Journal
SCHIZOPHRENIA BULLETIN
Volume 42, Issue 4, Pages 874-880Publisher
OXFORD UNIV PRESS
DOI: 10.1093/schbul/sbv123
Keywords
schizophrenia; psychosis; self-disorders; neuroimaging; prodromal; Heidelberg mescaline study; aberrant salience; Bayesian modeling; Gruhle; Mayer-Gross; phenomenology
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Funding
- NARSAD Young Investigator Award
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Self-disorders (SDs) (from the German Ichstorungen) are alterations of the first-person perspective, long associated with schizophrenia, particularly in early phases. Although psychopathological features of SDs continue to be studied, their neurobiological underpinnings are unknown. This makes it difficult to integrate SDs into contemporary models of psychosis. The present review aims to address this issue, starting from an historical excursus revealing an interconnection between neuroscientific models and the origin of the psychopathological concept of SDs. Subsequently, the more recent neurobiological models related to SDs are discussed, particularly with respect to the onset of schizophrenia.
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