Journal
MICROBES AND INFECTION
Volume 14, Issue 11, Pages 916-921Publisher
ELSEVIER
DOI: 10.1016/j.micinf.2012.04.015
Keywords
Actinomyces viscosus; Inflammation; Lipoprotein; Toll-like receptor 2
Categories
Funding
- Private University High Technology Research Center [S1001010]
- [21791796]
- [22592048]
- Grants-in-Aid for Scientific Research [21791796] Funding Source: KAKEN
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Actinomyces viscosus has been suggested to be associated with periodontal disease. However, the pathogenicity of this bacterium is not known. In this study, we examined inflammation-inducing activity by A. viscosus. Whole cells and a lipophilic fraction of A. viscosus ATCC19246 induced production of interleukin-8 and tumor necrosis factor alpha from both human oral epithelial cells and human monocytoid cells. This cytokine production was blocked by lipoprotein lipase treatment of the lipophilic fraction. In addition, anti-Toll-like receptor 2 antibody blocked the cytokine production. These results suggest that lipoprotein of A. viscosus triggers inflammatory responses in periodontitis by activation of Toll-like receptor 2. (C) 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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