Article
Nanoscience & Nanotechnology
Ming Lin, Mengdi Lu, Yuzhang Liang, Li Yu, Wei Peng
Summary: Localized surface plasmon resonance (LSPR) and lossy mode resonance (LMR) are simultaneously excited by gold nanoparticle (AuNP) arrays and top-coated polyelectrolyte layer on optical fibers, enhancing the sensitivity of the optical sensor. Thicker polyelectrolyte layer leads to higher refractive index sensitivity, and the optimized sensor with 50 nm AuNPs and 20 PAH/PSS bilayers shows improved stability and sensitivity.
ACS APPLIED NANO MATERIALS
(2022)
Article
Engineering, Electrical & Electronic
Yumei Zhang, Liyun Ding, Jue Zhao, Xingdong Jiang, Fei Ma
Summary: Acetylcholine is an important neurotransmitter that can be detected using a simple electrostatic interaction to create an optical fiber biosensor. The biosensor has high sensitivity and a linear range, making it more convenient, simple, and cost-effective compared to traditional detection methods.
IEEE SENSORS JOURNAL
(2023)
Article
Biophysics
Lu He, Fan He, Yanting Feng, Xu Wang, Yongxin Li, Yonghui Tian, Aihua Gao, Pei Zhang, Xinyuan Qi, Zewei Luo, Yixiang Duan
Summary: The study introduces a novel approach to develop a highly sensitive cytosensor for cancer diagnosis, integrating localized surface plasma resonance (LSPR) with plasmonic photothermal treatment (PPT), showing great potential in clinical application.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Engineering, Electrical & Electronic
Santosh Kumar, Zhu Guo, Ragini Singh, Qinglin Wang, Bingyuan Zhang, Shuang Cheng, Feng-Zhen Liu, Carlos Marques, Brajesh Kumar Kaushik, Rajan Jha
Summary: This study introduces a fiber-optic localized surface plasmon resonance (LSPR) based biosensor for sensitive detection of Shigella bacterial species. By controlled etching and coating with nanomaterials, the sensor achieves increased refractive index sensitivity and excitation of localized plasmons. Results show successful and efficient detection of Shigella with high sensitivity, making it potentially valuable in the future as an alternative to existing commercial methods.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2021)
Article
Engineering, Electrical & Electronic
Hsueh-Tao Chou, Yong-Sen Liao, Tien-Ming Wu, Shih-Han Wang, Kuan-Hua Chiang, Wei-Chao Su
Summary: This study presents the development of a localized surface plasmon resonance (LSPR) based optical fiber biosensor. The sensitivity of the sensor is improved by modifying the surface of fiber probes with gold nanoparticles (AuNPs) and graphene oxide (GO) to form a nanocomposite film. The immobilized fiber probes exhibit quicker reaction and larger resonant wavelength shift compared to the AuNPs fiber probe. In addition, the GO/AuNPs fiber probe shows better sensitivity, linearity, and a lower limit of detection in a low concentration of mouse IgG detection.
IEEE SENSORS JOURNAL
(2022)
Article
Engineering, Electrical & Electronic
Ajay Kumar Agrawal, Akanksha Ninawe, Anuj Dhawan
Summary: This paper reports a significantly improved sensing response of a plasmonic sensor based on a nanopillar array separated from a thin film, operated using the Kretschmann configuration. The sensor shows high sensitivity and figure of merit for both localized and bulk sensing responses. It can be easily fabricated and has great potential for biosensing applications.
IEEE SENSORS JOURNAL
(2022)
Article
Nanoscience & Nanotechnology
Prachi R. Yadav, Mehedi H. Rizvi, Bjoern Kuttich, Sumeet R. Mishra, Brian S. Chapman, Brian B. Lynch, Tobias Kraus, Amy L. Oldenburg, Joseph B. Tracy
Summary: The organization of plasmonic nanoparticles in shape-memory polymer films was studied for their coupling strength and polarization dependence. Significant polarization-dependent response was observed during stretching, which disappeared after shape recovery. The study also demonstrated the potential application of these materials as optical thermal history sensors.
ACS APPLIED NANO MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Angeline S. Dileseigres, Yoann Prado, Olivier Pluchery
Summary: The functionalization of gold nanoparticles with thiol molecules in solution is crucial for their application development. In this study, the changes in localized surface plasmon resonance (LSPR) peak due to the reaction between thiol molecules and gold nanoparticles were investigated using UV-visible spectroscopy. The saturation of thiol molecules on the nanoparticle surface was confirmed, and the wavelength shift was accurately predicted using an analytical model. The kinetics of the functionalization reaction were found to be rapid, completing in less than an hour.
Article
Chemistry, Multidisciplinary
Mengdi Lu, Wei Peng, Ming Lin, Fang Wang, Yang Zhang
Summary: A self-assembled templating technique using block copolymer layer was proposed for LSPR sensors, resulting in a high uniformity and density of gold nanoparticle monolayer. The performance in LSPR resonance wavelength and refractive index sensitivity significantly improved compared to conventional techniques, with a notable decrease in detection limit.
Article
Materials Science, Multidisciplinary
Jingwei Lv, Haihao Fu, Chunjie Hu, Zao Yi, Lin Yang, Yanshu Zeng, Paul K. Chu, Chao Liu
Summary: This paper designs a double-formant SPR refractive index sensor, which combines anti-resonant fiber and gold filling material to achieve high sensitivity and wide detection range, suitable for biochemical detection and geological exploration.
RESULTS IN PHYSICS
(2022)
Article
Optics
Xiang Wang, Rinze Benedictus, Roger M. Groves
Summary: In this paper, the spectral peak shift of an optical fiber containing gold nanoparticles under axial strain was analyzed. The research showed that strain could induce peak wavelength shift by nanoparticles, which has the potential to be tuned for highly sensitive strain sensing.
OPTICS AND LASER TECHNOLOGY
(2022)
Article
Chemistry, Analytical
Hyeong-Min Kim, Hyo-Jun Kim, Jae-Hyoung Park, Seung-Ki Lee
Summary: This study combines sandwich immunoassay with fiber-optic localized surface plasmon resonance (FO LSPR) for real-time and high-sensitivity analysis of low-concentration targets. By using second antibody-second gold nanoparticle conjugates, the detection limit is significantly enhanced and has good selectivity. The practical applicability of this method in detecting patient serum is confirmed and compared with a commercial assay kit.
ANALYTICA CHIMICA ACTA
(2022)
Review
Chemistry, Analytical
Seunghun Lee, Hyerin Song, Heesang Ahn, Seungchul Kim, Jong-ryul Choi, Kyujung Kim
Summary: This article discusses the latest research methods and experimental results of fiber-optic LSPR sensors, confirming their potential applications in the fields of chemistry, physics, and biology with the ability to achieve high sensitivity target measurements.
Article
Engineering, Multidisciplinary
Zi-Han Ren, Qi Wang, Xue-Wei Cong, Wan -Ming Zhao, Jing-Ren Tang, Lei Wang, Xin Yan, Ai -Song Zhu, Feng-Mei Qiu, Bin -Hai Chen, Ke-Ke Zhang
Summary: In this study, a core mismatch SPR sensor with tapered and U-shaped structure was proposed to improve the low sensitivity and broad spectrum of traditional fiber sensors. The introduction of single-mode fiber and tapered structure increased the resonance valley depth and narrowed the full width at half maxima.
Article
Chemistry, Analytical
Yichao Xu, Meng Xiong, Hui Yan
Summary: A low-cost, portable, and reusable optical fiber-based LSPR biosensor for detecting ZEN was developed in this study, showing good sensitivity, selectivity, and potential for on-site ZEN monitoring.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Biochemical Research Methods
Loan Thi Ngo, Wei-Kai Wang, Yen-Ta Tseng, Ting-Chou Chang, Pao-Lin Kuo, Lai-Kwan Chau, Tze-Ta Huang
Summary: A new biosensing method utilizing MutS protein and fiber optic particle plasmon resonance (FOPPR) sensing system has been developed to detect gene mutations with high sensitivity (limit of detection down to 0.49 nM) and short analysis time (as short as 15 min). Validation using patient samples has shown accurate determination of allelic fraction, making this method a promising tool for detecting single nucleotide polymorphisms in biological samples at point-of-care sites.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Engineering, Electrical & Electronic
Tuan Vu Quoc, Viet Nguyen Ngoc, Bao-Anh Hoang, Chun-Ping Jen, Trinh Chu Duc, Tung Thanh Bui
Summary: Development of compact and low-cost electronic circuits is crucial in the biosensor field. This study presents the design and development of an electrical impedance measurement circuit board for protein pre-concentration and detection microfluidic chips. The proposed design effectively eliminates noise signals and enables a potential method for point-of-care diagnostic applications.
IETE JOURNAL OF RESEARCH
(2023)
Review
Chemistry, Multidisciplinary
Johny James, A. Raja Annamalai, A. Muthuchamy, Chun-Ping Jen
Summary: There is a growing demand for low-weight high strength materials in automotive, space aerospace, and structural industries in the current engineering world. Metal matrix composites are widely used in these industries due to their excellent properties, with particle reinforcement playing a crucial role. Among various metal matrices, aluminum stands out for its cost-effective and abundant availability.
Review
Crystallography
Muthe Srikanth, A. Raja Annamalai, A. Muthuchamy, Chun-Ping Jen
Summary: Refractory high-entropy alloys (RHEAs) are unique due to their high-temperature strength, oxidation resistance, and corrosion resistance, potentially replacing Ni-based superalloys. Various manufacturing processes and alloying elements affect the properties of RHEAs.
Article
Engineering, Biomedical
Hien Vu-Dinh, Loc Do Quang, Ching Chun Chang, Cuong Nguyen Nhu, Hang Tran Thanh, Tung Thanh Bui, Trinh Chu Duc, Chun-Ping Jen
Summary: The study proposed a biomicrofluidic platform for specifically isolating human lung carcinoma A549 cells in microfluidic channels, based on the effect of the magnetic field on aptamer-conjugated magnetic beads. Results showed that the system could efficiently capture over 70% of lung carcinoma cells within 15 minutes at a flow rate of 5 µL/s.
BIOMEDICAL MICRODEVICES
(2021)
Article
Chemistry, Physical
A. Raja Annamalai, A. Muthuchamy, Muthe Srikanth, Senthilnathan Natarajan, Shashank Acharya, Anup Khisti, Chun-Ping Jen
Summary: The addition of molybdenum to the W-Ni-Fe alloy significantly affects its material properties, with the 45W-45Mo alloy showing the smallest grain size and highest mechanical strength, while the 67.5Mo alloy exhibits the highest hardness.
Review
Chemistry, Multidisciplinary
Renu Kiran Shastri, Chinmaya Prasad Mohanty, Sitaram Dash, Karthick Muthaiah Palaniappan Gopal, A. Raja Annamalai, Chun-Ping Jen
Summary: This paper examines the effects of various association techniques in electrical discharge machining (EDM) and evaluates their impact on performance measures. The study contributes to improving the performance of EDM machining and proposing new solutions.
Article
Engineering, Chemical
Shi-Wen Chen, Tran Thi Anh Hong, Chun-Tung Chiang, Lai-Kwan Chau, Chun-Jen Huang
Summary: Organosilanes have been widely used in sol-gel material synthesis, surface functionalization, and nanotechnology. However, the limitations of organosilane have led to the emerging interest in silatrane, which offers unique tricyclic caged structure and chemical stability. This study demonstrated the application of silatrane in modifying silicon oxide substrates, achieving thin and uniform coatings. The functionalization of silatrane with polymers and immobilization of gold nanoparticles were also successfully achieved. The results showed superior protein repellency of MPS-PEGMA films compared to MPTMS-PEGMA films, and the cluster size of gold nanoparticles on APS films increased significantly after acid treatment.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2022)
Review
Chemistry, Multidisciplinary
M. Somasundaram, Narendra Kumar Uttamchand, A. Raja Annamalai, Chun-Ping Jen
Summary: This review paper focuses on the microstructural, mechanical, biological, and corrosion resistance properties of spark plasma sintered magnesium (Mg) composites. Various researchers have optimized the composition, processing techniques, and surface modifications to overcome the issue of oxidation. The reinforcement material affects the mechanical properties and corrosion resistance of Mg composites. Further research is needed on the impact of process parameters on the quality of Mg composites.
Article
Chemistry, Analytical
Han-Long Liu, Yen-Ta Tseng, Mei-Chu Lai, Lai-Kwan Chau
Summary: In this study, a fiber optic nanogold-linked immunosorbent assay (FONLISA) method was developed for the rapid, sensitive, and low-cost detection of the important blood biomarker for heart failure, N-terminal pro-brain natriuretic peptide (NT-proBNP). The method utilizes a sandwich immunoassay approach and detects the analyte through changes in light intensity caused by AuNPs on the fiber core surface. The method exhibits a wide dynamic range and a low limit of detection, and shows good correlation with a commercial laboratory-based method. This method has the potential to be used as a point-of-care testing tool.
Article
Chemistry, Analytical
Ting-Chou Chang, Aileen Y. Sun, Yu-Chung Huang, Chih-Hui Wang, Shau-Chun Wang, Lai-Kwan Chau
Summary: The global pandemic of COVID-19 has driven the demand for sensitive and rapid point-of-care testing methods. This study introduces a fiber optic particle plasmon resonance biosensor that utilizes a single-stranded DNA aptamer to detect the SARS-CoV-2 nucleocapsid protein with a 15-minute detection time and a limit of detection of 2.8 nM.
Article
Chemistry, Analytical
Yuan-Yu Chen, Chih-Lu Wu, Chia-Wei Hsu, Chih-Hui Wang, Chung-Rui Su, Chun-Jen Huang, Hau-Ren Chen, Lai-Kwan Chau, Shau-Chun Wang
Summary: A fast and label-free fiber optic particle plasmon resonance (FOPPR) immunosensing method was developed to detect nervous necrosis virus (NNV) in high-value economic aquatic species. With an enhancement method, it showed high sensitivity and potential as an outbreak surveillance tool.
Article
Chemistry, Physical
Venkatachalam Gopalan, Mugatha Surya Vardhan, Vishal Thakur, Annamalai Krishnamoorthy, Vignesh Pragasam, Mallikarjuna Reddy Degalahal, Pitchumani Shenbaga Velu, A. Raja Annamalai, Chun-Ping Jen
Summary: Scientists are interested in new green composites as they may possess comparable qualities to synthetic fiber composites, addressing concerns about environmental contamination. This study explores the potential for using the produced green composite in various load-bearing structural applications involving buckling. Investigating the buckling characteristics of the composite is crucial to understanding its structural stability and the potential for instability caused by buckling. Numerical examination of the buckling properties of composite specimens, using epoxy as the matrix and chemically treated cellulose microfibrils as reinforcements, is conducted under axial compressive stress. The numerical model is created using the finite element method and validated through ANSYS software by comparing critical buckling loads determined through research for three samples. The numerical findings are then compared with results derived from the ANOVA regression equation. This study also investigates the utilization of the green composite in various load-bearing structural applications involving buckling. Due to the green composite's comparable buckling properties to synthetic composites, it has the potential to replace numerous synthetic composites, thus enhancing environmental sustainability.
Review
Medicine, General & Internal
Somit Jain, Dharmik Naicker, Ritu Raj, Vedanshu Patel, Yuh-Chung Hu, Kathiravan Srinivasan, Chun-Ping Jen
Summary: Cancer is a dangerous disease that can have negative consequences for the body, is a leading cause of death, and is difficult to detect. Doctors use different methods, including imaging tests, to diagnose cancer. This article evaluates computational-intelligence approaches in cancer diagnosis using machine learning and deep learning models, and explores their advantages and disadvantages. Despite some clinical issues, artificial intelligence has significant potential to enhance cancer imaging and diagnosis.
Proceedings Paper
Engineering, Electrical & Electronic
Hang Tran Thanh, Loc Do Quang, Bao-Anh Hoang, Tung Thanh Bui, Trinh Chu Duc, Chun-Ping Jen
Summary: This study efficiently isolated human lung carcinoma cell line A549 using the proposed SMAC platform. Experimental results showed a capture rate of above 70% for the targeted cells within 15 minutes, with a lower capture rate for non-target cells. The platform demonstrated high selectivity, portability, and simplicity, making it suitable for point-of-care applications in biological and clinical settings.
2021 21ST INTERNATIONAL CONFERENCE ON SOLID-STATE SENSORS, ACTUATORS AND MICROSYSTEMS (TRANSDUCERS)
(2021)
