Article
Immunology
Jie Li, Hwai- Yang, Ming-Lun Yeh, Michael H. Le, An K. Le, Yee Hui Yeo, Chia-Yen Dai, Scott Barnett, Jian Q. Zhang, Jee-Fu Huang, Huy N. Trinh, Christopher Wong, Clifford Wong, Joseph K. Hoang, Ramsey Cheung, Ming-Lung Yu, Mindie H. Nguyen
Summary: This study found that concurrent FL in patients with CHB significantly reduces the risk of cirrhosis and HCC, as well as increases the rate of HBsAg seroclearance. Further research is needed to confirm these findings and investigate the underlying mechanisms of FL on CHB.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Gastroenterology & Hepatology
Qi Wang, Hong Zhao, You Deng, Huanwei Zheng, Huiling Xiang, Yuemin Nan, Jinhua Hu, Qinghua Meng, Xiaoyuan Xu, Jilian Fang, Jie Xu, Xiaoming Wang, Hong You, Calvin Q. Pan, Wen Xie, Jidong Jia
Summary: The study validates the Baveno VII definition of recompensation and explores the criteria for stable improvement of liver function tests in entecavir-treated patients with CHB-related decompensated cirrhosis. The study shows that over 50% of patients with hepatitis B-related decompensated cirrhosis treated with antivirals could recompensate and proposes laboratory criteria which could be used to define recompensation.
JOURNAL OF HEPATOLOGY
(2022)
Article
Multidisciplinary Sciences
Ting Mao, Bin Zhang, Ti Yang, Yinyan Qian, Chenchen Zhou, Chunyan He
Summary: This study compared the prognostic values of five lymphocyte-based scores in HBV-associated decompensated cirrhosis patients and found that the neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR) had superior prognostic ability for predicting 30-day mortality.
Article
Urology & Nephrology
Chloe Schwarz, Antoine Morel, Marie Matignon, Philippe Grimbert, Eric Rondeau, Nacera Ouali, Helene Francois, Laurent Mesnard, Camille Petit-Hoang, Cedric Rafat, Karine Dahan, Yosu Luque
Summary: Hepatitis B virus (HBV) reactivation was found to be high in kidney transplant recipients receiving belatacept, but did not impact patient survival. Further studies are needed to confirm these results.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Medical Laboratory Technology
Yanhua Yi, Donglin Zhu, Xiaojie Li, Zhizhi Xie, Bangqiang Xie, Yun Xi, Changzhi Xu
Summary: This study evaluated the effect of hepatitis B virus on coagulation parameters in patients with hepatitis B virus-related decompensated cirrhosis, suggesting that the virus has an impact on coagulation indicators in these patients, emphasizing the importance of early antiviral treatment.
CLINICAL LABORATORY
(2021)
Article
Immunology
Mingyu Li, Zheng Zong, Xinmiao Xiong, Jing Fan, Huan Zhong, Na Liu, Wei Ye, Jisheng Jing
Summary: Effective antiviral therapy can improve the long-term prognosis of HBV-related decompensated patients and achieve re-compensation in some cases. This study analyzed the clinical outcomes of 196 patients with HBV-related first decompensated cirrhosis of ascites treated with nucleos(t)ide analogue and found that ascites regression and re-compensation were observed after NUC treatment. The level of serum ALT and HBV DNA at baseline were identified as risk factors for ascites re-compensation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Gustaf E. Rydell, Kasthuri Prakash, Simon B. Larsson, Catarina Skoglund, Johan Ringlander, Maria Andersson, Maria Castedal, Helene Norder, Magnus Lindh
Summary: Hepatitis B virus (HBV) RNA levels showed significant variation between different tissue samples, with up to a 1000-fold difference. When replication was high, core RNA and S RNA levels were similar, indicating transcription from covalently closed circular DNA (cccDNA). In patients with medium-high or low replication, enhanced expression of S RNA relative to cccDNA and core RNA suggested that HBsAg can be primarily expressed from integrated HBV DNA.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Medical Laboratory Technology
Qianxia Wu, Weilin Mao
Summary: This study found that elevated MHR is associated with increased mortality rate in HBV-DeCi patients, and MHR can be an independent risk factor for mortality with significant predictive value.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Microbiology
Ranxi Li, Xinzhu Yi, Junhao Yang, Zhou Zhu, Yifei Wang, Xiaomin Liu, Xili Huang, Yu Wan, Xihua Fu, Wensheng Shu, Wenjie Zhang, Zhang Wang
Summary: The gut microbiome is associated with HBV-induced liver disease, with specific microbial signatures identified at each disease stage. These microbial taxonomy may serve as non-invasive biomarkers for monitoring disease progression and potential microbiome-based therapies.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Nutrition & Dietetics
Kurt Gruengreiff, Thomas Gottstein, Dirk Reinhold, Claudia A. Blindauer
Summary: Decompensated liver cirrhosis has a poor prognosis, and albumin therapy can counteract various complications, with a close relationship between albumin and zinc. Therefore, albumin and zinc play important roles in the treatment of liver cirrhosis.
Article
Medicine, General & Internal
Byungyoon Yun, Sang Hoon Ahn, Juyeon Oh, Jin-Ha Yoon, Beom Kyung Kim
Summary: This study aimed to compare the postoperative recurrence of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV)-infected HCC who received antiviral therapy (AVT) compared to those who did not. The results showed that the recurrence rates of HCC were similar between AVT users and non-users with detectable serum HBV-DNA, regardless of the presence of liver cirrhosis. Therefore, initiating AVT based on detectable serum HBV-DNA can provide a similar risk of postoperative HCC recurrence.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Ashwani K. Singal, Yong-Fang Kuo
Summary: This study compared the waitlist and post-transplant outcomes of liver transplantation alone (LTA) and simultaneous liver kidney (SLK) listings. It found that SLK patients had lower mortality on the waitlist and higher survival rates after transplantation. Therefore, the kidney function of patients should be taken into consideration when choosing the transplantation method.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Nutrition & Dietetics
Gemma Llibre-Nieto, Alba Lira, Mercedes Vergara, Meritxell Casas, Cristina Sole, Jose Ferrusquia-Acosta, Valenti Puig-Divi, Laia Grau-Lopez, Josep Maria Barradas, Marta Sola, Mireia Miquel, Jordi Sanchez-Delgado
Summary: Chronic alcohol consumption is associated with both chronic pancreatitis and liver cirrhosis. The prevalence of chronic pancreatitis and low fecal elastase in patients with decompensated liver disease was investigated in this study. The results showed that a significant proportion of patients had exocrine pancreatic insufficiency and chronic pancreatitis.
Review
Biochemistry & Molecular Biology
Adrian Boicean, Victoria Birlutiu, Cristian Ichim, Olga Brusnic, Danusia Maria Onisor, Amedeo Amedei, Ryota Niikura
Summary: Imbalances in the gut microbiota play a crucial role in the development of liver diseases, and fecal microbiota transplantation has shown promise as an effective treatment for chronic liver diseases and cirrhosis.
Article
Medicine, General & Internal
Pei-Yuan Su, Yang-Yuan Chen, Jun-Hung Lai, Hung-Ming Chen, Chih-Ta Yao, I-Ling Liu, Ya-Huei Zeng, Siou-Ping Huang, Yu-Chun Hsu, Shun-Sheng Wu, Fu-Yuan Siao, Hsu-Heng Yen
Summary: This study evaluated the safety and efficacy of glecaprevir/pibrentasvir in patients with compensated cirrhosis in a real-world setting. The treatment regimen was found to be highly effective and well tolerated among these patients.
JOURNAL OF CLINICAL MEDICINE
(2021)