Journal
MICROELECTRONIC ENGINEERING
Volume 87, Issue 5-8, Pages 753-755Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mee.2009.11.148
Keywords
BioFETs; Protein interaction; SU-8
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An extended-gate MOSFETs (metal-oxide-semiconductor field-effect transistors) based biosensing linear array has been fabricated for label-free protein interaction detection. The device was realized using a combination of very low leakage current MOSFET transistors and an external gate where the chemical reaction would take place. Peptide aptamers that recognize cyclin-dependent kinase (CDK), a protein cancer marker, were used as a biological test system. The test results showed a high sensitive in the detection of CDK. (C) 2009 Elsevier B.V. All rights reserved.
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