Article
Biotechnology & Applied Microbiology
Aoba Ota, Ayaka Mochizuki, Keitaro Sou, Shinji Takeoka
Summary: This paper investigates the potential of a static mixer (SM) in liposome formulation compared to a commonly used microfluidic device (SHM). The results indicate that liposomes prepared with SM have larger particle size but better size control, while liposomes prepared with SHM have higher encapsulation efficiency. Moreover, SM demonstrates significant advantages in user-friendliness, allowing for thorough cleaning of the mixing elements and device.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Analytical
Fang Yang, Wei Zhao, Cuifang Kuang, Guiren Wang
Summary: In this study, a quasi T-channel electrokinetics-based micromixer with electrically conductive sidewalls was investigated. It was found that this micromixer configuration achieved faster mixing compared to another widely studied micromixer configuration. The effects of Re numbers, applied AC voltage and frequency, and conductivity ratio of the two fluids on mixing results were explored. The study of this micromixer could provide new insights into electrokinetic phenomena and offer new tools for sample preparation in applications requiring fast mixing.
Article
Optics
Shashi Prakash, Subrata Kumar
Summary: The article introduces different strategies for fabricating microchannels using CO2 lasers and conducts experimental studies to compare them in terms of surface quality, cross-sectional profile, and other parameters.
OPTICS AND LASER TECHNOLOGY
(2021)
Article
Mechanics
Ekta Tripathi, Promod Kumar Patowari, Sukumar Pati
Summary: In this study, the influence of the shapes of passive micromixers on the mixing efficiency of fluids in microfluidic devices such as Lab on a chip and mu-total analysis systems was investigated. The mixing efficiency of straight, serpentine, and spiral micromixers was compared, while keeping the same axial length of each channel to compact the size of the microfluidic device. Numerical simulations were performed for a range of Reynolds numbers in each micromixer. The results showed that the spiral micromixer had the highest mixing efficiency among all the considered micromixers.
Article
Chemistry, Analytical
Wenpeng Guo, Li Tang, Biqiang Zhou, Yingsing Fung
Summary: This paper presents the first report on the simple and rapid fabrication of an on-chip compact micromixer using laser-ablated irregular microspheric surfaces on a polymethyl methacrylate (PMMA) microfluidic chip for continuous mixing in modular microfluidics. The micromixer is designed for sequential mixing of nanoliter fluids in about 1 second, and can achieve up to 90% fluid mixing in a short channel under optimized conditions. Computational flow dynamics simulations and experimental results demonstrate good agreement.
Article
Engineering, Chemical
Fang Yang, Wei Zhao, Guiren Wang
Summary: Electrokinetic (EK) micromixers have been widely studied, but they usually require different electrical conductivity between the fluids to be mixed. This study presents a method to enhance mixing between fluids with identical conductivity using an EK micromixer with conductive sidewalls. The results show that the mixing becomes stronger with increased conductivity value. This method provides a novel and convenient strategy for mixing fluids with the same or similar electrical conductivity in microfluidic systems.
CHINESE JOURNAL OF CHEMICAL ENGINEERING
(2022)
Article
Engineering, Environmental
Xin Dong, Kentaro Yaji, Xiaomin Liu
Summary: This paper investigates the design of the mixing unit in a T-shape micromixer considering non-Newtonian fluid effects using topology optimization. The optimized structures exhibit superior performance in maximizing mixing quality, especially for non-Newtonian fluids.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Chemical
Fahizan Mahmud, Khairul Fikri Tamrin, Shahrol Mohamaddan, Nobuo Watanabe
Summary: This study simplifies the manufacturing process and improves mixing performance by externally applying ultrasound and thermal energy upstream of the micromixer. The Dean micromixer shows higher mixing performance compared to T- and Y-micromixers, with about 27% improvement for Reynolds numbers between 40 and 100.
Article
Thermodynamics
Junsheng Wang, Qiaoyu Feng, Junzhu Yao, Kai Zhao
Summary: A novel T-type electromagnetic micromixer was proposed by combining the effects of laminar flow with Lorentz force. The effects of various parameters on the fluid mixing in the micromixer were numerically investigated, and the mixing efficiency achieved as high as approximately 97% by adjusting these parameters.
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2023)
Article
Chemistry, Analytical
Mojtaba Zeraatkar, Marco D. de Tullio, Gianluca Percoco
Summary: The demand for accessible and affordable microfluidic devices has led to the development of new manufacturing methods like 3D printing to replace traditional techniques. Through fused filament fabrication (FFF) 3D printing, microfluidic micromixers were created to address the challenge of enhancing the mixing process in microfluidic devices. A design of experiment demonstrated the impact of different parameters on mixing performance in printed devices, showing the inherent property of ridges formed on microchannels due to the FFF process.
Article
Engineering, Chemical
William L. N. Buglie, Khairul Fikri Tamrin, Nadeem Ahmed Sheikh, Mohd Fairus Mohd Yasin, Shahrol Mohamaddan
Summary: A two-dimensional Tesla micromixer was experimentally characterized to analyze its performance under different Reynolds numbers and valve stages. The study found that the low Reynolds number regime showed steady incremental mixing, while the high Reynolds number regime displayed enhanced mixing, particularly at the first valve. This was primarily due to the amplified opposing flow from the helix branch, resulting in stronger chaotic advection in the main microchannel. Interestingly, the measured mixing performance of the two-dimensional micromixer was comparable to that of three-dimensional passive micromixers reported in previous literature.
CHEMICAL ENGINEERING & TECHNOLOGY
(2022)
Article
Engineering, Multidisciplinary
Ramezan Ali Taheri, Vahabodin Goodarzi
Summary: A high effective micromixer with baffles and curved walls is proposed in this study to enhance mixing efficiency. Numerical analysis and experimental validation show that the centrifugal force and flow separation are the major factors contributing to the improvement of mixing efficiency. The micromixer is able to achieve species mixing of about 100%, which is 61.58% higher than the conventional design.
ENGINEERING ANALYSIS WITH BOUNDARY ELEMENTS
(2022)
Article
Biochemical Research Methods
Sisi Huang, Yihao Wu, Yifan Wang, Xiaoling Hu, Kui Song
Summary: This research proposes and studies an embedded obstacle-type micromixer-concentration gradient generator based on capillary self-driven. The experimental results agree with the simulation results. The mixing efficiency increases along both the mixing channel and palisade length, with higher efficiency in the middle small channel of the palisade-shape area and lower efficiency on both sides.
Article
Chemistry, Analytical
Sintayehu Assefa Endaylalu, Wei-Hsin Tien
Summary: This study investigated the mixing performance in a Y-junction microchannel with acoustic streaming through numerical simulation. Acoustic streaming significantly increased vorticity and improved mixing performance, with further enhancements achieved at lower inlet velocities, sharper vertex angles, and higher oscillation amplitudes. Integration of triangular structures both at the junction and sidewall regions led to the best mixing index results.
Article
Chemistry, Analytical
Prachet Dsk, Petru S. Fodor, Chandrasekhar R. Kothapalli
Summary: Miniaturization of liquid chromatography has the potential to enhance sensitivity, reduce solvent usage, and detect small quantities of peptides. In this study, a mixer design based on the inline Kenics geometry was developed to achieve rapid mixing in laminar flow regimes. The design was optimized and demonstrated robust performance even when the mixing section was flexible or when the chemical composition of the mobile phase was changed.
Article
Engineering, Environmental
Chin-Chung Tseng, Ruey-Jen Yang, Wei-Jhong Ju, Lung-Ming Fu
CHEMICAL ENGINEERING JOURNAL
(2018)
Article
Nanoscience & Nanotechnology
Van-Phung Mai, Cheng-Hao Ku, Ruey-Jen Yang
MICROFLUIDICS AND NANOFLUIDICS
(2019)
Article
Energy & Fuels
Yu-Yuan Sun, Van-Phung Mai, Ruey-Jen Yang
Article
Nanoscience & Nanotechnology
Woon-Shing Yeung, Fu-Yao Yang, Ruey-Jen Yang
Article
Physics, Applied
Woon-Shing Yeung, Van-Phung Mai, Ruey-Jen Yang
PHYSICAL REVIEW APPLIED
(2020)
Article
Physics, Applied
Fu-Yao Yang, Fu-Sui Hung, Woon-Shing Yeung, Ruey-Jen Yang
Summary: This study proposes an optimization method for the design of planar arbitrary-geometry thermal cloaks using natural materials based on the bilayer theory in thermal-cloaking studies. The method aims to provide a practical design method for improved thermal-cloaking performance.
PHYSICAL REVIEW APPLIED
(2021)
Article
Chemistry, Analytical
Wei-Hao Huang, Van-Phung Mai, Ruo-Yin Wu, Ko-Li Yeh, Ruey-Jen Yang
Summary: This study proposes a sensor for detecting mercury and lead ions using graphene oxide and aptamer solution, with detection limits lower than the maximum limits set by the World Health Organization for drinking water.
Article
Chemistry, Multidisciplinary
Van-Phung Mai, Wei-Hao Huang, Ruey-Jen Yang
Summary: Thermo-osmotic energy conversion using waste heat is a method of harvesting sustainable energy while reducing environmental impacts. This study investigates the effect of surface charge and pH value on thermo-osmotic performance through numerical simulation, and finds that pH level has a significant impact on enhancing the thermo-osmotic conversion efficiency.
Article
Thermodynamics
Van-Phung Mai, Tsung-Yu Lee, Ruey-Jen Yang
Summary: This study fabricated different types of droplet-triboelectric nanogenerators and investigated the effect of electrowetting-assisted charge injection on their performance. The results showed that composite materials doped with silk powder and polytetrafluoroethylene particles significantly increased the output current, and further performance enhancement could be achieved through appropriate design of the dielectric layer and operating conditions.
Article
Engineering, Chemical
Van-Phung Mai, Wei-Hao Huang, Yong-Lin Chang, Ruey-Jen Yang
Summary: This study investigates the capillary-driven energy conversion performance of a 2D composite membrane consisting of a graphene oxide (GO) matrix and natural silk fibers. The results show that the composite structure of the GO@silk membrane provides enhanced physical robustness and improved ion selectivity. The experimental results demonstrate high voltage and current outputs of 0.22 V and 12 μA, respectively, indicating the feasibility of using composite membrane structures for environmental energy conversion on a larger scale.
JOURNAL OF MEMBRANE SCIENCE
(2023)
Article
Thermodynamics
Wei-Hao Huang, Chih-Chang Chang, Ruey-Jen Yang
Summary: This study conducted numerical simulations to investigate the thermoelectric response in nanofluidic channels with slip mechanism. The results showed that temperature-dependent ion electrophoretic mobility and thermoosmosis dominate the thermoelectric performance. This study provides valuable insights for developing efficient nanofluidic-based thermoelectric generators.
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2023)
Article
Mechanics
Woon-Shing Yeung, Fu-Sui Hung, Van-Phung Mai, Ruey-Jen Yang
Summary: This paper presents a theoretical analysis of steady-state creeping flow in a composite porous domain with coupling heat transfer. The findings have important applications in thermal cloaking studies.
JOURNAL OF MECHANICS
(2022)
Review
Engineering, Environmental
Van-Phung Mai, Wei-Hao Huang, Ruey-Jen Yang
Summary: Blue energy, also known as salinity gradient energy, is considered a highly attractive solution for sustainable clean energy generation through ion transport via nanopassages like nanopores. This review discusses opportunities and challenges in ion transport through membranes of different dimensions, introduces strategies for enhancing ion transport and system performance, and explores mechanisms for improving ion transport through nanopores in the pursuit of harnessing blue energy efficiently in the future.
ACS ES&T ENGINEERING
(2021)
Article
Mechanics
Mahalakshmi Thangavelu, Nithyadevi Nagarajan, Hakan F. Oztop, Ruey-Jen Yang
Summary: Simulations were conducted to investigate magnetohydrodynamic convection of an Ag-water nanofluid in an inclined enclosure with a center heater, showing that heat transfer performance is influenced by the inclination angle and Hartmann number. Optimal heat transfer performance was achieved under specific conditions, and the heat transfer performance improves with an increasing volume fraction of nanoparticles.
JOURNAL OF MECHANICS
(2021)
Article
Chemistry, Multidisciplinary
Van-Phung Mai, Ruey-Jen Yang