Journal
MICROBES AND INFECTION
Volume 15, Issue 1, Pages 11-17Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2012.10.012
Keywords
p53; Inflammation; Insulin; Senescence
Categories
Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Uehara Memorial Foundation
- Daiichi-Sankyo Foundation of Life Science
- NOVARTIS Foundation for the Promotion Science
- Japan Diabetes Foundation
- Mitsui Life Social Welfare Foundation
- Naito Foundation
- Japanese Society of Anti-aging Medicine, Life Science Foundation of Japan
- Mitsubishi Pharma Research Foundation
- Takeda Science Foundation
- Grants-in-Aid for Scientific Research [23659411] Funding Source: KAKEN
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Adipose tissue inflammation induces systemic insulin resistance in persons with obesity and heart failure, and has a crucial role in the progression of these diseases. Chronic inflammatory processes share a common mechanism in which increased production of reactive oxygen species activates p53 and NF-kappa B signaling, leading to up-regulation of pro-inflammatory cytokine expression and impairment of glucose metabolism. Since inhibition of these processes could slow the progression of various diseases, targeting adipose inflammation has the potential to become a new therapeutic approach for diabetes and heart failure. (C) 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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