Journal
MICROBES AND INFECTION
Volume 15, Issue 14-15, Pages 1017-1025Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2013.10.010
Keywords
Ehrlichia; Rickettsia; Obligate intracellular; Bacterial invasion; Rab GTPase; Nutritional virulence
Categories
Funding
- NIH/NIAID [2R56 AI067283]
- NIH-NINDS Center core grant [5P30NS047463]
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Anaplasma phagocytophilum invades neutrophils to cause the emerging infection, human granulocytic anaplasmosis. Here, we provide a focused review of the A. phagocytophilum invasin-host cell receptor interactions that promote bacterial entry and the degradative and membrane traffic pathways that the organism exploits to route nutrients to the organelle in which it resides. Because its obligatory intracellular nature hinders knock out-complementation approaches, we also discuss the current methods used to study A. phagocytophilum gene function and the potential benefit of applying novel tools that have advanced studies of other obligate intracellular bacterial pathogens. (C) 2013 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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