Journal
MICROELECTRONIC ENGINEERING
Volume 111, Issue -, Pages 310-313Publisher
ELSEVIER
DOI: 10.1016/j.mee.2013.02.021
Keywords
Dextran coated magnetic nanoparticle; Sterilization; Autoclave; Filtration; UV irradiation
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Funding
- Seed Funding for Basic Research of the University of Hong Kong
- General Research Fund of the Research Grants Council [HKU 704911P]
- University Grants Council of Hong Kong [AoE/P-04/08]
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Dextran-coated magnetic iron oxide nanoparticles (DMNPs) have attracted significant attention for their many applications in biomedical area such as diagnostic magnetic resonance imaging (MRI), and gene therapy. For biomedical applications, nanoparticles must be sterile, and several terminal sterilization methods can be used. However, very little is known regarding the effect of sterilization methods on the properties of DMNPs. It is crucial to find out whether the DMNPs are affected by the sterilization process. This paper reported the influences on the physicochemical properties of DMNPs from four different methods: autoclaving, sterile filtration, UV irradiation and chemical sterilization with ethanol. In addition, cell viability was also studied. Our results indicate that filter sterilization changes the iron oxide/dextran ratio in DMNPs sample significantly. Besides, the autoclaving and ethanol treatment affected the polydispersity index of DMNPs sample. Thus, caution must be taken when choosing an appropriate method to perform sterilization for DMNPs. (C) 2013 Elsevier B.V. All rights reserved.
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