Article
Chemistry, Multidisciplinary
Linlin Li, Hao Xu, Zhexin Li, Lingchen Liu, Zheng Lou, Lili Wang
Summary: By using magnetron sputtering technology, the monolithic integration of large area tellurium optoelectronic functional units is achieved. The type II heterojunction constructed by tellurium (Te) and silicon (Si) effectively separates the photogenerated carriers, prolonging the carrier lifetime and improving the photoresponse by several orders of magnitude. The tellurium/silicon (Te/Si) heterojunction photodetector exhibits excellent detectivity and ultra-fast turn-on time. An imaging array (20 x 20 pixels) based on the Te/Si heterojunction is demonstrated and high-contrast photoelectric imaging is achieved. Compared to Si arrays, the Te/Si array significantly enhances the efficiency and accuracy of subsequent processing tasks when electronic pictures are applied to simulate an artificial vision system using artificial neural networks (ANN).
Article
Chemistry, Multidisciplinary
Siti Fatimah Abd Rahman, Nor Azah Yusof, Mohd Khairuddin Md Arshad, Uda Hashim, Mohammad Nuzaihan Md Nor, Mohd Nizar Hamidon
Summary: A highly sensitive silicon nanowire-based sensor device was developed using electron beam lithography integrated with CMOS technology. The device showed good alignment and linearity for pH sensing, and could also be used for detecting specific ssDNA molecules.
Article
Optics
Shanglin Yang, Hao Jia, Jiaqi Niu, Xin Fu, Lin Yang
Summary: In this study, we designed a CMOS-compatible ultra-compact multimode waveguide bend, which can simultaneously transmit signals of TE0, TE1, and TE2 modes with high efficiency and has low insertion loss and inter-mode crosstalk.
OPTICS COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Yuzhi Xu, Yanfei Zhang, Huihui Yang, Wen Yin, Leli Zeng, Shuo Fang, Si-Yang Liu, Zong Dai, Xiaoyong Zou, Yihang Pan
Summary: Researchers have developed a facile method to synthesize two-dimensional coordination polymer nanosheets for nucleic acid detection. These nanosheets can be used as nanosensors with low detection limits and can also deliver nucleic acids.
CHINESE CHEMICAL LETTERS
(2022)
Article
Optics
Ranjan Das, Yanran Xie, Henry Frankis, Keru Chen, Hermann Rufenacht, Guillaume Lamontagne, Jonathan D. B. Bradley, Andrew P. Knights
Summary: This study reports a novel gain-enabled delay readout system using a tunable optical carrier, low-frequency RF signal, and CMOS-compatible photodetectors suitable for silicon photonic integration. The characterization method relies on direct phase measurement of an input RF signal and extraction of the delay profile under distinct ring-bus coupling formats of a true-time delay unit.
PHOTONICS RESEARCH
(2022)
Article
Optics
Yaozu Xie, Jiaqi Li, Yanfeng Zhang, Zeru Wu, Shihao Zeng, Shuqing Lin, Zhaoyang Wu, Wenchao Zhou, Yujie Chen, Siyuan Yu
Summary: The research reports the successful generation of coherent soliton frequency combs in micro-ring resonators fabricated in deuterated silicon nitride waveguides with a loss of 0.09 dB/cm. The material preparation and fabrication process using inductance-coupled plasma chemical vapor deposition are fully CMOS-compatible, marking a significant advancement in silicon nitride photonic technologies.
PHOTONICS RESEARCH
(2022)
Article
Chemistry, Analytical
Yann Sprunger, Luca Capua, Thomas Ernst, Sylvain Barraud, Didier Locca, Adrian Ionescu, Ali Saeidi
Summary: In this paper, a novel approach utilizing silicon nanowires as high-sensitivity pH sensors is proposed. The approach works by fixing the current bias of ISFETs and monitoring the resulting drain voltage as the sensing signal. This method is highly suitable for real-time and continuous measurements of biomarkers in human biofluids, achieving exceptional accuracy in a complex matrix.
Article
Biophysics
Qilin Zhao, Yu Wang, Mengqian Zhang, Donghui Wu, Jian Sun, Xiurong Yang
Summary: A facile and sensitive method for sensing alpha-glucosidase and screening its inhibitors based on fluorescence monitoring of water-solute silicon-containing nanoparticles was proposed and demonstrated. The method showed a linear relationship and a low detection limit, and it could be applied in human serum and inhibitor screening.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Mathematics, Interdisciplinary Applications
Dahye Kim, Sunghun Kim, Sungjun Kim
Summary: This paper investigates the characteristics of bipolar and unipolar RRAM in CMOS-compatible devices, successfully demonstrating most Boolean functions and proposing solutions to represent the remaining ones that cannot be represented.
CHAOS SOLITONS & FRACTALS
(2021)
Article
Chemistry, Multidisciplinary
Maria N. Koryazhkina, Dmitry O. Filatov, Stanislav V. Tikhov, Alexey I. Belov, Dmitry A. Serov, Ruslan N. Kryukov, Sergey Yu. Zubkov, Vladislav A. Vorontsov, Dmitry A. Pavlov, Evgeny G. Gryaznov, Elena S. Orlova, Sergey A. Shchanikov, Alexey N. Mikhaylov, Sungjun Kim
Summary: The electrical characteristics and resistive switching properties of memristive devices using silicon oxide and titanium nitride as the insulator and electrode materials have been studied. The as-fabricated devices do not require electroforming, but their resistance state cannot be stored before thermal treatment. After the thermal treatment, the devices exhibit bipolar-type resistive switching with synaptic behavior, where filaments form in the insulator due to the effect of traps. These devices can be easily integrated with traditional analog-digital circuits to implement new-generation hardware neuromorphic systems.
Article
Nanoscience & Nanotechnology
Weina Zhang, Pu Liu, Guowei Yang, Hongxiang Lei
Summary: Nanowires fabricated from polylactic acid (PLA) using a direct drawing method exhibit high optical transparency, good biocompatibility, biodegradability, and flexibility. The nanowires achieved ultra-low concentration sensing of cytochrome c with a detection limit of 1.38 x 10(-17) M, much lower than other semiconductor/metal-based nanosensors. Additionally, they enable label-free, real-time monitoring of cell apoptosis and pH sensing through quantum dot doping. These results highlight the potential of PLA nanowires in multifunctional biosensing and biodetection, advancing the field of photomedicine.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Yuqi Huang, Shuhui Zhao, Wenxiu Zhang, Qiuyue Duan, Qi Yan, Hu Fu, Liang Zhong, Gang Yi
Summary: This paper introduces a multifunctional electrochemical biosensor constructed with sturdy tetrahedral tripods that enable multiple tandem reactions and ultra-sensitive detection of targets such as DNA, miRNA, and methylated DNA.
Article
Engineering, Electrical & Electronic
Jiayao Huang, Feng Ye, Qian Li
Summary: CMOS-compatible silicon-based nonlinear optical devices have advantages of lower operating powers, precise dispersion control, and extensive transparency range. In this article, we propose a cascaded soliton compression scheme on CMOS-compatible Silicon Nanophotonic Wire Waveguides in the mid-infrared region, achieving large compression factor. This research demonstrates the potential of dispersion engineering waveguides for mid-infrared low-power applications.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2022)
Article
Engineering, Electrical & Electronic
Souvaraj De, Ranjan Das, Ravendra K. Varshney, Thomas Schneider
Summary: A comprehensive analysis was conducted on the thermal crosstalk issue in silicon photonic circuits, using metal and doped silicon heaters for different waveguide configurations. By performing full-wave thermal and optical simulations, the study proposed solutions to reduce phase crosstalk and improve thermal tuning efficiency, demonstrating superior performance in thermal crosstalk over existing designs for compact silicon photonic circuits operating at high temperatures.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Thierno-Moussa Bah, Stanislav Didenko, Di Zhou, Tianqi Zhu, Hafsa Ikzibane, Stephane Monfray, Thomas Skotnicki, Emmanuel Dubois, Jean-Francois Robillard
Summary: This research reports the use of nanostructured crystalline silicon as a thermoelectric material and its integration into thermoelectric devices. By partially suppressing lattice thermal conduction through introducing pores, a trade-off between electron crystal and phonon glass was achieved. The fabricated devices, using CMOS-compatible processes, demonstrated power generation under a temperature difference and the capability to power autonomous devices.
Article
Chemistry, Multidisciplinary
Hui Lu, Jinsong Fan, Guangliu Ran, Jiang Li, Lihua Wang, Ying Zhu, Jianlei Shen, Wenkai Zhang, Jing Chen, Chunhai Fan
Summary: This study reports the functionalization of bimetallic nanoclusters Au8Ag8(C(sic)CR)(16) with triarylborane, which enhances the Lewis acidity. The structure of the nanocluster with 16 boron receptor sites is confirmed, showing increased quenching efficiency towards fluoride. The quenching mechanism of Au8Ag8 to fluoride is demonstrated via enhanced non-radiation energy dissipation.
ADVANCED MATERIALS INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Xingjie Hu, Yan Huang, Hong Zheng, Jiahui Liu, Mengmeng Liu, Mo Xie, Chunhai Fan, Nan Chen
Summary: Framework nucleic acids (FNAs) are a new type of DNA-based nanomaterials with potential applications in biosensing, bioimaging, and molecular delivery. Hierarchical DNA nanostructures composed of multiple FNAs increase drug delivery capacity and multifunctional modification. However, there are limited studies on the behavior and regulation of hierarchical FNAs in living cells, hindering their further applications.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Cuiping Mao, Shuchen Wang, Jiankai Li, Zhuowei Feng, Tong Zhang, Rui Wang, Chunhai Fan, Xingyu Jiang
Summary: DNA, as a storage medium, offers high information density but requires specialized equipment and controlled environments. We introduce a DNA microlibrary encapsulated in metal-organic frameworks (MOFs) within 10 minutes and extracted in 5 minutes using a microfluidic chip for automated and integrated DNA-based data storage. The DNA microlibrary@MOFs enhances the stability of data-encoded DNA against harsh environments and can be read out perfectly after accelerated aging, equivalent to 10-year storage under specific conditions.
Review
Chemistry, Multidisciplinary
Fei Ding, Shuangye Zhang, Qian Chen, Hao Feng, Zhilei Ge, Xiaolei Zuo, Chunhai Fan, Qian Li, Qiang Xia
Summary: Programmable nucleic acid nanotechnology allows the customization of synthetic nucleic acid nanodevices with unprecedented precision, showing potential for precise immunoengineering.
Review
Chemistry, Multidisciplinary
Xinxin Jing, Yueyue Zhang, Min Li, Xiaolei Zuo, Chunhai Fan, Junhua Zheng
Summary: Synthesis of engineered colloidal nanoparticles with delicate surface characteristics contributes to multifunctional applications. Surface engineering methods, including grafting suitable molecules or macromolecules, have been developed to improve stability and enable programmable assembly of nanoparticles.
MATERIALS HORIZONS
(2023)
Article
Chemistry, Multidisciplinary
Xiangyuan Ouyang, Yongli Wu, Linjie Guo, Le Li, Mo Zhou, Xinyi Li, Ting Liu, Yawen Ding, Huaiyu Bu, Gang Xie, Jianlei Shen, Chunhai Fan, Lihua Wang
Summary: In this study, the ordered self-assembly of CuNCs using DNA nanoribbon as the template (DNR/CuNCs) was found to improve the electrochemiluminescence (ECL) properties of CuNCs compared with individual CuNCs. The DNR/CuNCs showed a high ECL yield of 46.8% in K2S2O8, which was approximately 68 times higher than that of individual CuNCs. This strategy was also successfully applied to other ECL emitters, such as gold nanoclusters and the Ru(bpy)(3)(2+)/TPrA system. Furthermore, a DNR/CuNC-based ECL biosensor with higher sensitivity was constructed for dopamine determination, showing the potential of DNR/CuNCs as a new type of superior luminophore candidate in ECL bioanalysis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Multidisciplinary Sciences
Yinan Zhang, Xiaoyao Yin, Chengjun Cui, Kun He, Fei Wang, Jie Chao, Tao Li, Xiaolei Zuo, Ailing Li, Lihua Wang, Na Wang, Xiaochen Bo, Chunhai Fan
Summary: In this study, a model based on DNA origami frameworks (DOFs) is designed to solve the prime factorization problem. The model uses DX tiles to assemble prime and composite integers, and the result is visualized using atomic force microscopy. This DNA-based parallel computing strategy has the potential to solve complex mathematical puzzles like prime factoring.
Article
Chemistry, Multidisciplinary
Meiyuan Qi, Wenhe Ma, Qin Xu, Fei Wang, Ping Song, Sisi Jia, Xiaolei Zuo, Mingqiang Li, Guangbao Yao, Chunhai Fan
Summary: Dynamic molecular interactions in chemical reaction networks lead to complex behaviors in living systems. Programming DNA molecular reactions at molecular and nanometer scales have been achieved, but achieving programmable autonomous behavior at submicron or larger scales remains challenging. This study presents a mechanism of meta-DNA strand displacement reactions (M-SDRs) mediated solely by meta-toehold (M-toehold) using versatile submicron building blocks of meta-DNA (M-DNA). M-SDR emulates the toehold binding and branch migration processes and shows potential for programming autonomous behavior at the cellular level.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Kun Dai, Yang Xu, Yang Yang, Jianfeng Shen, Xiaoguo Liu, Xinyi Tu, Lu Yu, Xiaodong Qi, Jiang Li, Lihua Wang, Xiaolei Zuo, Yingbin Liu, Hao Yan, Chunhai Fan, Guangbao Yao
Summary: This study utilizes single-stranded RNA (ssRNA) origami as ligands for nucleic acid-sensing receptors, achieving improved stability, targeting, and immunogenicity prediction. The ssRNA self-folds into compact nanoparticles with defined shapes and exhibits resistance against degradation in cells. It can activate macrophages and neutrophils in the tumor microenvironment, leading to anti-tumoral immune response and tumor growth retardation in a mouse model. This ssRNA origami strategy provides a new solution for ligand design and biomedical applications of nucleic acid sensors.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Multidisciplinary Sciences
Yun Zhu, Xiewei Xiong, Mengyao Cao, Li Li, Chunhai Fan, Hao Pei
Summary: Freeze-thaw cycling is a simple and powerful method for high-speed DNA computing, achieving a 20-fold speed enhancement in strand displacement reactions. This acceleration is due to the use of eutectic ice phase as a medium, temporarily increasing the effective local concentration of molecules during each cycle. By leveraging this phenomenon, freeze-thaw cycling can achieve up to a remarkable 120-fold enhancement in reaction rates across various circuit sizes.
Article
Computer Science, Artificial Intelligence
Yan Zhao, Shuting Cao, Yue Wang, Fan Li, Lixuan Lin, Linjie Guo, Fei Wang, Jie Chao, Xiaolei Zuo, Ying Zhu, Lihua Wang, Jiang Li, Chunhai Fan
Summary: The environments in living cells are highly heterogeneous and compartmentalized, posing a grand challenge for the deployment of theranostic agents with spatiotemporal precision. Despite rapid advancements in creating nanodevices responsive to various cues in cellular environments, it remains difficult to control their operations based on the temporal sequence of these cues.
NATURE MACHINE INTELLIGENCE
(2023)
Review
Chemistry, Multidisciplinary
Longjiang Ding, Xiaoliang Chen, Wenhe Ma, Jiang Li, Xiaoguo Liu, Chunhai Fan, Guangbao Yao
Summary: How far we can push chemical self-assembly is one of the most important scientific questions of the century. Colloidal self-assembly is a bottom-up technique for the rational design of functional materials with desirable collective properties. The regioselective control over the formation of DNA bonds on the particle surface has enabled unprecedented complexity in colloidal self-assembly, thanks to the advances in surface chemistry and structural DNA nanotechnology. This review summarizes the recent advances in DNA-mediated regioselective surface encoding of colloids, with a focus on its introduction and its crucial role in the self-assembly of colloidal structures.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Longyi Zhu, Yiting Shen, Shengyuan Deng, Ying Wan, Jun Luo, Yan Su, Mingxu You, Chunhai Fan, Kewei Ren
Summary: Researchers have developed a synthetic DNA binder that can induce mitochondrial aggregation and fusion in living cells. This DNA binder has shown potential for repairing ROS-stressed neuron cells and can be further customized to achieve stimuli-triggered mitochondrial aggregation and fusion. The researchers believe that this new DNA regulator system can be a powerful tool for subcellular manipulation and precision therapy.
Article
Chemistry, Multidisciplinary
Yao Luo, Min Yin, Chunlan Mu, Xingjie Hu, Hui Xie, Jingyi Li, Tingting Cao, Nan Chen, Ji Wu, Chunhai Fan
Summary: This study developed a nanocomplex, Pdot-siRNA, based on semiconductor polymer dots for effective gene knockdown in female germline stem cells (FGSCs). The high fluorescence brightness of Pdots was utilized for comprehensive investigation of their cellular uptake, intracellular trafficking, and exocytosis in FGSCs. Furthermore, Pdots demonstrated excellent biocompatibility and minimal disturbance to FGSCs differentiation. The intracellular Pdots could escape from lysosomes and undergo active exocytosis, making them ideal nanocarriers for bioactive cargos. Additionally, Pdot-siRNA could penetrate into 3D ovarian organoids derived from FGSCs and down-regulate the expression levels of target genes. This study sheds light on the manipulation and medical application of FGSCs and explores the interface between theranostic nanoparticles and FGSCs for the first time.
ADVANCED MATERIALS
(2023)
Review
Biochemical Research Methods
Yuan Luo, Zhen Cao, Yifan Liu, Rong Zhang, Shijia Yang, Ning Wang, Qingyuan Shi, Jie Li, Shurong Dong, Chunhai Fan, Jianlong Zhao
Summary: DNA has shown great potential as an alternative for digital information storage but is currently hindered by high material cost, time consumption for data reading/writing, and lack of an integrated system. Microfluidics has emerged as a promising solution because of its ability to handle and process micro-scale fluid samples in a highly integrated manner. This review discusses recent efforts and advancements in applying microfluidics to DNA data storage, highlighting its potential and future directions for integration and real-life applications.
Article
Biochemical Research Methods
K. Ramki, G. Thiruppathi, Selva Kumar Ramasamy, P. Sundararaj, P. Sakthivel
Summary: A chromone-based ratiometric fluorescent probe L2 was developed for the selective detection of Hg(II) in a semiaqueous solution. The probe exhibited enhanced fluorescence in its aggregated state and even higher fluorescence when chelated with Hg(II). The probe demonstrated high sensitivity and specificity for Hg(II) detection and was successfully applied for imaging Hg(II) in a living model.
Article
Biochemical Research Methods
Qun Zhang, Rui Yang, Gang Liu, Shiyan Jiang, Jiarui Wang, Juqiang Lin, Tingyin Wang, Jing Wang, Zufang Huang
Summary: This research aims to develop a cost-effective and portable method for measuring creatinine levels using the enhanced Tyndall effect phenomenon. The method offers a promising solution for monitoring renal healthcare in resource-limited settings.
