Journal
MICROCHIMICA ACTA
Volume 180, Issue 5-6, Pages 355-361Publisher
SPRINGER WIEN
DOI: 10.1007/s00604-012-0931-1
Keywords
Rutin; Bovine serum albumin; Carbon-coated nickel nanoparticles; Interaction
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Funding
- National Natural Science Foundation of China [20575017]
- Natural Science Fund for Creative Research Groups of Hubei Province of China [2011CDA111]
- Educational Commission of Hubei Province of China [D20113004]
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We report on a glassy carbon electrode modified with carbon-coated nickel nanoparticles (C-Ni/GCE) that can be used to study the electrochemical properties of rutin and its interaction with bovine serum albumin (BSA) via cyclic voltammetry and differential pulse voltammetry. The effects of pH value, accumulation potential, accumulation time and reaction time were optimized. A pair of reversible peaks is found in the potential range of 0 to around 0.6 V at pH 5.0. Two linear response ranges (with different slopes) are found, one in the 2 to 210 nM concentration range, the other between 0.21 and 1.72 mu M. The detection limit is as low as 0.6 nM. On addition of BSA to the rutin solution, a decrease of the current is observed that is proportional to the concentration of BSA. The binding constant and stoichiometric ratio were calculated.
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