related metabolic abnormalities, including insulin resistance, type 2 diabetes, and cardiovascular diseases. Inflammation is a major mechanism linking gut microbiota dysbiosis to obesity-associated metabolic complications.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Guangzhen Zhou, Yan Gao, Yanbin Shi, Shengnan Qiu, Guimei Lin, Xinbing Ding, Wenguang Wang, Yihua Feng, Fei Wang, Jinwei Qiao
Summary: This study utilized an in vitro biomimetic experimental system to investigate the transvascular transport of nano-preparations, and found that the pressure gradient between vascular fluid pressure and interstitial fluid pressure determines the existence of the enhanced penetration and retention effect of nanopreparations.
MICROVASCULAR RESEARCH
(2024)
Article
Peripheral Vascular Disease
Kenji Chamoto, Barry C. Gibney, Willi L. Wagner, Maximilian Ackermann, Hassan A. Khalil, Steven J. Mentzer
Summary: In the study, the process of angiogenesis in adult regenerating tissue was investigated by grafting portions of the regenerating lung onto the chick chorioallantoic membrane. The results showed peri-graft angiogenesis, particularly in the cardiac lobe. Functional vascular connections were observed between the cardiac lobe and the chick chorioallantoic membrane vascular network. Elevated gene expression levels were found in the cardiac lobe compared to other lobes.
MICROVASCULAR RESEARCH
(2024)
