Journal
MICRON
Volume 40, Issue 4, Pages 480-485Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.micron.2008.12.003
Keywords
Low energy STEM; SEM; Mass-thickness contrast; Drug-encapsulating particles
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New drug-encapsulating particles were investigated using bright field (BF) scanning transmission electron Microscopy (STEM) in a field emission gun (FEG) scanning electron microscope (SEM). Thickness characterization was done based on measuring the effective cross-section for interaction in our sample-detector configuration using calibration particles. A simplified analytical model, taking account of BF-STEM contrast and effective cross-section for interaction, was utilized for transforming projected two-dimensional BF-STEM images into three-dimensional thickness images. The three-dimensional characterization is demonstrated on a new family of biological materials composed of submicron to Micron drug-free and drug-encapsulating particles. The importance of using BF-STEM in SEM, relative to other electron microscopy methods, is discussed as well as the lateral and depth resolution. (C) 2008 Elsevier Ltd. All rights reserved.
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