Journal
MICROBIAL DRUG RESISTANCE
Volume 24, Issue 7, Pages 1054-1066Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/mdr.2018.0154
Keywords
antimicrobial resistance; Escherichia coli; extended-spectrum beta-lactamese-producing Escherichia coli; longitudinal study; pig production; pork
Funding
- 90th Year Anniversary Ratchdapisek Somphot Endowment Fund, Chulalongkorn University, Center of Excellence in Emerging and Re-emerging Infectious Diseases in Animals (EIDAs)
- Research and Researcher for Industrials Funds [PHD5610005]
- Huvepharma (Thailand) Ltd
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The aims of this study were (i) to evaluate whether routine in-feed antimicrobial use in pigs or not resulted in differences in antimicrobial resistance (AMR) E. coli at different pig producing stages, and (ii) to determine whether resistant strains were presented in pig meat postslaughter. A total of 300 commensal E. coli isolates were obtained and examined for antibiograms, AMR genes, plasmid replicons, and molecular types. The isolates were from two farms either using (A) or not using in-feed antimicrobials (NA), sampled four times during the production cycle and once postslaughter. E. coli resistant to aminoglycosides containing aadA1, aadA2, and aadB and extended-spectrum beta-lactamase-producing (ESBLP) E. coli containing bla(CTX-M-1) were significantly increased in the nursery and growing periods in farm A compared to farm NA. IncI1-I and IncHI2 were common in the nursery period and were shown to transfer bla(CTX-M) genes by conjugation. ST10 was the most common type only found in live pigs. ST604, ST877, ST1209, and ST2798 ESBLP were found only in live pigs, whereas ST72, ST302, and ST402 ESBLP were found in pig meat.
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