Journal
MICROBIOLOGY AND IMMUNOLOGY
Volume 62, Issue 11, Pages 732-736Publisher
WILEY
DOI: 10.1111/1348-0421.12650
Keywords
atopic dermatitis; IL-4; keratinocytes; microRNA
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Funding
- Albert H. and Mary Jane Slepyan Endowed Fellowship
- Dr. Orville J. Stone Endowed Professorship
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IL-4 plays an important role in the pathogenesis of atopic dermatitis (AD) by dysregulating many key factors at the transcriptional level. In this study, a microRNA array technique and IL-4 transgenic mice were used to demonstrate that IL-4 dysregulates microRNAs involved in inflammation, angiogenesis, lymphangiogenesis and apoptosis. Of the 372 common microRNAs examined, 26 and one microRNAs were found to be up- and down-regulated, respectively. MicroRNA-101-5p, -122-5p, -142-3p, -204-5p, -335-3p, -376a-3p, -378a-5p, -639 and -9-5p are among the most significantly up-regulated microRNAs. MicroRNA-147a, the only one that was down- regulated in the present study, attenuates TLR-induced inflammatory responses. These dysregulated microRNAs may provide post-transcriptional regulation of key genes in AD.
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