Article
Materials Science, Multidisciplinary
Wei Shi, Qingyuan Li, Yunpeng Zhang, Kai Liu, Xin Huang, Xueli Yang, Yang Ran, Yifan Li, Yunlong Guo, Yunqi Liu
Summary: Research on aqueous solution sensors is highly demanded for biological sensing applications. This study introduces an approach to enhance the affinity of organic field-effect transistors (OFETs) to aqueous solutions by incorporating amphiphilic molecules in the hydrophobic semiconductor. The modified OFET demonstrates the ability to detect glucose solutions in the human blood range and achieve selective detection of various aqueous solutions. The sensing performance can be tuned by adjusting the composition of the amphiphilic molecules and introducing dielectric materials.
APPLIED MATERIALS TODAY
(2022)
Review
Engineering, Electrical & Electronic
Sharmistha Samota, Reetu Rani, Suvankar Chakraverty, Anupama Kaushik
Summary: This review provides an overview of conventional methods and recent advances in biosensing techniques for bacterial detection, with a focus on FET based biosensors. The application of different nanomaterials in fabricating Bio-FETs for bacterial detection is discussed, along with the potential use of new materials such as oxide perovskites.
MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING
(2022)
Article
Chemistry, Analytical
Panagiotis Mougkogiannis, Michael Turner, Krishna Persaud
Summary: Low power gas sensors based on organic field effect transistors fabricated in bottom-gate bottom-contact configuration show high sensitivity and selectivity towards alkylamines and ammonia, with low detection limits. A model based on the Antoine equation allows for the empirical prediction of sensor sensitivity and selectivity to various analytes.
Article
Engineering, Electrical & Electronic
Shokoofeh Sheibani, Adrian M. Ionescu, Parviz Norouzi
Summary: This research introduces a label-free fluoxetine sensor based on EGFET, which can accurately detect and measure the concentration of fluoxetine. The sensor performs well in different ionic strengths of the matrix solution and exhibits selectivity. In addition, the sensor has a very low detection limit and has been successfully applied to assay citalopram in its pharmaceutical formulation.
IEEE SENSORS JOURNAL
(2022)
Article
Engineering, Electrical & Electronic
Sobia Nisar, Misbah Shahzadi, Zafar Shahzad, Deok-kee Kim, Ghulam Dastgeer, Ahmad Irfan
Summary: Effective biosensors based on 2D field-effect transistors (FETs) composed of atomically thin semiconducting materials have been developed for prompt and label-free sensing applications. This study presents a biosensing system utilizing a MoTe2-based FET for the detection of streptavidin protein. The biosensor's dynamic behavior in detecting different concentrations of streptavidin was investigated. These 2D-FET biosensors have the potential to detect target DNA and various proteins, including the spike protein associated with Covid-19.
ACS APPLIED ELECTRONIC MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jinbiao Ma, Manman Du, Can Wang, Xinwu Xie, Hao Wang, Tie Li, Shixing Chen, Lixia Zhang, Shun Mao, Xiaohong Zhou, Min Wu
Summary: The silicon nanowire field-effect transistor (SiNW-FET) biosensor shows promising prospects in TB detection, with high sensitivity and a broad linear range. By optimizing the surface functional parameters, it can rapidly distinguish between normal individuals and TB patients in untreated sputum, greatly reducing TB detection time.
Article
Nanoscience & Nanotechnology
Wenting Shao, Michael R. Shurin, Sarah E. Wheeler, Xiaoyun He, Alexander Star
Summary: This study demonstrates the use of a high-purity semiconducting single-walled carbon nanotube field-effect transistor for rapid detection of SARS-CoV-2 antigens, displaying high sensitivity and specificity.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Analytical
Yangyang Zhu, Yiqun Zhang, Jiajia Yu, Chengren Zhou, Chaojie Yang, Lu Wang, Li Wang, Libo Ma, Li Juan Wang
Summary: A facile strategy was proposed to optimize the growth of organic field effect transistors by regulating the thickness of vanadyl-phthalocyanine films and carrying out thermal annealing. The resulting sensors exhibit multi-parameter response to humidity and nitrogen dioxide gas, with high sensitivity and repeatability.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Plant Sciences
Rachel J. Rattner, Kris E. Godfrey, Subhas Hajeri, Raymond K. Yokomi
Summary: In this study, a recombinase polymerase amplification (RPA) assay was developed for rapid and portable detection of Huanglongbing (HLB), a destructive citrus disease. The assay, which does not require DNA purification, allows for real-time detection within 8 minutes. The sensitivity and specificity of the RPA assay were comparable to the standard method, quantitative polymerase chain reaction (qPCR). The assay can be used in the field and accurately distinguish similar disease symptoms caused by different pathogens, aiding in the control of HLB spread.
Article
Plant Sciences
Qiang Wang, Ming Qin, Jeffrey J. Coleman, Wenjing Shang, Xiaoping Hu
Summary: Verticillium wilt, caused by Verticillium dahliae, is a significant soilborne plant disease worldwide. In this study, a detection method using CRISPR/Cas12a and RPA technologies was developed for accurate and rapid detection of V. dahliae. The detection system had a lower detection limit of approximately 10 copies of genomic DNA per reaction and could detect as little as one microsclerotium per gram of soil. This study expands the application of CRISPR/Cas12a nucleic acid detection to soilborne crop diseases and contributes to the development of field-deployable diagnostic tools.
Article
Nanoscience & Nanotechnology
Riho Mitobe, Yui Sasaki, Wei Tang, Qi Zhou, Xiaojun Lyu, Kohei Ohshiro, Masao Kamiko, Tsuyoshi Minami
Summary: An organic field-effect transistor-based chemical sensor has been developed for detecting multiple oxyanions using pattern recognition techniques. The sensor has shown success in qualitative detection of 13 oxyanions and quantification of hydrogen monophosphate in human blood serum with low errors. This demonstrates the potential for the sensor to be used as a practical sensing platform for medical assays through a combination of OFET functionalization and pattern recognition methods.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Physical
Tomas Vincze, Michal Micjan, Juraj Nevrela, Martin Donoval, Martin Weis
Summary: Organic field-effect transistors are considered the future direction for advanced photodetectors due to their unique absorption characteristics, low-cost fabrication, or compatibility with flexible substrates. However, the response time of organic phototransistors still needs to be improved.
Article
Engineering, Electrical & Electronic
Sumit Sharma, Akshay Moudgil, Sanjay Singh, Prashant Mishra, Samaresh Das
Summary: This article demonstrates an ultrasensitive field-effect transistor (FET) for the detection of hydrogen sulfide (H2S) in human blood or plasma. The biosensor utilizes multiple layers of MoSe2 as the channel material and achieves detection of H2S at concentrations as low as 1 μM. With a wide linear dynamic range and low detection limit, this FET device is suitable for quick and real-time detection of H2S in plasma.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2023)
Article
Chemistry, Analytical
Pin-Hsuan Chen, Chih-Cheng Huang, Chia-Che Wu, Po-Hsuan Chen, Adarsh Tripathi, Yu-Lin Wang
Summary: Facing the insufficient capacity of diagnostic testing in controlling the spread of COVID-19, a rapid screening tool is proposed in this study. The saliva-based COVID-19 antigen test using the electrical double layer-gated field-effect transistor biosensor shows high specificity and portability.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Nanoscience & Nanotechnology
B. Li, H. Huang
Summary: A furan ring is often incorporated into n-conjugated molecules, either by fusion with a carbon n-system or as an n-spacer, leading to significant changes in the photophysical, electrochemical, and charge transport properties. Furan semiconductors, as a emerging class of organic semiconductors, have attracted wide attention due to their remarkable features such as high solubility, photoluminescent quantum efficiency, and carrier mobility. Notably, both p-type and n-type furan semiconductors show great potential for applications in organic field-effect transistors (OFETs), with the highest mobility of 7.7 cm2/Vs achieved for a quinoidal oligofuran. In this review, we summarize the development of furan semiconductors and their applications in OFETs, providing a perspective on these materials.
MATERIALS TODAY NANO
(2023)
Article
Cardiac & Cardiovascular Systems
Sandeep Jha, Rickard Zeijlon, Israa Enabtawi, Aaron Shekkha Espinosa, Jasmina Chamat, Elmir Omerovic, Bjorn Redfors
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2020)
Article
Chemistry, Analytical
Tanu Bhardwaj, Priyanka Dalal, Anurag S. Rathore, Sandeep Kumar Jha
SENSORS AND ACTUATORS B-CHEMICAL
(2020)
Article
Cardiac & Cardiovascular Systems
Rickard Zeijlon, Jasmina Chamat, Israa Enabtawi, Sandeep Jha, Mohammed Munir Mohammed, Johan Wagerman, Vina Le, Aaron Shekka Espinosa, Erik Nyman, Elmir Omerovic, Bjorn Redfors
Summary: In this study, the risk of LTVA or death within 72 hours of admission was significantly lower in patients with TS compared to patients with anterior and non-anterior STEMI, despite similar or greater risks of acute heart failure and similar risk of cardiogenic shock.
Article
Electrochemistry
Tarun Kumar Dhiman, G. B. V. S. Lakshmi, Kashyap Dave, Appan Roychoudhury, Nishu Dalal, Sandeep K. Jha, Anil Kumar, Ki-Ho Han, Pratima R. Solanki
Summary: The study utilized an electrochemical microfluidic biosensing platform to detect FU-B1 mycotoxin in food products, achieving rapid, label-free, and highly sensitive detection using a silver-ceria nanocomposite.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2021)
Article
Cardiac & Cardiovascular Systems
Bjorn Redfors, Sandeep Jha, Sigurdur Thorleifsson, Tomas Jernberg, Oskar Angeras, Ole Frobert, Petur Petursson, Per Tornvall, Giovanna Sarno, Christina Ekenback, Annika Ravn-Fisher, Shams Y-Hassan, Alexander R. Lyon, Stefan James, David Erlinge, Elmir Omerovic
Summary: Takotsubo syndrome (TS) has a lower short-term mortality risk compared to ST-segment-elevation myocardial infarction (STEMI) but higher than non-STEMI (NSTEMI). TS has a similar risk of acute heart failure to STEMI but a lower risk of cardiogenic shock. Smoking is an independent predictor of mortality in TS patients compared to those with STEMI and NSTEMI.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Medical Laboratory Technology
Ola Hammarsten, Pontus Ljungqvist, Bjorn Redfors, Mathias Wernbom, Hannes Widing, Bertil Lindahl, Sabin Salahuddin, Ruwayda Sammantar, Sandeep Jha, Annica Ravn-Fischer, Magnus Brink, Magnus Gisslen
Summary: Although cTnT and cTnI are expressed to similar amount in cardiac tissue, cTnI often reach ten-times higher peak levels compared to cTnT in patients with myocardial necrosis such as in acute myocardial infarction (MI). In contrast, levels of cTnI were lower than cTnT in COVID-19 patients, indicating that the release of cardiac troponin has a different cause in COVID-19 patients.
CLINICA CHIMICA ACTA
(2022)
Article
Electrochemistry
Tanu Bhardwaj, Sandeep Kumar Jha
Summary: In this study, an aptamer-based PDMS/glass microfluidic chip biosensor was developed for the detection of Lucentis in fermenters. The chip demonstrated better detection limits and linear range compared to the HPLC-based method. Real sample analysis showed a significant correlation between the microchip biosensor and HPLC-based detection method. The chip is miniaturized, selective, specific, interference-free, label-free, rapid, and reusable, making it suitable for on-line PAT monitoring in Lucentis production.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Nanoscience & Nanotechnology
Avinash Kumar Singh, Tarun Kumar Dhiman, G. B. V. S. Lakshmi, Rishi Raj, Sandeep Kumar Jha, Pratima R. Solanki
Summary: In this study, a microfluidic electrochemical biosensor based on tri-manganese tetroxide nanoparticles was developed for the detection of aflatoxin B1. The sensor exhibited high sensitivity, low detection limit, and good recovery in spiked samples.
Article
Cardiac & Cardiovascular Systems
Rickard Zeijlon, Peter Hallgren, Vina Le, Jasmina Chamat, Johan Wagerman, Israa Enabtawi, Araz Rawshani, Sten Unenge, Sandeep Jha, Elmir Omerovic, Bjorn Redfors
Summary: This study aimed to determine if abnormal admission electrocardiogram (ECG) predicts the need for intensive care treatment or in-hospital death within 30 days in patients hospitalized for COVID-19. The study found that abnormal admission ECG was associated with an increased risk of treatment at intensive care unit or in-hospital death within 30 days and could be considered a high-risk criterion in patients hospitalized for COVID-19.
JOURNAL OF ELECTROCARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Aaron Shekka Espinosa, Shafaat Hussain, Amin Al-Awar, Sandeep Jha, Ahmed Elmahdy, Mana Kalani, Yalda Kakei, Ermir Zulfaj, Emma Aune, Angela Poller, Emanuele Bobbio, Sigurdur Thoirleifsson, Rickard Zeijlon, Thorstein Gudmundursson, Mathias Wernbom, Bertil Lindahl, Christian L. Polte, Elmir Omerovic, Ola Hammarsten, Bjorn Redfors
Summary: The study found that after brief periods of cardiac ischemia, both high-sensitive cardiac troponin I (hs-cTnI) and high-sensitive cardiac troponin T (hs-cTnT) increased similarly. However, longer periods of ischemia that caused substantial necrosis led to an increase in the hs-cTnI/hs-cTnT ratio, indicating that this ratio may be an indicator of ischemia-induced myocardial necrosis.
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2023)
Article
Cardiac & Cardiovascular Systems
Rickard Zeijlon, Jasmina Chamat, Vina Le, Johan Wagerman, Israa Enabtawi, Sandeep Jha, Mohammed Munir Mohammed, Aaron Shekka Espinosa, Oskar Angeras, Truls Ramunddal, Elmir Omerovic, Bjorn Redfors
Summary: This study compared the electrocardiograms (ECGs) of STE-TS and STEMI patients and found that the admission ECG of STE-TS was more similar to LAD STEMI and reciprocal ST depression was less common in STE-TS compared to overall STEMI. ST segment changes predicted life-threatening ventricular arrhythmia or death in STEMI but not in STE-TS.
IJC HEART & VASCULATURE
(2022)
Proceedings Paper
Computer Science, Information Systems
Bo Long, Jieping Ye, Zang Li, Huiji Gao, Sandeep Kumar Jha
PROCEEDINGS OF THE 43RD INTERNATIONAL ACM SIGIR CONFERENCE ON RESEARCH AND DEVELOPMENT IN INFORMATION RETRIEVAL (SIGIR '20)
(2020)
Article
Chemistry, Multidisciplinary
Tanu Bhardwaj, Anurag S. Rathore, Sandeep Kumar Jha
Proceedings Paper
Physics, Applied
K. P. Chandra, Sandeep Kumar Jha, A. R. Kulkarni, K. Prasad
3RD INTERNATIONAL CONFERENCE ON CONDENSED MATTER & APPLIED PHYSICS (ICC-2019)
(2020)
Article
Chemistry, Multidisciplinary
Appan Roychoudhury, Kevin Antony Francis, Jay Patel, Sandeep Kumar Jha, Suddhasatwa Basu
