Transition metal complexes with bioactive ligands: mechanisms for selective ligand release and applications for drug delivery

Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity

(2013) Wolfgang Kandioller et al.   CHEMICAL COMMUNICATIONS

Transition metal bioconjugates with an organometallic link between the metal and the biomolecular scaffold

(2013) Angèle Monney et al.   COORDINATION CHEMISTRY REVIEWS

Photocytotoxicity of copper(II) complexes of curcumin and N-ferrocenylmethyl-l-amino acids

(2013) Tridib K. Goswami et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cross-Bridged Cyclen or Cyclam Co(III) Complexes Containing Cytotoxic Ligands as Hypoxia-Activated Prodrugs

(2013) John Yu-Chih Chang et al.   INORGANIC CHEMISTRY

Metal–drug synergy: new ruthenium(II) complexes of ketoconazole are highly active against Leishmania major and Trypanosoma cruzi and nontoxic to human or murine normal cells

(2013) Eva Iniguez et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

A novel platinum complex of the histone deacetylase inhibitor belinostat: Rational design, development and in vitro cytotoxicity

(2013) James P. Parker et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Influence of Equatorial and Axial Carboxylato Ligands on the Kinetic Inertness of Platinum(IV) Complexes in the Presence of Ascorbate and Cysteine and within DLD-1 Cancer Cells

(2013) Catherine K. J. Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cellular Toxicity Induced by the Photorelease of a Caged Bioactive Molecule: Design of a Potential Dual-Action Ru(II) Complex

(2013) Mark A. Sgambellone et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nitric Oxide Releasing Materials Triggered by Near-Infrared Excitation Through Tissue Filters

(2013) Peter T. Burks et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Two-step activation prodrugs: transplatin mediated binding of chemotherapeutic agents to vitamin B12

(2013) Mai Thanh Quynh Tran et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Metal–Arene Complexes with Indolo[3,2-c]-quinolines: Effects of Ruthenium vs Osmium and Modifications of the Lactam Unit on Intermolecular Interactions, Anticancer Activity, Cell Cycle, and Cellular Accumulation

(2013) Lukas K. Filak et al.   ORGANOMETALLICS

Enzyme inhibition by metal complexes: concepts, strategies and applications

(2013) Kelly J. Kilpin et al.   Chemical Science

Delivery and release of curcumin by a hypoxia-activated cobalt chaperone: a XANES and FLIM study

(2013) Anna K. Renfrew et al.   Chemical Science

Targeting the DNA-topoisomerase complex in a double-strike approach with a topoisomerase inhibiting moiety and covalent DNA binder

(2012) Andrea Kurzwernhart et al.   CHEMICAL COMMUNICATIONS

Remarkable photocytotoxicity of curcumin in HeLa cells in visible light and arresting its degradation on oxovanadium(iv) complex formation

(2012) Samya Banerjee et al.   CHEMICAL COMMUNICATIONS

Enhancing the photocytotoxic potential of curcumin on terpyridyl lanthanide(iii) complex formation

(2012) Akhtar Hussain et al.   DALTON TRANSACTIONS

Organometallic anticancer agents that interfere with cellular energy processes: a subtle approach to inducing cancer cell death

(2012) Alexey A. Nazarov et al.   DALTON TRANSACTIONS

Characterization of Cobalt(III) Hydroxamic Acid Complexes Based on a Tris(2-pyridylmethyl)amine Scaffold: Reactivity toward Cysteine Methyl Ester

(2012) Mickael Alimi et al.   INORGANIC CHEMISTRY

Enhancement of Cytotoxicity by Combining Pyrenyl-Dendrimers and Arene Ruthenium Metallacages

(2012) Anaïs Pitto-Barry et al.   INORGANIC CHEMISTRY

Biological activity of ruthenium and osmium arene complexes with modified paullones in human cancer cells

(2012) Gerhard Mühlgassner et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

What do we know about the reduction of Pt(IV) pro-drugs?

(2012) Ezequiel Wexselblatt et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

New Ruthenium(II)–Letrozole Complexes as Anticancer Therapeutics

(2012) Annie Castonguay et al.   JOURNAL OF MEDICINAL CHEMISTRY

Reactions of a cytotoxic hexanuclear arene ruthenium assembly with biological ligands

(2012) Lydia E.H. Paul et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Light-Triggered Eradication of Acinetobacter baumannii by Means of NO Delivery from a Porous Material with an Entrapped Metal Nitrosyl

(2012) Brandon J. Heilman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Association of Chemotherapeutic Drugs with Dendrimer Nanocarriers: An Assessment of the Merits of Covalent Conjugation Compared to Noncovalent Encapsulation

(2012) Lisa M. Kaminskas et al.   MOLECULAR PHARMACEUTICS

Naphthalimide-Tagged Ruthenium–Arene Anticancer Complexes: Combining Coordination with Intercalation

(2012) Kelly J. Kilpin et al.   ORGANOMETALLICS

Nanoscale Metal–Organic Frameworks for Biomedical Imaging and Drug Delivery

(2011) Joseph Della Rocca et al.   ACCOUNTS OF CHEMICAL RESEARCH

N-alkylated cyclen cobalt(III) complexes of 1-(chloromethyl)-3-(5,6,7-trimethoxyindol-2-ylcarbonyl)-2,3-dihydro-1H-pyrrolo[3,2-f]quinolin-5-ol DNA alkylating agent as hypoxia-activated prodrugs

(2011) Guo-Liang Lu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Excellent Correlation between Drug Release and Portal Size in Metalla-Cage Drug-Delivery Systems

(2011) Nicolas P. E. Barry et al.   CHEMISTRY-A EUROPEAN JOURNAL

Targeted and multifunctional arene ruthenium chemotherapeutics

(2011) Gregory S. Smith et al.   DALTON TRANSACTIONS

[Ru(bpy)2(5-cyanouracil)2]2+as a Potential Light-Activated Dual-Action Therapeutic Agent

(2011) Robert N. Garner et al.   INORGANIC CHEMISTRY

A bifunctional organometallic ruthenium drug with multiple modes of inducing apoptosis

(2011) Soumya Chatterjee et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Novel trans-platinum complexes of the histone deacetylase inhibitor valproic acid; synthesis, in vitro cytotoxicity and mutagenicity

(2011) Darren M. Griffith et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Organometallic Cages as Vehicles for Intracellular Release of Photosensitizers

(2011) Frédéric Schmitt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Light Activation of a Cysteine Protease Inhibitor: Caging of a Peptidomimetic Nitrile with RuII(bpy)2

(2011) Tomasz Respondek et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Physicochemical Studies and Anticancer Potency of Ruthenium η6-p-Cymene Complexes Containing Antibacterial Quinolones

(2011) Jakob Kljun et al.   ORGANOMETALLICS

Visualising the hypoxia selectivity of cobalt(iii) prodrugs

(2011) Byung J. Kim et al.   Chemical Science

Stimuli-responsive Pd2L4metallosupramolecular cages: towards targeted cisplatin drug delivery

(2011) James E. M. Lewis et al.   Chemical Science

Photoactivated Biological Activity of Transition-Metal Complexes

(2010) Ulrich Schatzschneider   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Vitamin B12in drug delivery: breaking through the barriers to a B12bioconjugate pharmaceutical

(2010) Susan M Clardy et al.   Expert Opinion on Drug Delivery

Hypoxia-activated prodrugs in cancer therapy: progress to the clinic

(2010) William A Denny   Future Oncology

Vitamin B12 as a carrier for targeted platinum delivery: in vitro cytotoxicity and mechanistic studies

(2010) Pilar Ruiz-Sánchez et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Risedronate metal complexes potentially active against Chagas disease

(2010) Bruno Demoro et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Targeting proteins with metal complexes

(2009) Eric Meggers   CHEMICAL COMMUNICATIONS

Evidence for Drug Release from a Metalla-Cage Delivery Vector Following Cellular Internalisation

(2009) Olivier Zava et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ruthenium(II) Arene Compounds as Versatile Anticancer Agents

(2009) Anna Renfrew   CHIMIA

A fast ruthenium polypyridine cage complex photoreleases glutamate with visible or IR light in one and two photon regimes

(2009) Marcelo Salierno et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

A Gold(I) Phosphine Complex Containing a Naphthalimide Ligand Functions as a TrxR Inhibiting Antiproliferative Agent and Angiogenesis Inhibitor

(2009) Ingo Ott et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanised nanoparticles for drug delivery

(2009) Karla K. Cotí et al.   Nanoscale

Mitaplatin, a potent fusion of cisplatin and the orphan drug dichloroacetate

(2009) Shanta Dhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The “Complex-in-a-Complex” Cations [(acac)2M⊂Ru6(p-iPrC6H4Me)6(tpt)2(dhbq)3]6+: A Trojan Horse for Cancer Cells

(2008) Bruno Therrien et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Vanadium–vitamin B12 bioconjugates as potential therapeutics for treating diabetes

(2008) Riya Mukherjee et al.   CHEMICAL COMMUNICATIONS

Photoinduced CO release, cellular uptake and cytotoxicity of a tris(pyrazolyl)methane (tpm) manganese tricarbonyl complex

(2008) Johanna Niesel et al.   CHEMICAL COMMUNICATIONS

Nanoparticle therapeutics: an emerging treatment modality for cancer

(2008) Mark E. Davis et al.   NATURE REVIEWS DRUG DISCOVERY

Prodrugs: design and clinical applications

(2008) Jarkko Rautio et al.   NATURE REVIEWS DRUG DISCOVERY

Conjugated Platinum(IV)−Peptide Complexes for Targeting Angiogenic Tumor Vasculature

(2007) Sumitra Mukhopadhyay et al.   BIOCONJUGATE CHEMISTRY