Lymphatics: At the Interface of Immunity, Tolerance, and Tumor Metastasis

Targeting the Effector Site with IFN-  -Inducing TLR Ligands Reactivates Tumor-Resident CD8 T Cell Responses to Eradicate Established Solid Tumors

(2014) A. J. Currie et al.   JOURNAL OF IMMUNOLOGY

Foxp3+ Regulatory T Cells Control Humoral Autoimmunity by Suppressing the Development of Long-Lived Plasma Cells

(2011) E. Jang et al.   JOURNAL OF IMMUNOLOGY

Stromal expression of vascular endothelial growth factor C is relevant to predict sentinel lymph node status in melanomas

(2011) Elena Gallego et al.   VIRCHOWS ARCHIV

Lymph Angiogenesis After Lung Transplantation and Relation to Acute Organ Rejection in Humans

(2010) Alexey Dashkevich et al.   ANNALS OF THORACIC SURGERY

Engineered silk fibroin protein 3D matrices for in vitro tumor model

(2010) Sarmistha Talukdar et al.   BIOMATERIALS

Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation

(2010) P. Uhrin et al.   BLOOD

Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling

(2010) C. C. Bertozzi et al.   BLOOD

Lymphotoxin-alpha contributes to lymphangiogenesis

(2010) R. H. Mounzer et al.   BLOOD

Chemotrap-1: An Engineered Soluble Receptor That Blocks Chemokine-Induced Migration of Metastatic Cancer Cells In vivo

(2010) S. Lanati et al.   CANCER RESEARCH

Transmural Flow Modulates Cell and Fluid Transport Functions of Lymphatic Endothelium

(2010) Dimana O. Miteva et al.   CIRCULATION RESEARCH

Development and Hormonal Regulation of the Ovarian Lymphatic Vasculature

(2010) Hannah M. Brown et al.   ENDOCRINOLOGY

Heterogeneous expression of toll-like receptors in lymphatic endothelial cells derived from different tissues

(2010) Emirena Garrafa et al.   IMMUNOLOGY AND CELL BIOLOGY

Lymphotoxin-β receptor activation by lymphotoxin-α1β2 and LIGHT promotes tumor growth in an NFκB-dependent manner

(2010) Barbara Daller et al.   INTERNATIONAL JOURNAL OF CANCER

Tumor masses support naive T cell infiltration, activation, and differentiation into effectors

(2010) Elizabeth D. Thompson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lymph node–resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation

(2010) Jarish N. Cohen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions

(2010) Anne L. Fletcher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lymphatic Endothelial Murine Chloride Channel Calcium-Activated 1 Is a Ligand for Leukocyte LFA-1 and Mac-1

(2010) M. Furuya et al.   JOURNAL OF IMMUNOLOGY

B Cell-Derived Vascular Endothelial Growth Factor A Promotes Lymphangiogenesis and High Endothelial Venule Expansion in Lymph Nodes

(2010) B. Shrestha et al.   JOURNAL OF IMMUNOLOGY

The Human Cutaneous Squamous Cell Carcinoma Microenvironment Is Characterized by Increased Lymphatic Density and Enhanced Expression of Macrophage-Derived VEGF-C

(2010) Dariush Moussai et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

CCR7 Mediates Directed Growth of Melanomas Towards Lymphatics

(2010) MAXINE S. EMMETT et al.   MICROCIRCULATION

Stereotypical Chronic Lymphocytic Leukemia B-Cell Receptors Recognize Survival Promoting Antigens on Stromal Cells

(2010) Mascha Binder et al.   PLoS One

Induction of Lymphoidlike Stroma and Immune Escape by Tumors That Express the Chemokine CCL21

(2010) J. D. Shields et al.   SCIENCE

Lymphangiogenesis Associated With Acute Cellular Rejection in Rat Liver Transplantation

(2010) E. Ishii et al.   TRANSPLANTATION PROCEEDINGS

Engineering a scaffold-free 3D tumor model for in vitro drug penetration studies

(2009) Siew-Min Ong et al.   BIOMATERIALS

Effects of VEGFR-3 phosphorylation inhibitor on lymph node metastasis in an orthotopic diffuse-type gastric carcinoma model

(2009) M Yashiro et al.   BRITISH JOURNAL OF CANCER

A Lymphotoxin-Driven Pathway to Hepatocellular Carcinoma

(2009) Johannes Haybaeck et al.   CANCER CELL

Crucial role of corneal lymphangiogenesis for allograft rejection in alkali-burned cornea bed

(2009) Shiqi Ling et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

The Expression of Vascular Endothelial Growth Factor C in Transplanted Corneas

(2009) Shiqi Ling et al.   CURRENT EYE RESEARCH

Regulatory T Cells Sequentially Migrate from Inflamed Tissues to Draining Lymph Nodes to Suppress the Alloimmune Response

(2009) Nan Zhang et al.   IMMUNITY

Conduits Mediate Transport of Low-Molecular-Weight Antigen to Lymph Node Follicles

(2009) Ramon Roozendaal et al.   IMMUNITY

CCR7 Deficiency in NOD Mice Leads to Thyroiditis and Primary Hypothyroidism

(2009) A. P. Martin et al.   JOURNAL OF IMMUNOLOGY

Inflammation Recapitulates the Ontogeny of Lymphoid Stromal Cells

(2009) L. Peduto et al.   JOURNAL OF IMMUNOLOGY

Fluid Flow Regulates Stromal Cell Organization and CCL21 Expression in a Tissue-Engineered Lymph Node Microenvironment

(2009) A. A. Tomei et al.   JOURNAL OF IMMUNOLOGY

LT R Signaling Induces Cytokine Expression and Up-Regulates Lymphangiogenic Factors in Lymph Node Anlagen

(2009) M. F. Vondenhoff et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Lymphatic Vessels, Not Blood Vessels, Primarily Mediate Immune Rejections After Transplantation

(2009) T. Dietrich et al.   JOURNAL OF IMMUNOLOGY

Identification of a novel 12p13.3 amplicon in nasopharyngeal carcinoma

(2009) Yvonne Y-Y Or et al.   JOURNAL OF PATHOLOGY

Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines

(2009) Ashley L St John et al.   NATURE MEDICINE

Nanoparticle-Delivered Multimeric Soluble CD40L DNA Combined with Toll-Like Receptor Agonists as a Treatment for Melanoma

(2009) Geoffrey W. Stone et al.   PLoS One

Targeting lymphotoxin-mediated negative selection to prevent prostate cancer in mice with genetic predisposition

(2009) P. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CCR7-mediated migration of developing thymocytes to the medulla is essential for negative selection to tissue-restricted antigens

(2009) T. Nitta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of Secondary Lymphoid Organs

(2008) Troy D. Randall et al.   Annual Review of Immunology

Suppression of Prostate Cancer Nodal and Systemic Metastasis by Blockade of the Lymphangiogenic Axis

(2008) J. B. Burton et al.   CANCER RESEARCH

Vascular Endothelial Growth Factor-C and C-C Chemokine Receptor 7 in Tumor Cell-Lymphatic Cross-talk Promote Invasive Phenotype

(2008) A. Issa et al.   CANCER RESEARCH

Differential expression of CCR7 defines two distinct subsets of human memory CD4+CD25+ Tregs

(2008) Valeria Tosello et al.   CLINICAL IMMUNOLOGY

The conduit system of the lymph node

(2008) R. Roozendaal et al.   INTERNATIONAL IMMUNOLOGY

Podoplanin expression by cancer associated fibroblasts predicts poor prognosis of lung adenocarcinoma

(2008) Akikazu Kawase et al.   INTERNATIONAL JOURNAL OF CANCER

The Lymphotoxin-β Receptor Is an Upstream Activator of NF-κB-mediated Transcription in Melanoma Cells

(2008) Punita Dhawan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Long-Term Survival for Patients With Non–Small-Cell Lung Cancer With Intratumoral Lymphoid Structures

(2008) Marie-Caroline Dieu-Nosjean et al.   JOURNAL OF CLINICAL ONCOLOGY

Tumor-derived TGF-β Mediates Conversion of CD4+Foxp3+ Regulatory T Cells in a Murine Model of Pancreas Cancer

(2008) Tricia A. Moo-Young et al.   JOURNAL OF IMMUNOTHERAPY

Pre-clinical characterization of GMP grade CCL21-gene modified dendritic cells for application in a phase I trial in Non-Small Cell Lung Cancer

(2008) Felicita Baratelli et al.   Journal of Translational Medicine

Fibroblastic reticular cells of the peripheral lymphoid organs: Unique features of a ubiquitous cell type

(2008) Péter Balogh et al.   MOLECULAR IMMUNOLOGY

Murine ovarian cancer vascular leukocytes require arginase-1 activity for T cell suppression

(2008) S. Peter Bak et al.   MOLECULAR IMMUNOLOGY

Restoration of lymphoid organ integrity through the interaction of lymphoid tissue–inducer cells with stroma of the T cell zone

(2008) Elke Scandella et al.   NATURE IMMUNOLOGY

TLR signaling by tumor and immune cells: a double-edged sword

(2008) B Huang et al.   ONCOGENE

Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase

(2008) A. J. Muller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA