Metal use in ribonucleotide reductase R2, di-iron, di-manganese and heterodinuclear—an intricate bioinorganic workaround to use different metals for the same reaction

Structural Basis for Adenosylcobalamin Activation in AdoCbl-Dependent Ribonucleotide Reductases

(2010) Karl-Magnus Larsson et al.   ACS Chemical Biology

Two Distinct Mechanisms of Inactivation of the Class Ic Ribonucleotide Reductase fromChlamydia trachomatisby Hydroxyurea: Implications for the Protein Gating of Intersubunit Electron Transfer

(2010) Wei Jiang et al.   BIOCHEMISTRY

An Active Dimanganese(III)−Tyrosyl Radical Cofactor inEscherichia coliClass Ib Ribonucleotide Reductase

(2010) Joseph A. Cotruvo et al.   BIOCHEMISTRY

X-ray structures of ferritins and related proteins

(2010) Robert R. Crichton et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The Ferritin-like superfamily: Evolution of the biological iron storeman from a rubrerythrin-like ancestor

(2010) Simon C. Andrews   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Enzymes with an heterodinuclear iron–manganese active site: Curiosity or necessity?

(2010) Michaël Carboni et al.   COORDINATION CHEMISTRY REVIEWS

Homologous expression of the nrdF gene of Corynebacterium ammoniagenes strain ATCC 6872 generates a manganese-metallocofactor (R2F) and a stable tyrosyl radical (Y•) involved in ribonucleotide reduction

(2010) Patrick Stolle et al.   FEBS Journal

The use of thiols by ribonucleotide reductase

(2010) Arne Holmgren et al.   FREE RADICAL BIOLOGY AND MEDICINE

Density Functional Theory Analysis of Structure, Energetics, and Spectroscopy for the Mn−Fe Active Site ofChlamydia trachomatisRibonucleotide Reductase in Four Oxidation States

(2010) Wen-Ge Han et al.   INORGANIC CHEMISTRY

A Tyrosyl−Dimanganese Coupled Spin System is the Native Metalloradical Cofactor of the R2F Subunit of the Ribonucleotide Reductase of Corynebacterium ammoniagenes

(2010) Nicholas Cox et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

Messy biology and the origins of evolutionary innovations

(2010) Dan S Tawfik   Nature Chemical Biology

A Never-Ending Story

(2010) B.-M. Sjoberg   SCIENCE

Structural Basis for Activation of Class Ib Ribonucleotide Reductase

(2010) A. K. Boal et al.   SCIENCE

Microbial Biosynthesis of Alkanes

(2010) A. Schirmer et al.   SCIENCE

Crystallization and preliminary X-ray analysis of the small subunit (R2F) of native ribonucleotide reductase fromCorynebacterium ammoniagenes

(2009) Hideaki Ogata et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Density Functional Theory Study of the Manganese-Containing Ribonucleotide Reductase fromChlamydia trachomatis: Why Manganese Is Needed in the Active Complex

(2009) Katarina Roos et al.   BIOCHEMISTRY

Metal Binding and Activity of Ribonucleotide Reductase Protein R2 Mutants: Conditions for Formation of the Mixed Manganese−Iron Cofactor

(2009) Ana Popović-Bijelić et al.   BIOCHEMISTRY

The ferritin superfamily: Supramolecular templates for materials synthesis

(2009) Masaki Uchida et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Understanding the influence of the protein environment on the Mn(II) centers in Superoxide Dismutases using High-Field Electron Paramagnetic Resonance

(2009) Leandro C. Tabares et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

RNRdb, a curated database of the universal enzyme family ribonucleotide reductase, reveals a high level of misannotation in sequences deposited to Genbank

(2009) Daniel Lundin et al.   BMC GENOMICS

Electron paramagnetic resonance (EPR) spectroscopy of the stable-free radical in the native metallo-cofactor of the manganese-ribonucleotide reductase (Mn-RNR) ofCorynebacterium glutamicum

(2009) Bouziane Abbouni et al.   FREE RADICAL RESEARCH

Desaturases: Emerging Models for Understanding Functional Diversification of Diiron-containing Enzymes

(2009) John Shanklin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The manganese/iron-carboxylate proteins: what is what, where are they, and what can the sequences tell us?

(2009) Martin Högbom   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Development of a generic approach to native metalloproteomics: application to the quantitative identification of soluble copper proteins in Escherichia coli

(2009) Ana-Maria Sevcenco et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Identification of Protonated Oxygenic Ligands of Ribonucleotide Reductase Intermediate X

(2009) Muralidharan Shanmugam et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metalloproteomics, metalloproteomes, and the annotation of metalloproteins

(2009) Wolfgang Maret   Metallomics

Manganese import is a key element of the OxyR response to hydrogen peroxide inEscherichia coli

(2009) Adil Anjem et al.   MOLECULAR MICROBIOLOGY

Metalloproteins and metal sensing

(2009) Kevin J. Waldron et al.   NATURE

A Mycobacterium tuberculosis ligand-binding Mn/Fe protein reveals a new cofactor in a remodeled R2-protein scaffold

(2009) C. S. Andersson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of ADP-ribosylation removal revealed by the structure and ligand complexes of the dimanganese mono-ADP-ribosylhydrolase DraG

(2009) C. L. Berthold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Carboxylate-Bridged Dinuclear Active Sites in Oxygenases: Diiron, Dimanganese, or is Heterodinuclear Better?

(2008) Arne Roth et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rapid and Quantitative Activation ofChlamydia trachomatisRibonucleotide Reductase by Hydrogen Peroxide†

(2008) Wei Jiang et al.   BIOCHEMISTRY

Branched Activation- and Catalysis-Specific Pathways for Electron Relay to the Manganese/Iron Cofactor in Ribonucleotide Reductase fromChlamydia trachomatis†

(2008) Wei Jiang et al.   BIOCHEMISTRY

Formation and Function of the Manganese(IV)/Iron(III) Cofactor inChlamydia trachomatisRibonucleotide Reductase†

(2008) Wei Jiang et al.   BIOCHEMISTRY

The Radical SAM Superfamily

(2008) Perry A. Frey et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

The manganese(IV)/iron(III) cofactor of Chlamydia trachomatis ribonucleotide reductase: structure, assembly, radical initiation, and evolution

(2008) J Martin Bollinger et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Redox Intermediates of the Mn-Fe Site in Subunit R2 ofChlamydia trachomatisRibonucleotide Reductase

(2008) Nina Voevodskaya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Analysis of the Mn(IV)/Fe(III) Cofactor of Chlamydia trachomatis Ribonucleotide Reductase by Extended X-ray Absorption Fine Structure Spectroscopy and Density Functional Theory Calculations

(2008) Jarod M. Younker et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Swapping metals in Fe- and Mn-dependent dioxygenases: Evidence for oxygen activation without a change in metal redox state

(2008) J. P. Emerson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA