Article
Multidisciplinary Sciences
Meiwand Bedar, Tiam M. Saffari, Patricia F. Friedrich, Guilherme Giusti, Allen T. Bishop, Alexander Y. Shin
Summary: This article discusses the focus of research in nerve regeneration and the experimental methods used to assess functional recovery in a rat sciatic nerve model. The technique of isometric force measurement of tetanic muscle contraction is crucial for evaluating motor recovery after nerve injury or repair.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Multidisciplinary Sciences
Brent J. Raiteri, Leon Lauret, Daniel Hahn
Summary: This study aimed to estimate the force-length relation of the tibialis anterior (TA) muscle. The results showed that TA produced its maximum active force at 15° dorsiflexion, and its force-length curve agreed with a sarcomere model within the muscle. These findings are important for predicting forces during movement.
Article
Nutrition & Dietetics
David B. Copithorne, Kalter Hali, Charles L. Rice
Summary: This study compared the effects of proximal and distal blood flow occlusion on motor unit firing rates during low-intensity fatiguing tasks. Proximal occlusion resulted in the greatest fatigue and reduction in motor unit rates, while distal occlusion induced more fatigue and rate reduction compared to a control task.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2021)
Article
Clinical Neurology
Masahiro Sonoo, Haruo Uesugi, Go Ogawa, Keiichi Hokkoku, Takamichi Kanbayashi, Mana Higashihara, Stefan Stalberg, Erik Stalberg
Summary: The study re-evaluated the clustering index method (CI method) for single-channel surface electromyography with an expanded patient data set. The optimal window width of 22.5 ms was identified, achieving high sensitivity and specificity for diagnosing neurogenic and myogenic disorders.
Article
Physiology
Matjaz Divjak, Gasper Sedej, Nina Murks, Mitja Gerzevic, Uros Marusic, Rado Pisot, Bostjan Simunic, Ales Holobar
Summary: This study examined the activation patterns and coactivation changes in different muscles of older and young participants before and after bed rest. The results showed that older individuals had higher muscle discharge rates in the gastrocnemius compared to the young, regardless of the contraction level. However, the differences were less consistent in the tibialis anterior and soleus muscles. Individual adaptations to aging or bed rest also influenced the results.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Clinical Neurology
Joao Aris Kouyoumdjian, Carla Renata Graca
Summary: The study calculates the reference values for jitter parameters in commonly tested muscles using a disposable concentric needle. It measures the jitter in the Tibialis Anterior muscle, which is not routinely tested, and provides reference ranges for the mean consecutive difference. This study provides guidance for measuring muscle jitter.
FRONTIERS IN NEUROLOGY
(2022)
Article
Sport Sciences
Eirini Tsatsaki, Ioannis G. Amiridis, Ales Holobar, Georgios Trypidakis, Fotini Arabatzi, Eleftherios Kellis, Roger M. Enoka
Summary: The study aimed to evaluate the impact of muscle length on dorsiflexor force steadiness and motor unit discharge characteristics during submaximal contractions. Results showed that muscle length affected force steadiness and the average discharge rate of motor units varied at different ankle angles.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2022)
Article
Multidisciplinary Sciences
Samuel T. Kwak, Young-Hui Chang
Summary: Humans can adapt their gait pattern to minimize the metabolic cost of walking within a few steps, which is faster than any direct physiological sensor. Walking economy can be sensed indirectly through mechanoreceptors that correlate with the metabolic cost. Our study found that velocity feedback from the tibialis anterior muscle during early stance phase of walking can indirectly sense walking economy. This provides a biomechanical framework for understanding the neural mechanisms behind the rapid optimization of walking economy.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Carlos Sepulveda, Juan Manuel Rodriguez, Matias Monsalves-Alvarez, Camila Donoso-Barraza, Francisco de la Fuente, Isabelle Matias, Thierry Leste-Lasserre, Philippe Zizzari, Eugenia Morselli, Daniela Cota, Miguel Llanos, Rodrigo Troncoso
Summary: The endocannabinoid system (ECS) regulates energy metabolism and is involved in the pathogenesis of metabolic diseases. Autophagy is associated with various cellular processes and its deregulation is linked to diseases. This study found that the CB1 receptor controls autophagy in the skeletal muscle of both lean and obese mice.
BIOLOGICAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
J. Cortney Bradford, Andrew Tweedell, Logan Leahy
Summary: Valid approaches for interfacing with and deciphering neural commands related to movement are crucial for understanding muscular coordination and developing prostheses and wearable robotics. This report presents a dataset consisting of simultaneous recordings of high density surface EMG, intramuscular EMG, and joint dynamics during static and dynamic muscle contractions. The data can be used for validating methods for extracting neural signals, developing torque output prediction models, or creating movement intent classifiers.
Article
Biochemistry & Molecular Biology
Magally Ramirez-Ramirez, Francisca Fernandez-Valverde, Andrea Resendiz-Garcia, Mirna G. Martinez-Damas, Luis Javier Cano-Martinez, Alejandro Zentella-Dehesa, Ramon M. Coral-Vazquez
Summary: Several studies have shown the beneficial effects of Epicatechin (Epi) on skeletal muscle in murine models, muscular dystrophy patients, diabetic patients, and murine sarcopenia models. Epi enhances antioxidant pathways, improves muscle architecture, and accelerates skeletal muscle repair after chemically induced damage. The study found that Epi significantly reduced damage area and hypertrophy in the Tibialis anterior muscle of mice with BaCl2-induced damage. In addition, Epi increased the expression of beta-catenin (active) and myogenic proteins such as MyoD and Myogenin.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Anatomy & Morphology
Piotr Karauda, Michal Podgorski, Friedrich Paulsen, Michal Polguj, Lukasz Olewnik
Summary: The study examined the insertion of the tibialis anterior tendon in human fetuses and classified it into five types. The most common type was found to be Type V, characterized by a single tendon inserting onto the medial cuneiform bone. The study also revealed high variability in tendon insertion patterns among fetuses, with Type V being the most frequent.
Review
Medicine, General & Internal
Nicol Zielinska, Richard Shane Tubbs, Friedrich Paulsen, Bartlomiej Szewczyk, Michal Podgorski, Andrzej Borowski, Lukasz Olewnik
Summary: This review provides condensed information about the tibialis anterior tendon, including its origin, attachment, and comparison of different classification systems.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Engineering, Biomedical
S. G. Bodkin, J. T. Pethick, E. A. Dooley, S. D. Russell, J. M. Hart
Summary: This study aimed to compare quadriceps torque complexity in anterior cruciate ligament reconstructed patients to healthy controls and assess the relationships between torque complexity and patient outcomes. The findings showed that anterior cruciate ligament reconstructed patients had lower quadriceps torque complexity compared to healthy controls, and torque complexity was weakly negatively correlated with quadriceps strength, subjective function, and fatigue resistance of the quadriceps.
CLINICAL BIOMECHANICS
(2023)
Article
Clinical Neurology
Chiara Berteotti, Viviana Lo Martire, Sara Alvente, Stefano Bastianini, Gabriele Matteoli, Hiroshi Ohtsu, Jian-Sheng Lin, Alessandro Silvani, Giovanna Zoccoli
Summary: This study found that the occurrence rate of tibialis anterior electromyogram bursts during sleep was significantly lower in mice with histamine deficiency compared to wild-type mice. The data suggest that limb movements during sleep may depend on the integrity of brain histamine signaling.
JOURNAL OF SLEEP RESEARCH
(2021)
Article
Surgery
Femke Mathot, Nadia Rbia, Allen T. Bishop, Steven E. R. Hovius, Alexander Y. Shin
Article
Biotechnology & Applied Microbiology
Tiam M. Saffari, Katelyn Chan, Sara Saffari, Kevin J. Zuo, Renee M. McGovern, Joel M. Reid, Gregory H. Borschel, Alexander Y. Shin
Summary: The study explored the potential of using tacrolimus and mesenchymal stem cells combined with a fibrin gel-based drug delivery system to enhance peripheral nerve regeneration. The results showed that the combined delivery method did not result in cytotoxic effects and could be beneficial for promoting peripheral nerve regeneration.
BIOTECHNOLOGY AND BIOENGINEERING
(2021)
Article
Biotechnology & Applied Microbiology
Sara Saffari, Tiam M. Saffari, Katelyn Chan, Gregory H. Borschel, Alexander Y. Shin
Summary: The study investigated the combined effect of mesenchymal stem cells (MSC) and local delivery of tacrolimus (FK506) on nerve regeneration in nerve autografts and decellularized allografts. Results showed that either MSC or FK506 treatment alone improved neurite outgrowth, and their combination further enhanced neurite extension in both types of grafts.
BIOTECHNOLOGY AND BIOENGINEERING
(2021)
Review
Orthopedics
Alexander Y. Shin, Mariano Socolovsky, Ketan Desai, Michael Fox, Shufeng Wang, Robert J. Spinner
Summary: This expert opinion study examined regional differences in adult traumatic pan brachial plexus injuries, including demographics, injury mechanisms, patient evaluation, and treatment strategies. Variations in reconstructive surgery were identified across regions/surgeons, highlighting the need for future studies to accurately compare outcomes in different regions.
JOURNAL OF HAND SURGERY-EUROPEAN VOLUME
(2022)
Article
Orthopedics
Derek B. Asserson, Taylor J. North, Peter C. Rhee, Allen T. Bishop, Jeffrey S. Brault, Alexander Y. Shin
Summary: A retrospective review compared ultrasound guided thread carpal tunnel release (TCTR) and open carpal tunnel release (OCTR) in hospital employees and found that TCTR resulted in a quicker return to work compared to OCTR. Regardless of the surgical technique, all patients experienced symptom resolution without any complications.
JOURNAL OF HAND SURGERY-EUROPEAN VOLUME
(2022)
Review
Orthopedics
Anthony J. Archual, Allen T. Bishop, Alexander Y. Shin
Summary: Vascularized bone grafts have shown superior outcomes compared to nonvascularized grafts in challenging clinical situations. Pedicled grafts from the distal radius, medial femoral condyle, ribs, and fibula, as well as free grafts from the fibula and medial femoral condyle/trochlea, have demonstrated particular usefulness and versatility.
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
(2022)
Article
Orthopedics
Christina M. Webber, Jason S. Egginton, Alexander Y. Shin, Kenton R. Kaufman
Summary: The study explored patient perspectives on using an MEO after surgical treatment for traumatic BPI. Patients showed a positive attitude towards using an MEO as a rehabilitation tool, and desired a more streamlined and stronger device. Continued patient engagement in evaluating and developing medical devices and treatment plans can lead to improved outcomes that are important to patients.
PROSTHETICS AND ORTHOTICS INTERNATIONAL
(2021)
Article
Orthopedics
Joshua J. Meaike, Christian Athens, Nicole Sgromolo, Alexander Y. Shin, Peter C. Rhee
Summary: The study found that there is no increased risk of wound healing complications with the use of multiple skin incisions (>= 2) in the surgical management of distal radius fractures. Surgeons should have the confidence to utilize the necessary number of skin incisions to effectively reconstruct distal radius fractures.
JOURNAL OF WRIST SURGERY
(2022)
Article
Orthopedics
John J. Bartoletta, Dana Rioux-Forker, Raahil S. Patel, Katharine M. Hinchcliff, Alexander Y. Shin, Peter C. Rhee
Summary: The study found that concomitant PRC might not improve union rates or reduce complications in patients undergoing TWA.
JOURNAL OF WRIST SURGERY
(2022)
Article
Orthopedics
Sean R. Cantwell, Andrew W. Nelson, Brandon P. Sampson, Robert J. Spinner, Allen T. Bishop, Nicholas Pulos, Alexander Y. Shin
Summary: Selective amputation is an effective treatment for BPI patients in whom surgical reconstruction fails. It can reduce pain, increase employment rates, and result in high satisfaction. MEPs allow for terminal grasp/release in amputees with sufficient signal and are associated with high rates of prosthesis use.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2022)
Review
Orthopedics
Alexander Y. Shin, Allen T. Bishop, Michelle F. Loosbroch, Robert J. Spinner
Summary: A multidisciplinary brachial plexus clinic is a new approach to treating brachial plexus injuries that involves collaboration between different surgical specialties. This review provides a detailed account of the history, philosophy of care, development/implementation, and impact of a multidisciplinary brachial plexus team at the Mayo Clinic.
JOURNAL OF HAND SURGERY-EUROPEAN VOLUME
(2022)
Article
Rehabilitation
James B. Meiling, John H. Hollman, Alexander Y. Shin, Jeffrey S. Brault
Summary: This study demonstrates that the ultrasound-measured interstructural safe zone distance was significantly greater in the ulnarly deviated position than in either the neutral position or radially deviated position. These findings may have important implications for improving the safety of ultrasound-guided injections.
Article
Orthopedics
Sandesh G. Bhat, Emily J. Miller, Alexander Y. Shin, Kenton R. Kaufman
Summary: This study compared the neuromuscular control of elbow flexors in unimpaired control subjects and patients with traumatic brachial plexus injury who underwent nerve transfer surgery. The results showed significant differences in neuromuscular control and torque generation between the two groups. The control group exhibited better modulation of myoelectric activation and achieved greater variability in neuromuscular control with varying torque demand, while the nerve transfer group could not modulate their myoelectric activation effectively. Further research on improving neuromuscular control is necessary for optimizing functional outcomes in nerve injury patients.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Sara Saffari, Daan J. Rademakers, Nicholas Pulos, Alexander Y. Shin
Summary: Modulating the nerve's microenvironment using exosomes can enhance nerve regeneration. This study aimed to determine the optimal dose of purified exosome product (PEP) for maximal neurite extension. Treatment with 5% PEP resulted in the longest neurite extension and was superior to the untreated control, while treatment with higher concentrations showed no significant difference. Live cell imaging suggested that PEP migrated towards the neural regeneration site. Overall, 5% PEP was found to be the optimal concentration for nerve regeneration based on this in vitro dose-response analysis.
BIOTECHNOLOGY AND BIOENGINEERING
(2023)
Article
Orthopedics
J. J. Meaike, J. D. Meaike, M. S. Collins, A. T. Bishop, A. Y. Shin
Summary: The study compared preoperative MRI findings with intraoperative bleeding in the proximal scaphoid. The results showed that MRI was not reliable in assessing the vascularity of the proximal fragment compared to intraoperative assessment. Future efforts should focus on developing objective measures of osseous blood flow that can be performed during surgery.
BONE & JOINT JOURNAL
(2023)
