Journal
MICROBES AND INFECTION
Volume 16, Issue 11, Pages 954-961Publisher
ELSEVIER
DOI: 10.1016/j.micinf.2014.09.005
Keywords
ETEC; Paneth cell; Innate immunity; NF-kappa B; MAPK
Categories
Funding
- Hunan Provincial Natural Science Foundation of China [13JJ2034]
- Chinese Academy of Sciences Visiting Professorships for Senior International Scientists [2013T1S0010]
- Strategical scientific and technological research projects of emerging industries in Hunan Province [2011GK4061]
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Enterotoxigenic Escherichia coli (ETEC) is an important cause of human and porcine morbidity and mortality. The current study was conducted to identify intestinal immunity that is altered in a mouse model of ETEC infection. Innate immune responses and inflammation were analyzed. The activation of signal transduction pathways, including toll like receptor 4 (TLR-4)-nuclear factor kappa B (NF-kappa B) and mitogen-activated protein kinases (MAPK), was analyzed using immunoblotting and PCR array analyses. We found that ETEC infection promoted the expression of pro-inflammatory cytokines through the activation of the NF-kappa B and MAPK pathways. Meanwhile, ETEC infection affected sIgA transportation and Paneth cell function. These data improve our understanding of how ETEC causes disease in animals. (C) 2014 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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