Article
Infectious Diseases
Ellen Vancutsem, Florence Crombe, Oriane Soetens, Magali Wautier, Corinna Dordelmann, Denis Pierard, Ingrid Wybo, Thomas Demuyser
Summary: Quantification of EBV DNA is crucial in transplantation settings for post-transplantation diagnosis. This study evaluated the performance of the AltoStar (R) EBV PCR Kit 1.5 on whole blood samples and found it to be reliable and accurate, with good sensitivity and linear range for EBV viral load determination.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Microbiology
Wei Wang, Xin Chen, Jie Pan, Xianhui Zhang, Liyun Zhang
Summary: This study found a high prevalence of EBV and CMV in Chinese IBD patients, and their prevalence is associated with clinical disease activities. Additionally, viral load in the intestinal mucosa is correlated with mucosal status. Quantitative real-time PCR is an effective method for monitoring EBV and CMV infection in IBD patients.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Deborah K. Johnson, Kaylia M. Reynolds, Brian D. Poole, Matthew D. Montierth, Vera M. Todd, April Barnado, Mary F. Davis
Summary: Patients with autoimmune disorders have altered cancer risks compared to the general population, with a strong association between viral infection and increased cancer risk. SLE and MS patients are more susceptible to viral infections, and preventing viral infections through vaccination may help control cancer risk for these patients.
Article
Immunology
Mariann Gyoengyoesi, Dominika Lukovic, Julia Mester-Tonczar, Katrin Zlabinger, Patrick Einzinger, Andreas Spannbauer, Victor Schweiger, Katharina Schefberger, Eslam Samaha, Jutta Bergler-Klein, Martin Riesenhuber, Christian Nitsche, Christian Hengstenberg, Patrick Mucher, Helmuth Haslacher, Monika Breuer, Robert Strassl, Elisabeth Puchhammer-Stoeckl, Christian Loewe, Dietrich Beitzke, Ena Hasimbegovic, Thomas A. Zelniker
Summary: This study evaluated the reactivation of parvovirus-B19 and Herpesviridae family members in patients with long-COVID syndrome and found that vaccination with monovalent COVID-19 vaccines was associated with reduced fatigue and multiorgan symptoms. It also led to lower levels of DNA virus-related IgM, plasma IgG subfractions, cytomegalovirus IgG and IgM, and EBV IgM titers.
Article
Microbiology
Katherine A. Willard, Ashley P. Barry, Cliff I. Oduor, John Michael Ong'echa, Jeffrey A. Bailey, Ann M. Moormann, Micah A. Luftig
Summary: In this study, we describe an unusual spontaneous lytic phenotype in EBV strains isolated from Kenyan endemic Burkitt lymphoma patients. These findings provide insight into viral and host factors involved in this process and the potential contribution of promiscuous lytic activity to the formation of EBV-associated diseases.
Article
Multidisciplinary Sciences
Bin Yang, Jilie Kong, Xueen Fang
Summary: Researchers demonstrate an on-line wearable microneedle patch for real-time capture and monitoring of universal cell-free DNA.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Meichun Zeng, Qingjun Jia, Jingjing Chen, Liming Xu, Li Xie, Qinglin Cheng, Qingchun Li, Ming Xiao, Zijian Fang
Summary: The relationship between plasma EBV-DNA load (PEDL) and Epstein-Barr virus (EBV)-encoded small RNA (EBER) during the early treatment of lymphoma is not well-established. This study found that although EBER affects the levels of PEDL, there is poor concordance between EBER and qualitative analysis of PEDL (qPEDL).
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Environmental Sciences
Wang Wen Jun, Feng Shun Qiao, He Feng, Du Hai Jun, Feng Miao, Wang Rui Fang, Mei Guo Yong, Liu Mi, Liu Rong, Yao Hai Lan, Han Jun
Summary: Objective: To detect the EBV viral load in children after HSCT using cdPCR. Methods: The sensitivity and specificity of cdPCR were evaluated, and serum samples of 64 children after HSCT were collected and analyzed. Results: cdPCR showed good sensitivity and specificity, and the incidence of EBV infection was 18.75% in the study population. Children with EBV infection had a longer average hospital stay compared to those without EBV infection.
BIOMEDICAL AND ENVIRONMENTAL SCIENCES
(2022)
Article
Virology
Lingtong Huang, Xuan Zhang, Lisha Pang, Peng Sheng, Yanqiu Wang, Fan Yang, Huili Yu, Xiaohan Huang, Yue Zhu, Ning Zhang, Hongliu Cai, Lingling Tang, Xueling Fang
Summary: This study aimed to assess the landscape and clinical features of viral reactivation in the early onset of severe pneumonia in ICU patients. The most common reactivated viruses in the lower respiratory tract of patients with severe pneumonia were cytomegalovirus (CMV), herpes simplex virus-1 (HSV-1), and Epstein-Barr virus (EBV). Viral reactivation was associated with an increased risk of mortality.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Immunology
Jennifer A. Slyker, Brandon Guthrie, Mark Pankau, Kenneth Tapia, Dalton Wamalwa, Sarah Benki-Nugent, Evelyn Ngugi, Meei-Li Huang, Irene Njuguna, Agnes Langat, Grace John-Stewart, Dara Lehman
Summary: The study found that co-infections of CMV and EBV were associated with higher HIV reservoir levels in Kenyan children with suppressed HIV RNA, suggesting that delaying or controlling CMV and EBV infections may be novel strategies to limit HIV reservoir formation.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Julien Lupo, Raphaele Germi, Remi Lancar, Michele Algarte-Genin, Houria Hendel-Chavez, Yassine Taoufik, Nicolas Mounier, Marialuisa Partisani, Fabrice Bonnet, Marie-Caroline Meyohas, Bruno Marchou, Anastasiia Filippova, Sophie Prevot, Dominique Costagliola, Patrice Morand, Caroline Besson
Summary: In the modern cART era, the EBV DNA load in whole blood and plasma at NHL diagnosis does not serve as prognostic markers for HIV-NHL patients.
Article
Virology
Agnieszka Jablonska, Branislav Zagrapan, Edyta Paradowska, Christoph Neumayer, Wolf Eilenberg, Christine Brostjan, Markus Klinger, Josif Nanobachvili, Ihor Huk
Summary: The study found that CMV infection may stimulate local inflammation in the aorta but is not a direct cause of most abdominal aortic aneurysms.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Emmanuela N. Bonglack, Joshua E. Messinger, Jana M. Cable, James Ch'ng, K. Mark Parnell, Nicolas M. Reinoso-Vizcaino, Ashley P. Barry, Veronica S. Russell, Sandeep S. Dave, Heather R. Christofk, Micah A. Luftig
Summary: The study found that EBV infection directly induced temporal expression of MCT1 and MCT4 in B lymphocytes, with MCT1 being crucial for early B cell proliferation and MCT4 upregulation leading to acquired resistance to MCT1 antagonism in LCLs. Dual inhibition of MCT1/4 resulted in growth arrest and lactate buildup in LCLs, suggesting a potential therapeutic approach for targeting viral lymphomas associated with EBV and KSHV.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Analytical
Yunyun Hu, Ye Tian, Haonan Di, Chengfeng Xue, Yanping Zheng, Bin Hu, Qin Lin, Xiaomei Yan
Summary: This study utilized nanoflow cytometry to examine surface proteins on extracellular vesicles and found that EVSUM5 and EVSUM2 can effectively differentiate NPC patients from NPG patients, providing a more accurate diagnostic method.
ANALYTICAL CHEMISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jaideep Mahendra, Little Mahendra, Dhana Divya, Paavai Ilango, Nalini Devarajan, Abirami Thanigaimalai
Summary: This study evaluates and compares the levels of lipocalin, adiponectin, and periodontal viruses in generalized periodontitis patients with and without diabetes mellitus. The results show that patients with diabetes and periodontitis have higher prevalence of EBV and CMV, as well as decreased levels of adiponectin, indicating an aggravation of the diabetic status among periodontitis patients and reinforcing the Periodontitis-DM continuum.
Article
Virology
Kazuhiro J. Fujimoto, Daniel C. F. Hobbs, Miki Umeda, Akihiro Nagata, Rie Yamaguchi, Yoshitaka Sato, Ayato Sato, Kohsuke Ohmatsu, Takashi Ooi, Takeshi Yanai, Hiroshi Kimura, Takayuki Murata
Summary: This study investigates the crucial elements that cause the difference in anti-SARS-CoV-2 activity of nafamostat and camostat, and indicates that the ease of covalent bond formation with Ser441 in TMPRSS2 possibly plays a major role in the anti-SARS-CoV-2 effect of nafamostat and its derivatives.
Article
Oncology
Satoru Kondo, Yusuke Okuno, Takayuki Murata, Hirotomo Dochi, Naohiro Wakisaka, Harue Mizokami, Makiko Moriyama-Kita, Eiji Kobayashi, Makoto Kano, Takeshi Komori, Nobuyuki Hirai, Takayoshi Ueno, Yosuke Nakanishi, Kazuhira Endo, Hisashi Sugimoto, Hiroshi Kimura, Tomokazu Yoshizaki
Summary: This study investigates the role of EBV in non-endemic nasopharyngeal carcinoma. The EBV genomes of Japanese NPC differ from those of other diseases in Japan or endemic NPC, and Japanese NPC is not affected by the endemic strain but frequently carries type 2 EBV or the strain with intermediate risk. The results highlight the importance of viral strains and viral reactivation in the pathogenesis of non-endemic NPC.
Letter
Pathology
Masashi Nishikubo, Nobuhiro Hiramoto, Daisuke Yamashita, Hiroharu Imoto, Yoshitaka Sato, Yusuke Okuno, Hironori Haga, Yasuhito Nannya, Seishi Ogawa, Hiroshi Kimura, Takayuki Ishikawa
PATHOLOGY INTERNATIONAL
(2022)
Article
Virology
Yusuke Yanagi, Yuya Hara, Seiyo Mabuchi, Takahiro Watanabe, Yoshitaka Sato, Hiroshi Kimura, Takayuki Murata
Summary: Reactivation of EBV leads to increased PD-L1 expression, which is induced through upregulation of EBNA2 and activation of signaling pathways. The expression of PD-L1 varies in different cell types.
Article
Cell Biology
Yoshitaka Sato, Masahiro Yaguchi, Yusuke Okuno, Hanako Ishimaru, Ken Sagou, Somi Ozaki, Takeshi Suzuki, Tomoki Inagaki, Miki Umeda, Takahiro Watanabe, Masahiro Fujimuro, Takayuki Murata, Hiroshi Kimura
Summary: This study found that the EBV-infected cells release exosomes containing a protein called BGLF2, which enhances viral gene expression and represses immune responses, thereby facilitating EBV infection.
CELL COMMUNICATION AND SIGNALING
(2022)
Review
Oncology
Hiroshi Kimura, Laurence de Leval, Qingqing Cai, Won Seog Kim
Summary: This review focuses on EBV-associated neoplasms derived from NK or T cells, which are rare but more prevalent in Asia and South America. The article discusses recent genomic discoveries and therapeutic developments in these aggressive disorders affecting children and adults.
CURRENT OPINION IN ONCOLOGY
(2022)
Article
Virology
Yuya Hara, Takahiro Watanabe, Masahiro Yoshida, H. M. Abdullah Al Masud, Hiromichi Kato, Tomohiro Kondo, Reiji Suzuki, Shutaro Kurose, Md Kamal Uddin, Masataka Arata, Shouhei Miyagi, Yusuke Yanagi, Yoshitaka Sato, Hiroshi Kimura, Takayuki Murata
Summary: EBV, a significant public health challenge causing infectious mononucleosis and cancer, remains poorly understood. This study identified and characterized protein-protein interactions (PPIs) of EBV, revealing the central role of BLRF2 in the viral life cycle and its potential as a drug development target.
JOURNAL OF VIROLOGY
(2022)
Review
Oncology
Rita Alaggio, Catalina Amador, Ioannis Anagnostopoulos, Ayoma D. Attygalle, Iguaracyra Barreto de Oliveira Araujo, Emilio Berti, Govind Bhagat, Anita Maria Borges, Daniel Boyer, Mariarita Calaminici, Amy Chadburn, John K. C. Chan, Wah Cheuk, Wee-Joo Chng, John K. Choi, Shih-Sung Chuang, Sarah E. Coupland, Magdalena Czader, Sandeep S. Dave, Daphne de Jong, Ming-Qing Du, Kojo S. Elenitoba-Johnson, Judith Ferry, Julia Geyer, Dita Gratzinger, Joan Guitart, Sumeet Gujral, Marian Harris, Christine J. Harrison, Sylvia Hartmann, Andreas Hochhaus, Patty M. Jansen, Kennosuke Karube, Werner Kempf, Joseph Khoury, Hiroshi Kimura, Wolfram Klapper, Alexandra E. Kovach, Shaji Kumar, Alexander J. Lazar, Stefano Lazzi, Lorenzo Leoncini, Nelson Leung, Vasiliki Leventaki, Xiao-Qiu Li, Megan S. Lim, Wei-Ping Liu, Abner Louissaint, Andrea Marcogliese, L. Jeffrey Medeiros, Michael Michal, Roberto N. Miranda, Christina Mitteldorf, Santiago Montes-Moreno, William Morice, Valentina Nardi, Kikkeri N. Naresh, Yasodha Natkunam, Siok-Bian Ng, Ilske Oschlies, German Ott, Marie Parrens, Melissa Pulitzer, S. Vincent Rajkumar, Andrew C. Rawstron, Karen Rech, Andreas Rosenwald, Jonathan Said, Clementine Sarkozy, Shahin Sayed, Caner Saygin, Anna Schuh, William Sewell, Reiner Siebert, Aliyah R. Sohani, Reuben Tooze, Alexandra Traverse-Glehen, Francisco Vega, Beatrice Vergier, Ashutosh D. Wechalekar, Brent Wood, Luc Xerri, Wenbin Xiao
Summary: This article provides an overview of the upcoming 5th edition of the World Health Organization classification of lymphoid tumors, highlighting changes from the previous edition such as reorganization of entities, modification of nomenclature, revision of diagnostic criteria, deletion of entities, introduction of new entities, and inclusion of tumor-like lesions.
Article
Biochemistry & Molecular Biology
Takayuki Murata, Satoko Iwahori, Yusuke Okuno, Hironori Nishitsuji, Yusuke Yanagi, Koichi Watashi, Takaji Wakita, Hiroshi Kimura, Kunitada Shimotohno
Summary: N6-methyladenosine (m(6)A) is a post-transcriptional RNA modification involved in various processes including transport, degradation, translation, and splicing. The study finds that HBV RNA is predominantly modified by m(6)A in the coding region of HBx. Mutations in the methylation sites reduce HBV mRNA and HBs protein levels. Inhibiting or knocking down m(6)A in primary hepatocytes decreases viral RNA and HBs protein levels in the medium, indicating the importance of m(6)A modification for efficient HBV replication in hepatocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Transplantation
Yosuke Nakaya, Hideo Koh, Naonori Harada, Hiroshi Okamura, Takuya Misugi, Tomoki Suekane, Daisuke Tachibana, Hiroshi Kimura, Masayuki Hino, Hirohisa Nakamae
Summary: A 32-year-old woman with chronic active Epstein-Barr virus infection experienced graft failure after her first allogeneic hematopoietic cell transplant. She then underwent a second transplant using haploidentical hematopoietic cells and posttransplant cyclophosphamide as salvage therapy. Neutrophils engrafted successfully on day 19, and the patient remained in remission without severe transplant-related complications for 10 months.
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2023)
Article
Dermatology
Yoji Hirai, Hideo Asada, Toshihisa Hamada, Jun-ichi Kawada, Hiroshi Kimura, Ayako Arai, Koichi Ohshima, Shouichi Ohga, Keiji Iwatsuki
Summary: Hydroa vacciniforme lymphoproliferative disorder (HV-LPD) and severe mosquito bite allergy (SMBA) are cutaneous forms of Epstein-Barr virus (EBV)-associated T/natural killer (NK) cell LPDs. They are closely related to chronic active EBV disease (CAEBV) and EBV-associated hemophagocytic lymphohistiocytosis (EBV-HLH). Diagnostic criteria and determination criteria for disease severity are proposed to define the disease spectrum of HV-LPD and SMBA. The proposed diagnostic criteria are in line with the guidelines for the management of CAEBV and related disorders 2023.
JOURNAL OF DERMATOLOGY
(2023)
Article
Virology
Md Kamal Uddin, Takahiro Watanabe, Masataka Arata, Yoshitaka Sato, Hiroshi Kimura, Takayuki Murata
Summary: Studies have shown that secretory vesicles derived from the trans-Golgi network or endosomes transport virions into the extracellular space, but the mechanism underlying the release of Epstein-Barr virus, a human oncovirus, remains unclear. In this study, we found that disruption of BBLF1, a tegument component, suppressed viral release and resulted in the accumulation of viral particles on the inner side of the vesicular membrane. Our findings suggest that BBLF1 regulates the viral release pathway and reveal a new aspect of tegument protein function.
JOURNAL OF VIROLOGY
(2023)
Review
Hematology
Jun-ichi Kawada, Yoshinori Ito, Koichi Ohshima, Masaki Yamada, Shinsuke Kataoka, Hideki Muramatsu, Akihisa Sawada, Taizo Wada, Ken-Ichi Imadome, Ayako Arai, Keiji Iwatsuki, Shouichi Ohga, Hiroshi Kimura
Summary: Chronic active Epstein-Barr virus disease (CAEBV) is a systemic inflammatory disease characterized by the clonal proliferation of Epstein-Barr virus (EBV)-infected T or NK cells. Updated guidelines for the diagnosis and treatment of CAEBV have been proposed, which include confirming a high copy number of EBV genome and infected cells, and considering hematopoietic stem cell transplantation (HSCT) as the only curative treatment.
INTERNATIONAL JOURNAL OF HEMATOLOGY
(2023)
Correction
Oncology
Rita Alaggio, Catalina Amador, Ioannis Anagnostopoulos, Ayoma D. Attygalle, Iguaracyra Barreto de Oliveira Araujo, Emilio Berti, Govind Bhagat, Anita Maria Borges, Daniel Boyer, Mariarita Calaminici, Amy Chadburn, John K. C. Chan, Wah Cheuk, Wee-Joo Chng, John K. Choi, Shih-Sung Chuang, Sarah E. Coupland, Magdalena Czader, Sandeep S. Dave, Daphne de Jong, Arianna Di Napoli, Ming-Qing Du, Kojo S. Elenitoba-Johnson, Judith Ferry, Julia Geyer, Dita Gratzinger, Joan Guitart, Sumeet Gujral, Marian Harris, Christine J. Harrison, Sylvia Hartmann, Andreas Hochhaus, Patty M. Jansen, Kennosuke Karube, Werner Kempf, Joseph Khoury, Hiroshi Kimura, Wolfram Klapper, Alexandra E. Kovach, Shaji Kumar, Alexander J. Lazar, Stefano Lazzi, Lorenzo Leoncini, Nelson Leung, Vasiliki Leventaki, Xiao-Qiu Li, Megan S. Lim, Wei-Ping Liu, Abner Louissaint, Andrea Marcogliese, L. Jeffrey Medeiros, Michael Michal, Roberto N. Miranda, Christina Mitteldorf, Santiago Montes-Moreno, William Morice, Valentina Nardi, Kikkeri N. Naresh, Yasodha Natkunam, Siok-Bian Ng, Ilske Oschlies, German Ott, Marie Parrens, Melissa Pulitzer, S. Vincent Rajkumar, Andrew C. Rawstron, Karen Rech, Andreas Rosenwald, Jonathan Said, Clementine Sarkozy, Shahin Sayed, Caner Saygin, Anna Schuh, William Sewell, Reiner Siebert, Aliyah R. Sohani, Ritsuro Suzuki, Reuben Tooze, Alexandra Traverse-Glehen, Francisco Vega, Beatrice Vergier, Ashutosh D. Wechalekar, Brent Wood, Luc Xerri, Wenbin Xiao, Norah Olubunmi Akinola, Yassmine Akkari, Luis M. Allende, Katsuyuki Aozasa, Iguaracyra Araujo, Luca Arcaini, Kirit M. Ardeshna, Naoko Asano, Andishe Attarbaschi, Chris M. Bacon, Sharon Louise Barrans, Tracy Batchelor, Maxime Battistella, Linda B. Baughn, Amir Behdad, Sigbjorn Berentsen, Giada Bianchi, Jacob Bledsoe, Peter Borchmann, Mark Bower, Barbara Buldini, Jan Andreas Burger, Birgit Burkhardt, Ryan D. Cassaday, Giovanni Cazzaniga, Nadine Cerf-Bensussan, Ethel Cesarman, Mammen Chandy, Jennifer R. Chapman, Bjorn Chapuy, Xueyan Chen, Chee Leong Cheng, Carlos Chiattone, Nicholas Chiorazzi, Lucy B. Cook, Wendy A. Cooper, Gregory Philip Corboy, Andrew John Cowan, Immacolata Cozzolino, Ian A. Cree, Emanuele S. G. d'Amore, Andrew John Davies, Martina Deckert, Jan Delabie, Elizabeth G. Demicco, Vikram Deshpande, Arjan Diepstra, Daan Dierickx, Kieron Dunleavy, Barbara Eichhorst, Daisuke Ennishi, David C. Fajgenbaum, Pedro Farinha, Carlos Fernandez de Larrea, Kevin E. Fisher, Jude Fitzgibbon, Melina Flanagan, Jonathan Fromm, Juan F. Garcia, William Robert Geddie, Morie Gertz, Ajay Gopal, Satish Gopal, Patricia Theresa Greipp, Alejandro Gru, Ritu Gupta, Martin-Leo Hansmann, Konnie M. Hebeda, Klaus Herfarth, Marco Herling, Olivier Hermine, Khe Hoang-Xuan, Jennelle Hodge, Shimin Hu, Yuhua Huang, Yin Pun Hung, Stephen Hunger, Hiroto Inaba, Hiroshi Inagaki, Javeed Iqbal, Kenji Ishitsuka, Noriko Iwaki, Keiji Iwatsuki, Nitin Jain, Yoon Kyung Jeon, Marshall Kadin, Sachiko Kaji, Aanchal Kakkar, Anastasios Karadimitris, Keisuke Kataoka, Seiichi Kato, Marie Jose Kersten, Rhett P. Ketterling, Ji Eun Kim, Christian P. Kratz, Robert Kridel, Sigurdur Kristinsson, Ralf Kuppers, Isinsu Kuzu, Yok-Lam, Ann Lacasce, Laurence Lamant-Rochaix, Thierry Lamy, Ola Landgren, Siddhartha Laskar, William Bradlyn Laskin, Georg Lenz, Shaoying Li, Gan Di Li, Pei Lin, Franco Locatelli, Robert Brian Lorsbach, Izidore Lossos, Thomas P. Jr Loughran, William R. Macon, Joseph J. Maleszewski, Pankaj Malhotra, Teresa Marafioti, Dai Maruyama, Alexander Marx, Sam M. Mbulaiteye, Veronique Meignin, Ester Mejstrikova, Pamela Michelow, Markku Miettinen, Rodney R. Miles, Hiroaki Miyoshi, Thierry Jo Molina, Manuela Mollejo, Shuji Momose, Tetsuya Mori, William G. Morice, Bertrand Nadel, Hirokazu Nagai, Motoo Nagane, Reena Nair, Naoya Nakamura, Atsuko Nakazawa, Samih Nasr, Andrew Gordon Nicholson, Alina Nicolae, Robert Shigeo Ohgami, Naoki Oishi, Timothy S. Olson, Nicolas Ortonne, Bruno Paiva, Qiang Pan-Hammarstrom, Mayur Parihar, Marco Paulli, Andrea Petersen, Jennifer Picarsic, Alessandro Pileri, Nicola Pimpinelli, Jose A. Plaza, Karen R. Rabin, Markus Raderer, Kanti Rai, Ulla Randen, Huilan Rao, Alistair Robson, Rosemary Rochford, Richard Rosenquist, Davide Rossi, Esther D. Rossi, Simon Rule, Grzegorz Rymkiewicz, Elena Sabattini, Vaskar Saha, Mamiko Sakata-Yanagimoto, Christian A. Sander, J. Martin Sangueza, Omar P. Sangueza, Marco Santucci, Yasuharu Sato, Akira Satou, Kristian Theo Schafernak, Fernando Schmitt, Gianpietro Semenzato, Manju Sengar, Tait Shanafelt, Kazuyuki Shimada, Graham W. Slack, Susan Slager, Riccardo Soffietti, David A. Solomon, Kostas Stamatopoulos, Christian Steidl, Stephan Stilgenbauer, Narittee Sukswai, Kengo Takeuchi, Giovanni Tallini, Junichi Tamaru, Soo-Yong Tan, Prashant Tembhare, Enrico Tiacci, Yoshiki Tokura, Olivier Tournilhac, Steven Treon, Lorenz Truemper, Kunihiro Tsukasaki, Frits van Rhee, Abraham Varghese, Maarten H. Vermeer, Philippe Vielh, Brian Walker, Michael Wang, Huan-You Wang, Zhe Wang, Takashi Watanabe, Oliver Weigert, David Wein-Stock, Sean J. Whittaker, Rein Willemze, Wilhelm Woessmann, Catherine J. Wu, Motoko Yamaguchi, Hidetaka Yamamoto, Daisuke Yamashita, Shenmiao Yang, David T. Yang, Takahiko Yasuda, Wei-Hua Yin, Yoh Zen, Sha Zhao, Wei-Li Zhao
Article
Microbiology
Atsuko Sugimoto, Takahiro Watanabe, Kazuhiro Matsuoka, Yusuke Okuno, Yusuke Yanagi, Yohei Narita, Seiyo Mabuchi, Hiroyuki Nobusue, Eiji Sugihara, Masaya Hirayama, Tomihiko Ide, Takanori Onouchi, Yoshitaka Sato, Teru Kanda, Hideyuki Saya, Yasumasa Iwatani, Hiroshi Kimura, Takayuki Murata
Summary: In this study, EBV infection was found to induce the expression of the IMPDH2 gene, leading to nucleolar, nuclear, and cellular hypertrophy, as well as efficient cell proliferation. The use of an IMPDH2 inhibitor, MMF, was shown to suppress PTLD. These findings provide foundational evidence for understanding the mechanisms of B cell transformation induced by EBV.
MICROBIOLOGY SPECTRUM
(2023)