Article
Chemistry, Analytical
Kieu The Loan Trinh, Woo Ri Chae, Nae Yoon Lee
Summary: The early detection of pathogens is crucial for reducing fatalities and improving prognosis. Traditional laboratory tests are time-consuming and require trained personnel, limiting their prompt use. Microfluidic devices, such as paper-based analytical devices, show great potential for point-of-care testing. This review summarizes fabrication techniques and fluid controlling strategies of mu PADs, and highlights recent bacterial and viral detection strategies.
MICROCHEMICAL JOURNAL
(2022)
Review
Chemistry, Analytical
Hardik Ramesh Singhal, Anusha Prabhu, M. S. Giri Nandagopal, Thangaraju Dheivasigamani, Naresh Kumar Mani
Summary: Paper-based devices for analytical applications have attracted researchers' interest due to their portability, versatility, and ease of interpretation, despite the barrier posed by sophisticated manufacturing techniques for widespread adoption in low-cost settings. Recent efforts have been made towards developing cost-effective paper-based analytical devices, with emphasis on utilizing readily available stationaries for fabrication. Additionally, the use of various low-cost or off-the-shelf equipment for creating hydrophobic barriers, electrodes, and housing for old detection techniques on plain paper has been explored in this review.
MICROCHEMICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Sunil Walia, Ira Bhatnagar, Juewen Liu, Sushanta K. Mitra, Amit Asthana
Summary: This study describes the fabrication of paper-based microfluidic devices using a novel ink composed of bovine serum albumin (BSA) to create hydrophobic barriers. The technique achieved minimum line gap and line width, and demonstrated proof-of-concept glucose sensing. The developed method offers ease of fabrication, cost-effectiveness, and high reproducibility.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Analytical
Ryan A. Ruiz, Jorge L. Gonzalez, Miguel Vazquez-Alvarado, Nathaniel W. Martinez, Andres W. Martinez
Summary: Paper-based microfluidic devices, known as microPADs, have the potential to improve point-of-care diagnostics. A method using a portable thermal transfer printer has been introduced as a replacement for wax printing, offering low cost, convenience, and portability.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Ryan A. Ruiz, Jorge L. Gonzalez, Miguel Vazquez-Alvarado, Nathaniel W. Martinez, Andres W. Martinez
Summary: Paper-based microfluidic devices (microPADs) are an emerging analytical platform that has the potential to enhance point-of-care diagnostics. They are fabricated by patterning hydrophobic inks on paper to create hydrophilic channels and test zones, making them inexpensive and simple to manufacture. However, the discontinuation of solid ink printers has posed challenges for wax printing, the most convenient method for producing microPADs. Here, we introduce a method using a portable thermal transfer printer to fabricate microPADs, which offers comparable results to wax printing and laser printing, with the added benefits of low cost, convenience, and portability.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Kaixin Sun, Fan Xu, Jingji Liu, Yajun Zhang, Yiqiang Fan
Summary: This study proposed a method for rapidly fabricating paper-based microfluidic devices and demonstrated its application in quantitatively analyzing amino acid content in tea. The method offers advantages of fast fabrication and low cost, and shows great potential for various applications.
Review
Biotechnology & Applied Microbiology
Joseph Benjamin Holman, Zhengdi Shi, Adeola A. Fadahunsi, Chengpan Li, Weiping Ding
Summary: Since the inception of the first electrochemical devices on paper substrates, numerous advancements have been made in microfluidic paper-based electroanalytical devices (mu PEDs), including innovative hydrophobic barriers and electrode fabrication processes. These advancements have resulted in comparable performance to conventional devices, with the additional benefits of pumpless fluidic transport and component separation. This review discusses the characteristics, functionalities, fabrication approaches, and recent applications of mu PEDs in biomedicine, environment, and food and water safety, while also addressing limitations and challenges.
BIOTECHNOLOGY ADVANCES
(2023)
Article
Chemistry, Analytical
Hiroki Toda, Wataru Iwasaki, Nobutomo Morita, Taisei Motomura, Kenshin Takemura, Masaya Nagano, Yoshitaka Nakanishi, Yuta Nakashima
Summary: A thermo-responsive valve was fabricated by plasma-induced graft polymerization, allowing for control of opening and closing based on temperature. Results suggest that this valve can effectively open and close without subsequent loss of performance.
Review
Nanoscience & Nanotechnology
Zeji Hao, Hongyu Chen, Xin Shi, Wei Tan, Guorui Zhu
Summary: Paper-based microfluidic analytical devices (mu PADs) have shown great potential in analysis, particularly in the field of saliva analysis. This review discusses the fabrication methods and applications of 2D and 3D mu PADs for saliva analysis, as well as future research directions in this area.
MICROFLUIDICS AND NANOFLUIDICS
(2021)
Article
Chemistry, Multidisciplinary
Shanshan Qin, Gaozhi Ou, Biao Wang, Zheyu Li, Rui Hu, Ying Li, Yunhuang Yang
Summary: This study reports a photolithography-free method for rapid fabrication of PDMS devices. By using a laser cutter to ablate a tape, a male photoresist mold can be obtained within 5 minutes by a simple heating-step. The method offers advantages of low input, simple operation procedure, and short fabrication time.
CHINESE CHEMICAL LETTERS
(2022)
Article
Nanoscience & Nanotechnology
Iain Macleod Briongos, Zachary D. Call, Charles S. Henry, David L. Bark Jr
Summary: Small, single-layer microfluidic paper-based analytical devices (μPADs) show potential for point-of-care applications, but their flow rates have been limited. In this study, we investigate the use of laser-cut paper channels to maximize flow rate in small profile devices. Our results show that branching, laser-cut grooves can significantly improve flow rate by 59.23-73.98% compared to a single cut, and by 435% compared to paper alone. These design considerations can be applied to more complex microfluidic devices to increase flow rates and for self-pumping stand-alone channels.
MICROFLUIDICS AND NANOFLUIDICS
(2023)
Review
Chemistry, Multidisciplinary
Eka Noviana, Tugba Ozer, Cody S. Carrell, Jeremy S. Link, Catherine McMahon, Ilhoon Jang, Charles S. Henry
Summary: Microfluidic paper-based analytical devices (muPADs) have gained significant interest as a promising analytical platform in the past decade, offering unique advantages over traditional microfluidics. This comprehensive Review highlights fabrication methods, device designs, and detection strategies, as well as the growing applications of muPADs, while discussing the field's need for further advancement to realize its full potential.
Article
Chemistry, Analytical
Raviraj Thakur, Gene Y. Fridman
Summary: Rapid prototyping methods enable non-engineering users to create microfluidic devices in a fast, simple, and inexpensive way. This study developed a liquid molding technique using wet paper molds to fabricate silicone/PDMS microfluidic devices. The influence of process parameters on device yield and quality was assessed. The method offers adjustable channel cross-section shape and utilizes electrical impedance as a marker for inspecting mold quality and identifying defects without visual tools.
Article
Chemistry, Analytical
Ahmed A. Shalaby, Chia-Wen Tsao, Akihiko Ishida, Masatoshi Maeki, Manabu Tokeshi
Summary: Cancer is a leading cause of death worldwide, and early diagnosis is crucial for successful treatment. In developing countries, there is a need for low-cost, accurate, and easy to use point-of-need (PON) devices for cancer diagnosis and treatment follow-up. Paper-based analytical devices (PADs) are considered a key solution as they provide a low-cost platform for developing PON biosensors. This review discusses the various factors involved in the development of PADs for cancer biomarker detection and summarizes the advantages and disadvantages of each method.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Electrochemistry
Yuta Nakayasu, Hiroaki Kobayashi, Shusuke Katahira, Takaaki Tomai, Itaru Honma
Summary: A rapid, one-step hydrothermal electrodeposition technique is proposed in this study for the formation of MoS2 thin films on glassy carbon substrates. The MoS2 electrocatalysts fabricated using this method exhibit good activity as hydrogen evolution catalysts. This technique is expected to be widely applicable to various electrodes and other technologies.
ELECTROCHEMISTRY COMMUNICATIONS
(2022)
Article
Materials Science, Ceramics
Jui-Hsuan Tsai, Shu-Ming Hsu, I-Chun Cheng, Cheng-Che Hsu, Jian-Zhang Chen
CERAMICS INTERNATIONAL
(2019)
Article
Engineering, Environmental
Ching-Yu Wang, Cheng-Che Hsu
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2019)
Article
Physics, Applied
Ching-Yu Wang, Cheng-Che Hsu
PLASMA PROCESSES AND POLYMERS
(2020)
Article
Materials Science, Multidisciplinary
Te-En Li, Jui-Hsuan Tsai, I-Chun Cheng, Cheng-Che Hsu, Jian-Zhang Chen
Article
Materials Science, Multidisciplinary
Ching-Feng Fan, Yi-Chia Chien, Cheng-Che Hsu, I-Chun Cheng, Li-Hsien Chien, Jian-Zhang Chen
MATERIALS RESEARCH EXPRESS
(2020)
Article
Chemistry, Multidisciplinary
Jui-Hsuan Tsai, I-Chun Cheng, Cheng-Che Hsu, Jian-Zhang Chen
Article
Physics, Applied
Tzu-Ming Huang, I-Chun Cheng, Cheng-Che Hsu, Jian-Zhang Chen
JOURNAL OF APPLIED PHYSICS
(2020)
Article
Nanoscience & Nanotechnology
Ming-Yang Kan, Qiang Lyu, Yu-Hong Chu, Cheng-Che Hsu, Kuang-Lieh Lu, Li-Chiang Lin, Dun-Yen Kang
Summary: This study utilized dielectric barrier discharge plasma in solution-phase synthesis to suppress defects in MOF membranes, resulting in a pure MOF membrane with high gas selectivity. Through comprehensive solid-state characterization and molecular simulations, insights into the properties of the MOF were obtained.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Analytical
Ching-Yu Wang, Tsung-Shun Ko, Cheng-Che Hsu
Summary: This study developed a method for VOC classification using CNN, with interpretable feature maps and gradient-weighted class activation mapping to identify spectral features. By integrating with a microplasma platform, real-time VOC monitoring application was demonstrated.
ANALYTICA CHIMICA ACTA
(2021)
Article
Physics, Applied
Ching-Yu Wang, Tsung-Shun Ko, Cheng-Che Hsu
Summary: This study utilizes explainable artificial intelligence (XAI) to analyze the optical emission spectroscopy (OES) of plasma in aqueous solutions, developing a neural network model that accurately predicts solution conductivity. Through XAI methods, it was found that certain emission lines like OH, H-gamma, and H-beta are critical to the model, capturing spectral features often overlooked by humans.
PLASMA PROCESSES AND POLYMERS
(2021)
Article
Physics, Applied
Mohana Sruthi Mallela, Jui-Hsuan Tsai, Jian-Zhi Huang, Cheng-Che Hsu, Mei-Hsin Chen, Chih- Wu, Jian-Zhang Chen, I-Chun Cheng
Summary: This study demonstrates the use of atmospheric pressure plasma treatment to enhance the interface properties between the active perovskite layer and electron transport layer in flexible perovskite solar cells. By applying a scan-mode low-temperature helium dielectric barrier discharge (DBD) jet to process the TiO2 nanoparticle layers, the photoelectrical conversion efficiency of the cells is improved from 12.30% to 13.66%. This improvement is attributed to the increase of hydrophilic functional groups and the reduction of charge transfer resistance on the surface of the TiO2 nanoparticle layer.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2022)
Article
Chemistry, Physical
Peng-Kai Kao, Michael J. Solomon, Mahesh Ganesan
Summary: The study demonstrates that changing the shape of building blocks from spheres to discoids can significantly increase the elastic modulus of colloidal gels. Through modeling fractal cluster gel rheology, it is revealed that the impact of shape anisotropy on gel elasticity is due to the combined effects on the microstructure of the gel network, the anisotropy of attractive interparticle pair potentials, and the volumetric compactness of the fractal cluster.
Article
Materials Science, Ceramics
Jheng-Yun Lai, Hong-Kai Chen, Cheng-Che Hsu, Jian-Zhang Chen
Summary: LiCl-Mn(NO3)(2)center dot 4H(2)O pastes were screen-printed on a carbon cloth substrate and converted into LiMn2O4 by furnace-calcination. The LiMn2O4 electrode was then post-processed using a nitrogen atmospheric-pressure plasma jet (APPJ) to create oxygen vacancy defects. The Li-ion hybrid supercapacitors (Li-HSCs) were tested in 1-M Li2SO4 aqueous solution by cyclic voltammetry (CV) and galvanostatic charging/discharging (GCD). The results show that proper APPJ treatment optimizes the performance of Li-HSCs, while excessive treatment may cause material damage. After a 3-minute APPJ treatment at 620 degrees C, the Li-HSCs exhibited a maximum areal capacitance of 87.96 mF/cm(2) with capacitance retention of 124.8% after a 1000-cycle CV test.
CERAMICS INTERNATIONAL
(2023)
Article
Physics, Applied
Xuan-Lun Zhang, Cheng-Che Hsu
Summary: This study proposes the use of transfer-learning-based algorithms as data reduction strategies for the classification of VOCs using plasma optical emission spectroscopy. A home-made microplasma generation device (MGD) is used to generate plasma in Ar and VOCs mixtures. Spectra are acquired from ten MGDs, and the VOCs tested are methanol, ethanol, and isopropanol. Classification is done using a convolutional neural network, and explainable artificial intelligence technique is used. VOC concentrations are quantified using linear regression and an ANN. Three transfer learning-based algorithms are tested, and spectral data is grouped into source and target datasets. The results demonstrate the potential of transfer-learning-based algorithms for data reduction and classification of spectroscopic data.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2023)
Article
Materials Science, Multidisciplinary
Ching-Feng Fan, Jui-Hsuan Tsai, Ying-Chih Liao, I-Chun Cheng, Cheng-Che Hsu, Jian-Zhang Chen
ECS JOURNAL OF SOLID STATE SCIENCE AND TECHNOLOGY
(2020)
