Journal
MICROELECTRONIC ENGINEERING
Volume 108, Issue -, Pages 76-81Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mee.2013.04.003
Keywords
Hydrogel; Self-folding; Nanopattern; Scaffold
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Funding
- EPSRC
- James Watt Nanofabrication Centre
- Engineering and Physical Sciences Research Council [1391550] Funding Source: researchfish
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Current progress in tissue engineering is focused on the creation of environments in which cultures of relevant cells can adhere, grow and form functional tissue. We propose a method for controlled chemical and topographical cues through surface patterning of self-folding hydrogel films. This provides a conversion of 2D patterning techniques into a viable method of manufacturing a 3D scaffold. While similar bilayers have previously been demonstrated, here we present a faster and high throughput process for fabricating self-folding hydrogel devices incorporating controllable surface nanotopographies by serial hot embossing of sacrificial layers and photolithography. (c) 2013 Elsevier B.V. All rights reserved.
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