Journal
MICROPOROUS AND MESOPOROUS MATERIALS
Volume 113, Issue 1-3, Pages 445-452Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micromeso.2007.12.003
Keywords
mesoporous silicates; poorly water solubility drug; carbamazepine; dissolution rate; physical stability
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Carbamazepine is an antiepileptic drug characterized by poorly water solubility that affects negatively its bioavailability. Here we report oil the ability of the mesoporous silicate MCM-41 to act as a vehicle able to improve the drug dissolution rate by preventing drug crystallization. Carbamazepine was adsorbed into nanopores of MCM-41 and the drug, loaded MCM-41 was characterized by X-ray powder diffraction, N-2 adsorption, FT-IR spectroscopy and thermogravimetric and differential scanning calorimetry analyses. Carbamazepine loading resulted 14% and the drug was not arranged in crystalline form. In vitro drug release results showed a remarkable increase of carbamazepine dissolution rate in all the different tested media. As this improvement is due both to the high specific surface area of loaded MCM-41 and to the lack of crystalline drug, storage stability studies at different environment conditions were conducted in order to investigate the ability of MCM-41 to prevent drug crystallization. (C) 2007 Elsevier Inc. All rights reserved.
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