Journal
MICROSCOPY AND MICROANALYSIS
Volume 19, Issue 4, Pages 808-813Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S1431927613000597
Keywords
nanoparticle tracking analysis; tobacco mosaic virus; spherical particles; biologically active nanocomplexes
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Funding
- Federal Program Scientific and scientific-educational personnel of innovative Russia [8564]
- Russian Foundation for Basic Research [13-04-00543-a]
- M.V. Lomonosov Moscow State University Program of Development
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Nanoparticle tracking analysis (NTA) was first applied to biologically active nanocomplexes to obtain concurrent information on their size, state of aggregation, concentration, and antigenic specificity in liquid. The subject of the NTA was an immunogenic complex (a candidate nanovaccine) comprised of spherical particles (SPs) generated by thermal remodeling of the tobacco mosaic virus and Rubella virus tetraepitopes exposed on the surface of SP.
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