Article
Biochemical Research Methods
Petra Tomasova, Petra Prochazkova, Radka Roubalova, Jiri Dvorak, Helena Tlaskalova-Hogenova, Martina Cermakova, Helena Pelantova, Blanka Sediva, Marek Vecka, Hana Papezova, Marek Kuzma
Summary: Metabolomic analysis reveals significant metabolic changes in patients with anorexia nervosa, highlighting the severity of system disruption and limited improvement after treatment.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Anna Maria Timperio, Federica Gevi, Francesca Cucinotta, Arianna Ricciardello, Laura Turriziani, Maria Luisa Scattoni, Antonio M. Persico
Summary: This study compares the urinary metabolomic differences between a child with idiopathic ASD and his/her typically-developing sibling, and highlights the involvement of purine and tryptophan pathways, as well as abnormalities in phenylalanine, tyrosine, and tryptophan pathways in ASD. It also emphasizes the excess of gut microbiota-derived compounds in ASD, which could have diagnostic value in differentiating the metabolome of autistic and unaffected siblings. Furthermore, it suggests the existence of a metabolic autism spectrum with unaffected siblings displaying an intermediate metabolic profile between autistic siblings and typically-developing controls.
Review
Pharmacology & Pharmacy
Abdul-Hamid Emwas, Kacper Szczepski, Inas Al-Younis, Joanna Izabela Lachowicz, Mariusz Jaremko
Summary: Fluxomics is an innovative research field that measures intracellular flux rates in biological systems, providing insights into molecular interactions and metabolic pathways. It has become increasingly relevant in studying metabolic phenotypes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Analytical
Krzysztof Ossolinski, Tomasz Ruman, Valerie Copie, Brian P. Tripet, Artur Kolodziej, Aneta Plaza-Altamer, Anna Ossolinska, Tadeusz Ossolinski, Anna Nieczaj, Joanna Niziol
Summary: This study investigated polar metabolite profiles in urine samples from BC patients and normal controls using NMR and LDI-MS and identified potential markers for bladder cancer. The metabolites were able to distinguish urine samples from BC and NCs individuals, and correlate with tumor stages and grades. The findings suggest that these metabolite markers may be useful for non-invasive detection and monitoring of bladder cancer.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Multidisciplinary Sciences
Nicholas J. J. Morehouse, Trevor N. N. Clark, Emily J. J. McMann, Jeffrey A. A. van Santen, F. P. Jake Haeckl, Christopher A. A. Gray, Roger G. G. Linington
Summary: Spectral matching of MS2 fragmentation spectra has limitations due to instrument differences and limited spectral reference libraries. To overcome this challenge, SNAP-MS uses structural similarity network annotation to assign compound families to molecular networking subnetworks without using experimental or calculated reference spectra. SNAP-MS accurately annotates subnetworks built from both reference spectra and an in-house microbial extract library, and predicts compound families from published molecular networks acquired using different MS instruments.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Jozsef Lenart, Attila Gere, Tim Causon, Stephan Hann, Mihaly Dernovics, Olga Nemeth, Attila Hegedus, Julia Halasz
Summary: This study aimed to identify metabolites playing crucial roles in sexual incompatibility reactions in apricot (Prunus armeniaca L.) using liquid chromatography coupled to time-of-flight mass spectrometry. The results showed significant differential compounds in self-compatible and self-incompatible apricot pistils, with a total explained variance of 89.55% in principal component analysis indicating high quality of differential expression analysis. The study suggested potential metabolites involved in the sexual incompatibility reactions, including polyketide-based macrolides and a hydroxy sphingosine derivative.
PLANT MOLECULAR BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Miguel Esperanca-Martins, Iola F. Duarte, Mara Rodrigues, Joaquim Soares do Brito, Dolores Lopez-Presa, Luis Costa, Isabel Fernandes, Sergio Dias
Summary: The prognosis of soft tissue sarcomas (STS) is disappointing due to the lack of individualized treatment strategies and the neglect of specificities and genetic/metabolic differences among sarcoma subtypes. There is a need for more studies to decipher the mechanisms of sarcomagenesis, improve STS diagnosis precision, refine STS classification criteria, and identify prognostic biomarkers. Metabolomics, either as a single-omics approach or as part of a multi-omics strategy, provides valuable insights into the metabolic adaptations that support sarcomagenesis. Further studies employing various data acquisition methods have provided important information for the characterization of the STS metabolome. New methods based on chromatography, mass spectrometry (MS), nuclear magnetic resonance (NMR) spectroscopy, and flow cytometry will offer opportunities to target metabolic pathways therapeutically and monitor the response to such therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Alessandro Di Minno, Monica Gelzo, Mariano Stornaiuolo, Margherita Ruoppolo, Giuseppe Castaldo
Summary: Untargeted Metabolomics and targeted Metabolomics have made significant progress in the field of life sciences, particularly in the discovery of biomarkers. Expertise in laboratory medicine and bioinformatics helps address challenges and biases in metabolite profiling. Clinical validation and profitability testing are essential steps in identifying potential biomarkers.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Review
Chemistry, Multidisciplinary
Micah J. Jeppesen, Robert Powers
Summary: Metabolomics samples contain thousands of metabolites, but single analytical techniques can only characterize a few hundred. This limitation can be overcome by using a multiplatform approach and employing synergistic sample preparation and multiple probabilistic methods for peak detection and metabolite identification. However, the analysis of large data sets from different analytical techniques presents challenges in data processing and requires the use of multivariate analysis methods.
MAGNETIC RESONANCE IN CHEMISTRY
(2023)
Review
Agriculture, Dairy & Animal Science
M. Ashokan, Ekta Rana, Kadimetla Sneha, C. Namith, G. S. Naveen Kumar, N. Azharuddin, K. Elango, S. Jeyakumar, K. P. Ramesha
Summary: Advancements in NMR and MS technologies, along with developments in omics sciences, have led to a better understanding of molecular mechanisms and pathways related to the physiological and pathological state of animals. Metabolomics, a post-genomics tool, provides valuable information about an organism's status by analyzing small molecular metabolites within a given time frame. Recently, researchers have focused on metabolomics studies in various fields of livestock management and precision dairying. This review aims to provide insights into the current research and application of metabolomics in different areas of livestock, including nutri-metabolomics, disease diagnosis advancements, reproductive disorders, pharmaco-metabolomics, genomics studies, and dairy production studies.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Chemistry, Physical
Efficient N. Ncube, Lungile Sitole, Paul A. Steenkamp, Lucia H. Steenkamp, Ian A. Dubery
Summary: In this study, metabolomics was used to investigate the basic metabolic capabilities of H. roseonigra. The results showed that the identified discriminatory ions fell predominantly in the primary metabolism class, and no terpene synthesis was flagged. This study provides novel insights into the biochemistry of H. roseonigra and has important implications for further research.
Article
Multidisciplinary Sciences
Changmeng Cui, Li Zhu, Qian Wang, Ruijuan Liu, Dadi Xie, Yujin Guo, Dingyi Yu, Changshui Wang, Dan Chen, Pei Jiang
Summary: The study investigated the metabolic changes after vancomycin administration in mice, revealing that vancomycin affects the metabolism in various organs, providing new insights for identification of vancomycin-induced toxicity.
Article
Chemistry, Analytical
Anna Rajska, Magdalena Buszewska-Forajta, Szymon Macioszek, Renata Wawrzyniak, Pawel Wityk, Andrzej Berg, Agnieszka Kowalewska, Dominik Rachon, Michal J. Markuszewski
Summary: Despite numerous studies, the cause of PCOS remains unknown. To confirm the reliability of proposed metabolomics biomarkers, we conducted a validation study on serum and urine samples from PCOS patients and healthy controls. Our analysis identified a comprehensive set of altered metabolites in PCOS patients, indicating disruptions in hormone synthesis, lipid metabolism, and energy production.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Vincent Hamani, Pascaline Ory, Pierre-Edouard Bodet, Laurence Murillo, Marianne Graber
Summary: This study investigated the impact of copper on the metabolism of the variegated scallop, identifying 28 metabolites clearly modulated by copper that reflect its effects on various biological functions such as osmoregulation, oxidative stress, reproduction, and energy metabolism.
Article
Biochemical Research Methods
Ruimin Wang, Miaoshan Lu, Shaowei An, Jinyin Wang, Changbin Yu
Summary: In this study, a novel deep learning-based model called 3D-MSNet was proposed for untargeted feature extraction in metabolomics research. Comparisons with nine popular software demonstrated that 3D-MSNet outperformed others in feature detection and quantification accuracy. Additionally, 3D-MSNet exhibited high feature extraction robustness and could be applied to profile MS data acquired with various high-resolution mass spectrometers.
Article
Automation & Control Systems
Miguel de Figueiredo, Stamatios Giannoukos, Cedric Wuethrich, Renato Zenobi, Douglas N. Rutledge
Summary: To analyze data from multifactorial experiments, methods like ANOVA-PCA, ANOVA-SCA, PARAFASCA, AMOPLS and AComDim can be used to model and decompose the main sources of variation. Among these methods, AComDim stands out for its ability to provide an overall understanding of all the sources of variation through a single model, making it suitable for complex data structures.
JOURNAL OF CHEMOMETRICS
(2023)
Article
Biochemical Research Methods
Marie H. Deventer, Katleen Van Uytfanghe, Inge M. J. Vinckier, Fabiano Reniero, Claude Guillou, Christophe P. Stove
Summary: In recent years, countries have implemented measures to control the increase of new synthetic cannabinoid receptor agonists (SCRAs) in the recreational drug market. China implemented a new legislation in July 2021, banning SCRAs with seven core scaffolds. This study reports on the potency and efficacy of five members of a new class of SCRAs, providing important information for public health officials, law enforcement agencies, and clinicians.
DRUG TESTING AND ANALYSIS
(2022)
Article
Microbiology
Aimee Parker, Stefano Romano, Rebecca Ansorge, Asmaa Aboelnour, Gwenaelle Le Gall, George M. Savva, Matthew G. Pontifex, Andrea Telatin, David Baker, Emily Jones, David Vauzour, Steven Rudder, L. Ashley Blackshaw, Glen Jeffery, Simon R. Carding
Summary: This study demonstrates that changes in the gut microbiota are associated with age-related chronic diseases, particularly inflammation affecting the brain and retina. Fecal microbiota transplantation can alter the gut microbiota composition and metabolic pathways. Transferring aged donor microbiota into young mice accelerates age-associated inflammation in the central nervous system and retina, along with increased intestinal barrier permeability, while transferring young donor microbiota reverses these effects.
Article
Biochemistry & Molecular Biology
Jorge Lopez-Tello, Zoe Schofield, Raymond Kiu, Matthew J. Dalby, Douwe van Sinderen, Gwenaelle Le Gall, Amanda N. Sferruzzi-Perri, Lindsay J. Hall
Summary: This study demonstrates that the bacterium Bifidobacterium breve UCC2003, a key member of the maternal gut microbiota, modulates maternal body adaptations, placental structure, and nutrient transporter capacity, with implications for fetal metabolism and growth.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Janine Wilkinson, Damilola Ajulo, Valeria Tamburrini, Gwenaelle Le Gall, Kristof Kimpe, Rene Holm, Peter Belton, Sheng Qi
Summary: Long acting injectables have gained attention for their potential in improving treatment effectiveness and adherence. Lipid-based formulations, including oil solutions and lipid-based nanoparticles, have shown clinical benefits in reducing relapses in patients with schizophrenia. This review focuses on the development of lipid-based long acting injectables, providing useful guidance for future product design and development.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Review
Automation & Control Systems
Delphine Jouan-Rimbaud Bouveresse, Douglas N. Rutledge
Summary: The multiblock method allows the simultaneous analysis of several data matrices. CCSWA is a method suitable for analyzing such data, and modifications can be made to improve the models and their interpretation.
JOURNAL OF CHEMOMETRICS
(2022)
Article
Biochemistry & Molecular Biology
Oxana Ye Rodionova, Alexey L. Pomerantsev, Douglas N. Rutledge
Summary: This study presents a kinetic modeling approach for the natural long-term aging of pharmaceutical substances and Diclofenac tablets. By using near-infrared spectra, the study proposes a generic degradation mechanism and approximates the NIR spectra of intermediates and products. The study focuses on tablets in blister packs, which is important for practical applications.
Article
Nutrition & Dietetics
Ikpidi Badji, France Caillavet, Marie Josephe Amiot
Summary: The promotion efforts by FAO to increase the consumption of pulses in France have resulted in an 8.4% increase in purchasing, with younger participants, urban residents, and lower-income households showing the highest increase. However, consumption still remains below the recommended level, indicating a need for more public information and education on the health and sustainability benefits of pulses.
FRONTIERS IN NUTRITION
(2023)
Review
Environmental Sciences
Meg-Anne Moriceau, German Cano-Sancho, MinJi Kim, Xavier Coumoul, Claude Emond, Juan-Pedro Arrebola, Jean-Philippe Antignac, Karine Audouze, Christophe Rousselle
Summary: Blood is widely used to monitor persistent organic pollutants (POPs), but the variability in the distribution of POPs between adipose tissue and serum is poorly understood. This review found high variability in the partition coefficients of POPs between adipose tissue and serum, with the number of halogen atoms and body mass index being key factors influencing the partitioning ratios.
Article
Food Science & Technology
Arnaud Lamy, Sandrine Costa, Celine Vial, Ikpidi Badji, Myriam Carrere, Pascaline Rollet, Marie Josephe Amiot
Summary: In France, the horsemeat market has been declining for 50 years and has become specialized. This study examines the drivers and practices of consumers and non-consumers to understand this decline and estimate market potential. Analyzing two sets of data, the results highlight the potential for sustainable horsemeat consumption, provided moral acceptance is considered. Horsemeat offers nutritional and environmental benefits and can serve as a sustainable alternative to beef consumption.
Article
Nutrition & Dietetics
Julia Baudry, Floriane Neves, Denis Lairon, Benjamin Alles, Brigitte Langevin, Josephine Brunin, Florine Berthy, Ina Danquah, Mathilde Touvier, Serge Hercberg, Marie-Josephe Amiot, Philippe Pointereau, Emmanuelle Kesse-Guyot
Summary: This study aimed to evaluate the associations between adherence to the Mediterranean diet and sustainability domains. The results showed that higher adherence to the Mediterranean diet was associated with higher nutritional quality and reduced environmental impact. However, it also increased monetary cost and pesticide exposure.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Biochemical Research Methods
Caitlyn Norman, Marie H. Deventer, Olivia Dremann, Robert Reid, Katleen Van Uytfanghe, Claude Guillou, Inge M. J. Vinckier, Niamh Nic Daeid, Alex Krotulski, Christophe P. Stove
Summary: The rapidly evolving synthetic cannabinoid receptor agonist (SCRA) market poses significant challenges for forensic scientists. A new SCRA compound, CH-PIATA, with new structural features, has emerged. This study describes the detection of CH-PIATA in the United States, Belgium, and Scottish prisons in 2022. Metabolites of CH-PIATA were identified, and the harm potential of this substance was evaluated.
DRUG TESTING AND ANALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Patricia Ancel, Jean Charles Martin, Elisa Doukbi, Marie Houssays, Pierre Gascon, Maud Righini, Frederic Matonti, Ljubica Svilar, Marie Valmori, Catherine Tardivel, Nicolas Venteclef, Jean Baptiste Julla, Jean Francois Gautier, Noemie Resseguier, Anne Dutour, Benedicte Gaborit
Summary: Diabetic retinopathy (DR) is a main cause of vision loss in the working-age population with diabetes. This study found metabolic and lipid changes in plasma samples from patients with DR, and identified deregulated pathways associated with the disease. Furthermore, specific signatures were found in different subgroups of DR. These findings provide a basis for potential plasma biomarkers and advancing personalized medicine for DR.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Richard Miallot, Virginie Millet, Anais Roger, Romain Fenouil, Catherine Tardivel, Jean-Charles Martin, Laetitia Shintu, Paul Berchard, Juliane Sousa Lanza, Bernard Malissen, Sandrine Henri, Sophie Ugolini, Aurelie Dutour, Pascal Finetti, Francois Bertucci, Jean-Yves Blay, Franck Galland, Philippe Naquet
Summary: The study found that pantethine can inhibit tumor growth by enhancing the function of the immune system. Pantethine can promote the polarization of myeloid and dendritic cells towards enhanced antigen presentation pathways and improve the development of CD8+ T cells with immune effector activity. However, immune cell exhaustion limits the therapeutic effect of pantethine.
LIFE SCIENCE ALLIANCE
(2023)
