Article
Chemistry, Analytical
Ying Zhou, Xiaoyu Shi, Liang Ma, Yaqin Chai, Ruo Yuan
Summary: In this study, an electrochemiluminescence (ECL) biosensor is developed for simultaneous and ultrasensitive detection of glutathione (GSH) and copper ion (Cu2+), using thiol stabilized gold nanoclusters (Au NCs) as a highly efficient ECL emitter. The study reveals that thiol-Au NCs exhibit exceptional ECL performance over amino-Au NCs due to fast electron transfer. The ECL biosensor achieves trace detection of GSH with a detection limit of 148 pM and Cu2+ with a detection limit of 91.5 fM, providing a definite direction for obtaining ultra-bright ECL metal NCs for multiple biomarker testing and expanding their application in clinical diagnosis.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Multidisciplinary
Pan Sun, Linsey M. Nowack, Wei Bu, Mrinal K. Bera, Sean Griesemer, Morgan Reik, Joshua Portner, Stuart A. Rice, Mark L. Schlossman, Binhua Lin
Summary: Thiol ligands bound to nanoparticles determine their interactions and self-assembly, with the presence of free thiols affecting the coverage on the core. X-ray scattering and MD simulations show that free thiols result in a symmetrical coating of ligands on the core, while exceeding a critical value of core-ligand coverage leads to changes in nanoparticle positioning and coverage on the surface. This highlights the crucial role of free thiols in regulating the organization of bound thiols on the core and nanoparticle interactions with the surroundings.
Article
Biochemistry & Molecular Biology
Yaru Li, Ziru Sun, Yujun Cui, Heming Zhang, Shunjie Zhang, Xinyu Wang, Shengnan Liu, Qingzhi Gao
Summary: Oxaliplatin-based chemotherapy is the current standard of care in advanced colorectal cancer, but acquired resistance limits its efficacy. In response, researchers have designed and synthesized a novel Pt(II) complex, Ph-glu-Oxa, which shows promising in vivo therapeutic potential by targeting DNA and overcoming drug resistance mechanisms.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Panlop Lormaneenopparat, Jutiporn Yukird, Nadnudda Rodthongkum, Voravee P. Hoven
Summary: This study demonstrates the use of BC/CMC/AuNPs composite hydrogel for selective adsorption of GSH, a thiol-containing biomarker of Alzheimer's disease, allowing for ultrasensitive detection required for disease diagnosis. The composite hydrogel shows excellent biocompatibility and high sensitivity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Chemistry, Inorganic & Nuclear
Nobuto Yoshinari, Naoto Kuwamura, Tatsuhiro Kojima, Takumi Konno
Summary: Thiol-containing amino acids have been extensively studied as chelating ligands, forming coordination compounds with various metal elements and exhibiting a capacity to form multinuclear structures. Recent research has demonstrated that the use of metal complexes with thiol-containing amino acids allows for the selective introduction of secondary metal ions, enabling the rational design of multinuclear and metallosupramolecular coordination compounds.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Agriculture, Multidisciplinary
Cecile Chenot, William Donck, Philippe Janssens, Sonia Collin
Summary: The contribution of polyfunctional thiols (PFTs) to lager beer flavor is significant but their origin is still unclear. Saccharomyces pastorianus yeasts were found to produce PFTs from cysteinylated and glutathionylated conjugates. Lowering wort nitrogen level and fermentation temperature improved the release efficiency of PFTs from cysteinylated conjugates, but had no effect on glutathionylated conjugates. Saaz hop and pale malt were identified as significant sources of glutathionylated conjugates.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Guoying Yao, Liang Zhao, Tao Zeng, Zhenyu Yang
Summary: Reduced-dimensional (RD) perovskites have attractive properties for optoelectronic applications. However, the coexistence of different organic ligands commonly inhibits the formation of more complex crystal structures. In this study, a mixed-dimensional (MD) perovskite single crystal containing two types of sulfide-containing ligands was reported. X-ray diffraction confirmed the structure contains layered and isolated inorganic components. The MD perovskite showed an enlarged bandgap and isotropic optical features.
Article
Chemistry, Multidisciplinary
Yan Xu, Xiao-Sheng Yan, Si-Bo Zhang, Shao-Wei Li, Ning-Shao Xia, Tao Jiang, Zhao Li, Yun-Bao Jiang
Summary: A supramolecular nanosphere with a diameter of 8.65 nm was successfully created through dynamic binding of glucose to specific ligands in an aqueous solution, demonstrating a narrow size distribution characteristic of glucose binding among tested monosaccharides.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Junmei Chen, Xiaoqing Liu, Shibo Xi, Tianyu Zhang, Zhihe Liu, Jiayi Chen, Lei Shen, Sibudjing Kawi, Lei Wang
Summary: In this study, a strategy of tailoring the surface electronic structure of an Ag catalyst via thiol ligand modification was reported to improve its intrinsic activity, selectivity, and energy efficiency for electrocatalytic CO2 reduction. The thiol-ligand modified Ag catalyst exhibited high CO selectivity and high cathodic energy efficiencies, outperforming state-of-the-art Ag-based electrocatalysts for CO2 to CO conversion.
Article
Chemistry, Medicinal
Paul Kapitza, Amelie Scherfler, Stefan Salcher, Sieghart Sopper, Monika Cziferszky, Klaus Wurst, Ronald Gust
Summary: The reactivities of gold complexes with different ligands were analyzed in cell culture medium. Complexes 6 and 7 showed significant reactions, while interactions with non-thiol containing amino acids were not detected. Complex 8 exhibited strong stability and contributed to the biological effects of complex 7. The gold(III) species were reduced by GSH and showed promising activity against drug-resistant tumors.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Osburg J. H. Chai, Zhennan Wu, Jianping Xie
Summary: In this study, a novel hydrophilic gold nanocluster model with near-neutral surface charge and pH-independent fluorescence intensity was designed, making it suitable for applications under strong acidic conditions. This type of gold nanocluster, protected by hydroxyl-thiols, is less susceptible to changes in pH compared to traditional hydrophilic thiol ligands, offering potential for diverse applications.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Rebekah N. Duffin, Liam J. Stephens, Victoria L. Blair, Lukasz Kedzierski, Philip C. Andrews
Summary: The study reveals that the new suite of organometallic complexes shows potential as selective drug candidates, but their behavior towards glutathione and trypanothione is not fully understood. At a clinically relevant pH range of 4-5, both complexes undergo rapid reduction in the presence of trypanothione or glutathione with no discernible difference. However, at a higher pH range of 6-7, they behave quite differently towards glutathione.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Chemistry, Organic
Sarah K. I. Watt, Janique G. Charlebois, Christopher N. Rowley, Jeffrey W. Keillor
Summary: Irreversible enzyme inhibitors permanently limit their target's function by covalently binding to it. The nucleophilic group targeted for reaction with the electrophilic warhead of these inhibitors is often the thiol group on cysteine residues. In this study, the mechanism of thiol addition to N-phenylchloroacetamide was investigated, revealing an early transition state for the attack by the thiolate. The reactivity of chloroacetamide was compared to acrylamides commonly used in irreversible inhibitor drugs.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Applied
Asako Narai-Kanayama, Kazuhiro Chiku, Hiroshi Ono, Takamitsu Momoi, Miho Hiwatashi-Kanno, Akiko Kobayashi, Hiroko Matsuda, Mitsuru Yoshida, Tsutomu Nakayama
Summary: Theaflavin, the polyphenol responsible for the orange color and bioactivities of black tea, can undergo autoxidation to change its color to brown under neutral and mild alkaline conditions. The presence of thiol compounds such as cysteine, glutathione, or N-acetyl cysteine can inhibit the browning of theaflavin solution and lead to a decrease in the concentrations of both theaflavin and thiol group over time. LC-MS analysis revealed the formation of novel adducts of thiol compounds. The chemical structures of theaflavin-cysteine and theaflavin-glutathione adducts were determined using NMR, showing the addition of a new cyclic structure to the theaflavin-cysteine adduct.
Article
Chemistry, Organic
Maria L. Alfieri, Alice Cariola, Lucia Panzella, Alessandra Napolitano, Marco d'Ischia, Luca Valgimigli, Orlando Crescenzi
Summary: This study provides evidence for the addition mechanism of thiol compounds to quinones and discovers an anomalous 1,6-type regiochemistry compared to the usual 1,4-nucleophilic addition. These findings would prompt a revision of the commonly accepted mechanisms for thiol-quinone conjugation and stimulate further research in this field.
JOURNAL OF ORGANIC CHEMISTRY
(2022)