Journal
MICROBIAL CELL FACTORIES
Volume 11, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1475-2859-11-142
Keywords
Biocatalysis; Bioremediation; Carboxylic acid; Gene expression; Immobilization; Nitrilase; Nitrile; Purification; Strain screening; Surface modification
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Funding
- National High Technology Research and Development Program of China [2011AA02A211]
- Fundamental Research Funds for the Central Universities [JUSRP111A51]
- Research and Innovation Project for College Graduates of Jiangsu Province [CXLX12_0731]
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Over the past decades, nitrilases have drawn considerable attention because of their application in nitrile degradation as prominent biocatalysts. Nitrilases are derived from bacteria, filamentous fungi, yeasts, and plants. In-depth investigations on their natural sources function mechanisms, enzyme structure, screening pathways, and biocatalytic properties have been conducted. Moreover, the immobilization, purification, gene cloning and modifications of nitrilase have been dwelt upon. Some nitrilases are used commercially as biofactories for carboxylic acids production, waste treatment, and surface modification. This critical review summarizes the current status of nitrilase research, and discusses a number of challenges and significant attempts in its further development. Nitrilase is a significant and promising biocatalyst for catalytic applications.
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