Article
Engineering, Environmental
Thi Phuc Le, Yang Yu, Hyuk Chan Kwon, Sun-Ae Shin, Yong-Ho Park, Kang Moo Huh
Summary: This study introduces a self-degradable prodrug blend thermogel system for the treatment of inner ear diseases. The system exhibits excellent thermogelling and controlled release characteristics, resulting in enhanced drug absorption and prolonged drug concentration in the inner ear. In a guinea pig model, significant hearing recovery was observed within 7 days after noise exposure.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Bo Hu, Jinyuan Gao, Yu Lu, Yuji Wang
Summary: Hydrogels are suitable materials for loading drug delivery agents due to their high water content and cross-linked nature. Biodegradable hydrogels have become a promising technology in disease treatment and drug delivery methods due to their advantageous properties.
Article
Biochemistry & Molecular Biology
Ralph J. S. van Mechelen, Jarno E. J. Wolters, Sebastian Fredrich, Christian J. F. Bertens, Marion J. J. Gijbels, Albert P. H. J. Schenning, Leonard Pinchuk, Theo G. M. F. Gorgels, Henny J. M. Beckers
Summary: Fibrosis of the filtering bleb is a common cause of failure in bleb-forming glaucoma surgery. This study investigates the use of a sustained-release drug delivery system (DDS) loaded with mitomycin C (MMC) to reduce fibrosis. Two different MMC-loaded DDSs are tested and compared to a control group. The results show that both DDSs release a significant amount of MMC and maintain functioning blebs, but the PLGA DDS exhibits less inflammation and more complete degradation compared to the PCL DDS.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Huw D. Summers, Carla P. Gomes, Aida Varela-Moreira, Ana P. Spencer, Maria Gomez-Lazaro, Ana P. Pego, Paul Rees
Summary: The study utilized data simulation techniques to model nanoparticle drug delivery processes, revealing the dynamic nature of dose variation over time, including supply time constant and degradation rate constant. The model successfully replicated the dynamic changes in cell-to-cell dose variation.
Article
Materials Science, Biomaterials
Niping Deng, Jinghang Li, Hao Lyu, Ruochuan Huang, Haoran Liu, Chengchen Guo
Summary: This study fabricates protein-based soft actuators with magnetic responsiveness using naturally occurring silk proteins and synthesized Fe3O4 magnetic nanoparticles. The results show that the soft actuators have good stretchability, mechanical properties matching soft tissues, degradability, biocompatibility, and in vivo X-ray visibility. The soft actuators can be actuated and used for localized drug delivery by attaching a magnet. These degradable silk-based soft actuators provide significant opportunities for improving current therapeutic strategies in biomedicine.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Pharmacology & Pharmacy
Selin S. Suner, Mehtap Sahiner, Ramesh S. Ayyala, Nurettin Sahiner
Summary: Non-degradable, slightly degradable, and completely degradable micro/nanoparticles derived from chondroitin sulfate (CS) were synthesized. The CS particles with tunable degradation ability showed sustainable release of antibiotics with improved biocompatibility for the treatment of bacterial keratitis.
Article
Engineering, Multidisciplinary
Sung Jun Min, Jae Seo Lee, Haram Nah, Ho-Jin Moon, Sang Jin Lee, Hyeon Jeong Kang, Yu-Shik Hwang, Il Keun Kwon, Dong Nyoung Heo
Summary: Biodegradable hydrogels have great potential as biomaterials for controlled-release systems in skin tissue regeneration. In this study, keratin-based hydrogels were synthesized and their properties were investigated for controllable protein delivery. The results showed that these hydrogels exhibited promising biological performance and could serve as suitable carriers for controlled protein delivery.
JOURNAL OF BIONIC ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Bianka Golba, Matthieu Soete, Zifu Zhong, Niek Sanders, Filip E. Du Prez, Hannes A. Houck, Bruno G. De Geest
Summary: By modifying polyethylene glycol (PEG) with 1,2,4-triazoline-3,5-diones (TAD) under green light, we achieved both functionality and degradability of the PEG backbone. The TAD-PEG conjugates are degradable in aqueous medium under physiological conditions, with degradation rate depending on pH and temperature. Using TAD-derivatized PEG-lipid, we successfully improved messenger RNA (mRNA) transfection efficiency in vitro, and observed a similar tissue distribution in mice in vivo. These findings open up possibilities for the design of degradable, backbone-functionalized PEG in nanomedicine and beyond.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Analytical
Ajay Prabhakar Attiguppe, Dhiman Chatterjee, Amitava DasGupta
Summary: Transdermal drug delivery (TDD) has made significant progress in recent years, allowing targeted microdosing, bespoke treatment regimens, and improved drug adherence. The use of polymers in drug delivery is increasing due to their low cost, scalability, ease of manufacture, and compatibility. This study presents the design and development of a polymer-based TDD platform fabricated using additive manufacturing technologies, including a 3D-printed micropump, drug reservoir, and hollow microneedle array. This integrated system demonstrates efficient drug delivery with minimal moving parts and can be easily fabricated using additive manufacturing technologies.
Article
Materials Science, Biomaterials
Xinming Li, Peng Liu
Summary: Polyprodrugs with drugs as the structural units are a promising drug self-delivery system for tumor chemotherapy. An acid/reduction co-triggered degradable amphiphilic copolyprodrug was designed, which showed enhanced inhibition of tumor growth and good cytocompatibility.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Polymer Science
Ming Zhang, Daai Li, Pengfei Shan, Xiaoyue Lian, Yuxi Qi, Kaicheng Du, Guoquan Ma, Liang Cai, Zhihui Li, Zhongyu Li
Summary: A dithiol reagent containing ketal and o-nitrobenzyl structures was used to synthesize the polymer PKNB and the amphiphilic triblock copolymer mPEG-PKNB-mPEG through thiol-ene click chemistry. The mPEG-PKNB-mPEG and its nanoparticles exhibited excellent light/acid degradation ability, suggesting promising applications in drug, gene, or pesticide delivery.
Article
Materials Science, Multidisciplinary
Jun Xu, Tiantian Hao, Changlin Liu, Jingjing Bi, Jing Sun, Zheng Wen, Zhaosheng Hou, Jinjian Wei
Summary: A new type of pH-responsive block polyurethane (PMCU) was synthesized in this study, showing good tensile properties and pH responsiveness, making it a promising platform for targeted drug delivery in biomedical areas.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Materials Science, Multidisciplinary
Tarik Rust, Dimitri Jung, Axel Hoppe, Timo Schoppa, Klaus Langer, Dirk Kuckling
Summary: The study synthesized a series of light-responsive polymers that can degrade rapidly in solution, enabling precise drug release and improved therapeutic effects.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Emily Dosmar, Gabrielle Vuotto, Xingqi Su, Emily Roberts, Abigail Lannoy, Garet J. Bailey, William F. Mieler, Jennifer J. Kang-Mieler
Summary: This study utilized computational and 3D models to investigate antibiotic drug transport from a hydrogel drug delivery system to the eye. Different routes of drug administration showed varying times to reach peak concentrations in the vitreous, but all successfully achieved therapeutic levels. These models could potentially be used to optimize drug loading doses in the delivery system to minimize drug use and waste.
Article
Pharmacology & Pharmacy
Leila Mousavifar, Jordan D. Lewicky, Alexis Taponard, Rahul Bagul, Madleen Rivat, Shuay Abdullayev, Alexandrine L. Martel, Nya L. Fraleigh, Arnaldo Nakamura, Frederic J. Veyrier, Hoang-Thanh Le, Rene Roy
Summary: This study reports the chemical synthesis of a novel series of mannosylated neoglycolipids with the goal of further improving on the previous glyconanoparticles. By using a new synthetic method, stable neoglycoliposomes were successfully prepared, and their potential applications in improving cellular uptake and biological activity were explored.
Article
Chemistry, Applied
Changlong Zhang, Shuangbing Deng, Liya Chen, Minfei Yang, Bobo Wang, Xiaoqing Zhang, Yang Gao, Hailong Zhang
Summary: A new coumarin and 13 known compounds were isolated from the roots of Heracleum dissectum. These compounds showed varying degrees of cytotoxic activity against hepatocellular carcinoma HepG2 cell lines.
NATURAL PRODUCT RESEARCH
(2022)
Article
Computer Science, Artificial Intelligence
Yang Gao, Xiaoyi Tao, Huibing Wang, Zeng Gang, Heng Lian
Summary: This study introduces Readizy, an interdisciplinary program utilizing artificial intelligence technology to assist reading teachers and readers with reading diagnosis. By tracking readers' facial expressions and categorizing them into seven classes, Readizy provides a unique and powerful tool for emotional changes tracking with high accuracy, contributing to affective computing and reading education.
JOURNAL OF AMBIENT INTELLIGENCE AND HUMANIZED COMPUTING
(2021)
Article
Social Sciences, Interdisciplinary
Yang Gao
Summary: This article utilizes critical ethnographic narrative and language socialization theory to analyze a language teacher's life experience, finding that the development of transnational teacher identities requires translanguaging, transcultural, and transnational capitals, with critical thinking and intellectual agency serving as stimuli to sustain identity development. The article contributes to the existing literature by presenting a conceptual framework for studying language teacher identities.
Article
Nanoscience & Nanotechnology
Qinghui Qu, Yang Gao, Yayu Huo, Changlong Zhang, Jing Yang, Hailong Zhang, Qingzhi Long
Summary: This study aimed to analyze the chemical components of Rosa davurica fruits and evaluate their antihyperglycemic effect. Twenty-seven compounds were isolated and identified, with ursolic acid being the main active compound. However, the triterpenoids from the fruits showed cytotoxicity.
APPLIED NANOSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yizeng Fan, Tao Hou, Weichao Dan, Yasheng Zhu, Bo Liu, Yi Wei, Zixi Wang, Yang Gao, Jin Zeng, Lei Li
Summary: The gene encoding SPOP is frequently mutated in prostate cancer (PCa). This study reveals that SPOP functions as a tumor suppressor by degrading PrLZ, a prostate-specific and androgen-responsive gene. ERK1/2 regulates SPOP-mediated PrLZ degradation through phosphorylation, while IL-6 acts as an upstream regulator of PrLZ degradation by promoting its phosphorylation.
CELL DEATH AND DIFFERENTIATION
(2022)
Correction
Oncology
Bo Kou, Yang Gao, Chong Du, Qi Shi, Shan Xu, Chen-Qing Wang, Xinyang Wang, Dalin He, Peng Guo
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Psychology, Multidisciplinary
Yang Gao, Gang Zeng, Yongliang Wang, Amir Aziz Khan, Xiaochen Wang
Summary: This study investigates the educational planning and changes in teachers' beliefs and practices during the COVID-19 pandemic in science and technology universities. The findings show that educational planning and policies have helped teachers adapt to new demands and changes, and there is generally alignment between teachers' beliefs and practices and the educational planning. However, tensions still exist. The discussion focuses on emergency remote teaching and planning, tensions between teacher beliefs and practices, and the transition from emergency remote teaching to regular, sustainable online schooling.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Cell Biology
Xin Wang, Lei Lei, Yanhong Su, Jun Liu, Ning Yuan, Yang Gao, Xiaofeng Yang, Chenming Sun, Bin Ning, Baojun Zhang
Summary: The study reveals a novel mechanism of Pbrm1 controlling the peripheral size of iNKT cells through regulating their development and differentiation, rather than affecting their proliferation and survival.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Psychology, Multidisciplinary
Yang Gao, Lili Qin, Qiyi Gu
Summary: This mixed-method study examined the relationship among teacher beliefs, agency, and resilience during the pandemic. The findings revealed that language teachers faced emotional, physical, mentoring, and support challenges in emergency remote teaching and adopted strategies to handle these challenges. The study also proposed a theoretical framework for studying language teacher beliefs, agency, and resilience based on sociocultural theory and discussed implications for language teacher education programs.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Engineering, Mechanical
Xing Zhang, Yang Gao, Zhuocheng Guo, Wei Zhang, Jia Yin, Wanhua Zhao
Summary: A physical model-based tool wear and breakage monitoring method is proposed in this paper. The comprehensive feature is extracted from the seven-channel specific cutting force coefficients (SCFCs) through the measurements of milling force, spindle box vibration and driving current for tool wear monitoring. An efficient tool breakage monitoring method is also put forward. The verification results indicate that the proposed method can accurately estimate the cutting status of the tool and provide a research basis for the potential industrial application of tool wear and breakage monitoring technology.
MECHANICAL SYSTEMS AND SIGNAL PROCESSING
(2023)
Article
Education & Educational Research
Yang Gao, Xiaochen Wang
Summary: This study examines the effect of teacher mentoring and learner beliefs about written corrective feedback on learner revision practices in the context of peer review. The findings suggest that students believe empathy and resonance are the primary advantages of peer feedback, and teacher mentoring helps them understand and perform review and revision tasks. The student revision process includes evaluation, argumentation, correction, and polishing.
JOURNAL OF LANGUAGE AND EDUCATION
(2022)
Article
Green & Sustainable Science & Technology
Qikai Wang, Fei Sun, Xiaochen Wang, Yang Gao
Summary: UN's 2030 Agenda for Sustainable Development emphasizes the important role of education in securing a promising future in today's digital era. However, the prevalence of smartphones has led to increased digital multitasking among students, posing a significant threat to education, especially in higher education. This study surveyed 519 students from a university in China to investigate the extent of digital multitasking, motivations behind it, and beliefs about reducing phone use. The findings suggest that although students express a desire to reduce digital multitasking, they are hesitant to follow strict rules on phone use. There is also no clear consensus on whether schools should implement more restrictions.
Article
Psychology, Multidisciplinary
Yang Gao, Xiaochen Wang, Pinwei Fan
Summary: This paper explores how motivational dynamics co-evolve with academic affordances for male English majors in higher educational institutions, using complex dynamic systems theory as a theoretical stance. The study finds that male students' motivation is complex, dynamic, and non-linear, influenced by various factors. The study also offers insights and suggestions for language lecturers and universities to improve inclusivity and equality of opportunity for male students in English major programs.
CURRENT PSYCHOLOGY
(2023)
Proceedings Paper
Engineering, Electrical & Electronic
Xiaopeng Zhang, Xueyong Wei, Yang Gao, Minghui Zhao, Yonghong Qi, Libo Zhao, Zhuangde Jiang
Summary: This paper introduces a tunable quasi-zero stiffness mechanism for a MEMS gravimeter, utilizing a combination of pre-shaped bistable beam and conventional folded springs. V-beam actuators are employed for stiffness compensation. The system's behavior is theoretically modeled using the Galerkin method, demonstrating potential for a highly stable gravimeter through active tuning of negative stiffness values and intervals.
2021 IEEE 16TH INTERNATIONAL CONFERENCE ON NANO/MICRO ENGINEERED AND MOLECULAR SYSTEMS (NEMS)
(2021)
Article
Education & Educational Research
Yang Gao
Summary: This paper uses sociocultural theory and autoethnography to explore how transnational experiences and higher education policies shape the identities and mobility of transnational intellectuals. It suggests that transnational identity development can be used as an analytical tool for advocating social justice and developing international education programs. The paper also proposes a conceptual framework for studying transnational identities and mobility.
HIGHER EDUCATION POLICY
(2021)
