Article
Immunology
Yingze Ye, Zhihong Jian, Tong Jin, Yina Li, Zhi Zeng, Xu Zhang, Xiaoxing Xiong, Lijuan Gu
Summary: This study suggests that NADPH oxidase 2 (NOX2)-mediated reactive oxygen species (ROS) production exacerbates acute brain injury but promotes functional recovery after stroke. Inhibiting NOX2 activity can reduce infarct size and mortality, but may hinder functional recovery. This effect may be related to neuroinflammation, autophagy, angiogenesis, and the PI3K/Akt signaling pathway.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Materials Science, Biomaterials
Mousumi Baruah, Anal Jana, Mudassar Ali, Koyeli Mapa, Animesh Samanta
Summary: The innate immune system eliminates pathogens through phagocytosis and the production of reactive oxygen species (ROS), such as the pro-inflammatory oxidant hypochlorous acid (HOCl). This study developed a pentacyclic pyridinium probe, PM-S, to efficiently detect HOCl in the Nox2 pathway. The probe showed advantages in terms of stability, sensitivity, and specificity to mitochondria, providing a novel platform for monitoring the inflammatory process.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Cell Biology
Daniel Simoes de Jesus, Paula Bargi-Souza, Vinicius Cruzat, Vijay Yechoor, Angelo Rafael Carpinelli, Rodrigo Antonio Peliciari-Garcia
Summary: The pancreatic beta cells circadian clock and NADPH oxidase (NOX) family play important roles in glucose metabolism. Absence of BMAL1 may trigger an increase in NOX2-derived reactive oxygen species (ROS) in pancreatic beta cells, leading to inhibition of insulin secretion.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Anthony L. Sylvester, David X. Zhang, Sophia Ran, Natalya S. Zinkevich
Summary: Reactive oxygen species (ROS) play important roles in health and disease, with both beneficial and harmful effects. Different sources of ROS have different roles in various pathologies. NOX1 is associated with hypertension through ROS production, making it a promising therapeutic target. NOX2 and NOX4 produce hydrogen peroxide, influencing cellular processes. Increased ROS production from NOX5 contributes to atherosclerosis.
Review
Microbiology
Nadia Miranda, Katrina K. Hoyer
Summary: Valley fever, caused by inhaling a soil fungus called Coccidioides, triggers the formation of granulomas as an attempt by the immune system to control and eliminate the fungus. However, granulomas during Coccidioides infection are not well understood. This review examines our current knowledge of granulomas and their potential mechanisms, using it to uncover the formation of granulomas in coccidioidomycosis.
Article
Biochemistry & Molecular Biology
Hana Valenta, Sophie Dupre-Crochet, Mouna Abdesselem, Tania Bizouarn, Laura Baciou, Oliver Nusse, Ariane Deniset-Besseau, Marie Erard
Summary: The phagocyte NADPH oxidase is a key enzyme of the innate immune system, and the use of the chimeric protein Trimera can activate the enzyme and sustain high levels of activity, but it leads to intracellular acidification, apoptosis, and local peroxidation of lipids in the membrane.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Cell Biology
Yu Sugimoto, Daiki Endo, Yasuaki Aratani
Summary: In a zymosan-induced systemic inflammation model, CGD mice deficient in the phagocyte NADPH oxidase gp91phox subunit exhibited severe thymic atrophy and lymphopenia, along with enhanced neutrophilic inflammation, while showing increased circulating and splenic neutrophils and enhanced granulopoiesis compared with wild-type mice.
Article
Cell Biology
Junqiang Yan, Jiarui Huang, Anran Liu, Jiannan Wu, Hua Fan, Mengmeng Shen, Xiaoyi Lai, Hongxia Ma, Wenjie Sun, Jianxue Yang, Yunqi Xu
Summary: Parkinson's disease is a neurodegenerative disease caused by the loss of dopaminergic neurons. Atorvastatin was found to improve muscle capacity, anxiety, and depression by inhibiting NOX2, potentially through NOX2-mediated oxidative stress and autophagy. Atorvastatin may be a promising drug for improving behavioral disorders in PD, with NOX2 as a potential gene target for new drug development.
Review
Cell Biology
Marie-Helene Paclet, Salome Laurans, Sophie Dupre-Crochet
Summary: This article reviews the multiple roles of NOX2 in neutrophil functions, with a focus on the description of its components and their assembly mechanisms. It also explains the role of energy metabolism and phosphoinositides in regulating NADPH oxidase activity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yuanyuan Cao, Zhangwei Chen, Jianguo Jia, Ao Chen, Yanhua Gao, Juying Qian, Junbo Ge
Summary: The study found that rosuvastatin mitigates coronary microembolism (CME)-induced cardiac injury by inhibiting Nox2-induced ROS overproduction and alleviating p53/Bax/Bcl-2-dependent cardiomyocyte apoptosis.
CARDIOVASCULAR TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dezhen Tu, Ravikanth Velagapudi, Yun Gao, Jau-Shyong Hong, Hui Zhou, Hui-Ming Gao
Summary: This study investigates the expression patterns, regulatory mechanisms, and pathological roles of neuronal NADPH oxidase in inflammation-associated neurodegeneration. The results show that NOX2 is persistently upregulated in neurons during chronic neuroinflammation and is associated with oxidative stress and neurodegeneration. Inhibition of neuronal NOX2 can block the degenerative effects of inflammatory mediators and prevent neurodegeneration.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Shih-Heng Chen, Shuangyu Han, Chih-Fen Hu, Ran Zhou, Yun Gao, Dezhen Tu, Huiming Gao, Jing Feng, Yubao Wang, Ru-Band Lu, Jau-Shyong Hong
Summary: Recent studies have found that improper resolution of acute neuroinflammation can lead to long-lasting low-grade chronic neuroinflammation and progressive neurodegeneration. This study aimed to identify the potential pathways mediating chronic neuroinflammation and resultant neurodegeneration following LPS stimulation. The results showed that TLR-4 activation, which is essential for acute neuroinflammation, is not sufficient for maintaining chronic neuroinflammation. Instead, the MAC1-NOX2-ERK1/2 signaling pathway plays a crucial role in the initiation and maintenance of low-grade chronic neuroinflammation. Continuous activation of ERK1/2 and NOX2 in microglia forms a vicious cycle, sustaining the low-grade neuroinflammation and driving neurodegeneration.
Article
Biochemistry & Molecular Biology
Silvia S. Barbieri, Leonardo Sandrini, Laura Musazzi, Maurizio Popoli, Alessandro Ieraci
Summary: Anxiety disorders are common mental health diseases, with stress being a major risk factor. The study found that apocynin can prevent the development of anxiety-like phenotype, reduce histone acetylation decrease, and block the upregulation of specific biochemical molecules.
Article
Biochemistry & Molecular Biology
Carla Ijurko, Marta Romo-Gonzalez, Clara Garcia-Calvo, Jose Luis Sardina, Carmen Sanchez-Bernal, Jesus Sanchez-Yaguee, Benedicte Elena-Herrmann, Joran Villaret, Catherine Garrel, Julie Mondet, Pascal Mossuz, Angel Hernandez-Hernandez
Summary: Acute myeloid leukaemia (AML) is a highly heterogeneous disease, and the lack of NOX2 protein affects the metabolism control of AML cells. A panel of differentially expressed metabolic genes has been discovered, which has predictive value for AML prognosis and survival.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Hematology
Craig B. Harrison, Silvia Cellone Trevelin, Daniel A. Richards, Celio X. C. Santos, Greta Sawyer, Andrea Markovinovic, Xiaohong Zhang, Min Zhang, Alison C. Brewer, Xiaoke Yin, Manuel Mayr, Ajay M. Shah
Summary: Fibroblast-specific deficiency of Nox2 attenuated ANG II-induced vascular remodeling and hypertension in mice, suggesting a crucial role for fibroblast Nox2 in regulating paracrine signaling to vascular smooth muscle cells via factors such as GDF6.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Microbiology
Althea Campuzano, Natalia Castro-Lopez, Amanda J. Martinez, Michal A. Olszewski, Anutosh Ganguly, Chrissy Leopold Wager, Chiung-Yu Hung, Floyd L. Wormley
Article
Immunology
Celine A. Hayden, Danilo Landrock, Chiung Yu Hung, Gary Ostroff, Gina M. Fake, John H. Walker, Ann Kier, John A. Howard
Article
Immunology
Althea Campuzano, Hao Zhang, Gary R. Ostroff, Lucas dos Santos Dias, Marcel Wuthrich, Bruce S. Klein, Jieh-Juen Yu, Humberto H. Lara, Jose L. Lopez-Ribot, Chiung-Yu Hung
JOURNAL OF IMMUNOLOGY
(2020)
Article
Infectious Diseases
Carolina Rodriguez-Echeverri, Juan David Puerta-Arias, Angel Gonzalez
Summary: The study showed that P. brasiliensis can activate BM-MSCs, leading to an inflammatory response and the expression of inflammatory mediators, while also reducing the fungicidal effect on the fungus.
Article
Dermatology
Daniel Fernando Carrascal-Correa, Alejandra Zuluaga, Angel Gonzalez
Article
Nanoscience & Nanotechnology
Binita Shrestha, Lijun Wang, Hao Zhang, Chiung Yu Hung, Liang Tang
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Review
Microbiology
Angel Gonzalez
Review
Immunology
Juan David Puerta-Arias, Susana P. Mejia, Angel Gonzalez
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2020)
Article
Immunology
Carlos Alberto Pelaez-Jaramillo, Maria Del Pilar Jimenez-Alzate, Pedronel Araque-Marin, Chiung-Yu Hung, Natalia Castro-Lopez, Garry T. Cole
Summary: Coccidioides is a soil-borne fungal pathogen causing a respiratory disease, characterized by the formation of parasitic cells and secretion of lipid-rich cell membrane layer.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Cell & Tissue Engineering
Carolina Rodriguez-Echeverri, Angelica Bonilla-Porras, Angel Gonzalez
Summary: Adult stem cells have therapeutic potential, but they play complex roles in the immune responses of some infectious diseases. For example, certain fungal pathogens can influence the behavior of stem cells and mesenchymal stromal cells by inducing proliferation and differentiation, thereby affecting the immune response.
STEM CELLS AND DEVELOPMENT
(2021)
Editorial Material
Immunology
Angel Gonzalez, Carlos P. Taborda
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Microbiology
Theo N. Kirkland, David A. Stevens, Chiung-Yu Hung, Sinem Beyhan, John W. Taylor, Lisa F. Shubitz, Sascha H. Duttke, Arash Heidari, Royce H. Johnson, Stanley C. Deresinski, Antje Lauer, Joshua Fierer
Summary: Coccidioides immitis and posadasii are fungal species that cause coccidioidomycosis. They can infect both immunocompetent and immunocompromised individuals, with high infection rates in endemic areas. While most infections resolve spontaneously, some can be fatal. Extensive research has been conducted on Coccidioides and its associated disease over the past century. This review focuses on gathering the most important basic research studies on the mycology of these fungi, excluding host response and clinical studies, to provide a valuable resource for those interested in Coccidioides and coccidioidomycosis.
Article
Microbiology
Carolina Rodriguez-Echeverri, Beatriz L. Gomez, Angel Gonzalez
Summary: This study aims to investigate the impact of the interaction between hematopoietic stem cells and Histoplasma capsulatum on hematopoiesis. The results indicate that this interaction induces an immune response in hematopoietic stem cells, leading to apoptosis and altered proliferation. This may explain the clinical manifestations of anemia and pancytopenia in patients with severe histoplasmosis.
Review
Immunology
Sean Jeffreys, James P. Chambers, Jieh-Juen Yu, Chiung-Yu Hung, Thomas Forsthuber, Bernard P. Arulanandam
Summary: Acinetobacter baumannii is a drug-resistant bacteria that causes hospital-acquired infections, which have contributed to increased costs and mortality during the COVID-19 pandemic. Immune-based therapy, including vaccines and monoclonal antibodies, is a promising strategy to combat this pathogen.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Morgan E. Gorris, Karin Ardon-Dryer, Althea Campuzano, Laura R. Castanon-Olivares, Thomas E. Gill, Andrew Greene, Chiung-Yu Hung, Kimberly A. Kaufeld, Mark Lacy, Edith Sanchez-Paredes
Summary: Coccidioidomycosis (Valley fever) has been a recognized health threat in the US since the 1930s, but not all states are required to report cases. Mandating reporting of the disease across more states would increase awareness, improve outcomes, and aid in drug and vaccine development. This commentary advocates for reporting coccidioidomycosis in the US and surveillance in endemic regions to protect human health.