Article
Chemistry, Multidisciplinary
Bei Ran, Yuyu Yuan, Wenxi Xia, Mingle Li, Qichao Yao, Zuokai Wang, Lili Wang, Xiaoyu Li, Yongping Xu, Xiaojun Peng
Summary: This study introduces a unique cationic photosensitizer (NB) and bacteriophage (ABP)-based photodynamic antimicrobial agent (APNB) for precise bacterial eradication and biofilm ablation. The APNB demonstrates excellent reactive oxygen species (ROS)-production ability and specific binding to pathogenic microorganisms provided by bacteriophages. It shows potential for fighting against multidrug-resistant bacteria and biofilm ablation in practice.
Article
Infectious Diseases
Sirijan Santajit, Phuangthip Bhoopong, Thida Kong-Ngoen, Witawat Tunyong, Dararat Horpet, Wanfudhla Paehoh-ele, Tasneem Zahedeng, Pornpan Pumirat, Nitat Sookrung, Woranich Hinthong, Nitaya Indrawattana
Summary: This study characterized the genetic traits of biofilm-forming carbapenem-resistant A. baumannii clinical isolates in a tertiary care hospital. The prevalence of biofilm-producing A. baumannii isolates was determined and their association with biofilm-related and antibiotic resistance-associated genotypes was investigated. The predominance of biofilm-producing CRAB isolates identified in this study is concerning, and understanding the risk factors could help control the selection and spread of A. baumannii in hospitals, thereby improving patient care quality.
Article
Public, Environmental & Occupational Health
Meijie Jiang, Xia Chen, Shuang Liu, Zhijun Zhang, Ning Li, Chao Dong, Ling Zhang, Haiyan Wu, Shuping Zhao
Summary: The study found that there was no significant change in the antibiotic-resistant and carbapenemase-resistant genes of 295 MDR A. baumannii isolates in the hospital over the past 12 years, and most isolates had a relatively close genetic relationship. The detection rates of carbapenemase-resistant genes bla(OXA-23), bla(TEM-1), and bla(OXA-66) were high, and the most common sequence types were ST208 and ST369.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Microbiology
Jacinda C. Abdul-Mutakabbir, Logan Nguyen, Philip T. Maassen, Kyle C. Stamper, Razieh Kebriaei, Keith S. Kaye, Mariana Castanheira, Michael J. Rybak
Summary: Cefiderocol, a novel siderophore cephalosporin, shows potent activity against multidrug-resistant Acinetobacter baumannii, with lower MIC values compared to other Gram-negative agents. Studies indicate synergistic effects when combined with other antibiotics, and beta-lactamase inhibitors increase susceptibility to CFDC in MDR A. baumannii isolates.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Genetics & Heredity
Valeria Mateo-Estrada, Ciara Tyrrell, Benjamin A. Evans, Alejandro Aguilar-Vera, David Drissner, Santiago Castillo-Ramirez, Fiona Walsh
Summary: This study analyzed Acinetobacter baumannii strains and found significant differences between grass isolates and human-animal isolates. Additionally, grass isolates had fewer antibiotic resistance genes and were not resistant to the antibiotics tested. The results suggest that genomic epidemiology and surveillance of A. baumannii should take into account environmental factors beyond hospital settings.
MICROBIAL GENOMICS
(2023)
Article
Pediatrics
Capan Konca, Mehmet Tekin, Mehmet Geyik
Summary: The study investigated the antimicrobial resistance patterns of multidrug-resistant Acinetobacter baumannii in pediatric intensive care unit patients. Results showed that many previously effective drugs have lost their effectiveness against MDRAB, with colistin remaining as the only effective drug. New drugs and treatment protocols are urgently needed to combat MDRAB.
INDIAN JOURNAL OF PEDIATRICS
(2021)
Article
Microbiology
Yi Huang, Md Roushan Ali, Wei Li, Wanying Wang, Yuanyuan Dai, Huaiwei Lu, Zhien He, Yujie Li, Baolin Sun
Summary: This study focused on Acinetobacter baumannii, a major health threat, and specifically investigated the ST369 strain prevalent in China. The researchers identified potential mutations that could impact bacterial virulence and resistance, providing a foundation for further research on clinical isolates harboring similar mutations.
Review
Medicine, General & Internal
Guido Granata, Fabrizio Taglietti, Francesco Schiavone, Nicola Petrosillo
Summary: This study assessed the efficacy and safety of a novel antibiotic, durlobactam, in the treatment of multidrug-resistant A. baumannii infections. Sixteen studies met the inclusion criteria, and it was found that durlobactam is effective when used in combination with sulbactam against A. baumannii. Further clinical trials are needed to confirm the potential of this combination therapy for treating infections caused by multidrug-resistant A. baumannii.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Medicinal
E. H. T. Thulshan Jayathilaka, Dinusha C. Rajapaksha, Chamilani Nikapitiya, Joeun Lee, Mahanama De Zoysa, Ilson Whang
Summary: Octoprohibitin, a synthetic antimicrobial peptide derived from the prohibitin-2 gene of Octopus minor, showed significant activity against multidrug resistant Acinetobacter baumannii, inhibiting both bacterial growth and biofilm formation.
Article
Microbiology
Valeria Mateo-Estrada, Jose Luis Fernandez-Vazquez, Julia Moreno-Manjon, Ismael L. Hernandez-Gonzalez, Eduardo Rodriguez-Noriega, Rayo Morfin-Otero, Maria Dolores Alcantar-Curiel, Santiago Castillo-Ramirez
Summary: This study used whole-genome sequencing to uncover the transmission dynamics of extensive and multidrug-resistant A. baumannii in a tertiary hospital over a decade, showing that accessory genome variation can be a powerful tool for conducting genomic epidemiology.
Article
Microbiology
Sana Azaiez, Marisa Haenni, Asma Ben Cheikh, Mohamed Sahbi Chalbi, Aziza Messaoudi, Lamia Tilouch, Sana Bahri, Antoine Drapeau, Estelle Saras, Mariem Mtibaa, Rania Zouaoui, Houyem Said, Jean-Yves Madec, Agnese Lupo, Wejdene Mansour
Summary: Carbapenem-resistant Acinetobacter baumannii (CRAB) strains spread rapidly in hospitals, causing severe and difficult-to-treat infections. A study found a high occurrence of CRAB in the intensive care units (ICUs) of Sahloul University hospital in Tunisia. Surfaces of items and medical personnel in the ICUs were found to be potential reservoirs for CRAB strains. Patients in the ICUs were infected with CRAB strains closely related to those found in the hospital environment. Urgent hygiene measures are needed to prevent further spread of CRAB and protect the health of patients and personnel in the ICUs.
Article
Immunology
Xiaobo Li, Yanqing Song, Lina Wang, Guangbo Kang, Ping Wang, Huabing Yin, He Huang
Summary: Berberine hydrochloride (BBH) can enhance the susceptibility of multidrug-resistant Acinetobacter baumannii to antibiotics, even reversing their resistance, making it a potential promising therapeutic adjuvant against MDR strains.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Microbiology
Andrey Shelenkov, Vasiliy Akimkin, Yulia Mikhaylova
Summary: Acinetobacter baumannii is a highly successful hospital pathogen with exceptional survival skills and rapid antibiotic resistance acquisition. The global spread of A. baumannii is driven by high-risk international clones (ICs), but determining IC assignment based on genomic sequences can be challenging. This review focuses on typing tools for IC determination, provides data for easily identifying IC assignment, discusses the history and spread of nine known ICs, and investigates their representation in public databases. The possible emergence of a new IC, IC10, is also discussed.
Review
Immunology
Ayman Elbehiry, Eman Marzouk, Ihab Moussa, Yazeed Mushayt, Ahmad Abdullah Algarni, Osama Ali Alrashed, Khalid Saad Alghamdi, Naif Ahmed Almutairi, Sulaiman Abdulaziz Anagreyyah, Anwar Alzahrani, Abdulaziz M. Almuzaini, Feras Alzaben, Meshal Abdullah Alotaibi, Suha Abdulaziz Anjiria, Akram Abu-Okail, Adil Abalkhail
Summary: Healthcare providers worldwide are increasingly concerned about the prevalence of multidrug-resistant Acinetobacter baumannii (A. baumannii). This bacterial pathogen is responsible for some of the most severe hospital-acquired infections, particularly in intensive care units (ICUs). The rise in multidrug-resistant A. baumannii has been attributed to the overuse of antimicrobial drugs and inadequate infection control measures. Infections caused by this pathogen are associated with prolonged hospitalization and ICU stays, leading to increased morbidity and mortality.
Article
Microbiology
Carina Mueller, Sandra Reuter, Julia Wille, Kyriaki Xanthopoulou, Danuta Stefanik, Hajo Grundmann, Paul G. Higgins, Harald Seifert
Summary: This study conducted molecular epidemiology and global distribution research on 313 carbapenem-resistant Acinetobacter baumannii isolated from 114 study centers in 47 countries. The results revealed a wide variation in the distribution of carbapenemase encoding genes among different geographical regions.
