Contextual inhibition of fatty acid synthesis by metformin involves glucose-derived acetyl-CoA and cholesterol in pancreatic tumor cells

Metformin: Multi-faceted protection against cancer

(2015) Sonia Del Barco et al.   Oncotarget

NTFD--a stand-alone application for the non-targeted detection of stable isotope-labeled compounds in GC/MS data

(2013) K. Hiller et al.   BIOINFORMATICS

Stable Isotope-Assisted Metabolomics for Network-Wide Metabolic Pathway Elucidation

(2012) Darren J. Creek et al.   ANALYTICAL CHEMISTRY

Fatty acids revert the inhibition of respiration caused by the antidiabetic drug metformin to facilitate their mitochondrial β-oxidation

(2012) M. Mar González-Barroso et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Metformin Prevents Liver Tumorigenesis by Inhibiting Pathways Driving Hepatic Lipogenesis

(2012) K. Bhalla et al.   Cancer Prevention Research

Metformin is synthetically lethal with glucose withdrawal in cancer cells

(2012) Javier A. Menendez et al.   CELL CYCLE

Metformin and Pancreatic Cancer: A Clue Requiring Investigation

(2012) M. Pollak   CLINICAL CANCER RESEARCH

Metformin Use Is Associated with Better Survival of Diabetic Patients with Pancreatic Cancer

(2012) N. Sadeghi et al.   CLINICAL CANCER RESEARCH

Metformin reverses hexokinase and phosphofructokinase downregulation and intracellular distribution in the heart of diabetic mice

(2012) Daniel Da Silva et al.   IUBMB LIFE

Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells

(2011) Vlad C. Sandulache et al.   CANCER

Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1

(2011) I. Ben Sahra et al.   CANCER RESEARCH

Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ

(2011) Diana Whitaker-Menezes et al.   CELL CYCLE

Cellular and molecular mechanisms of metformin: an overview

(2011) Benoit Viollet et al.   CLINICAL SCIENCE

Metformin Inhibits Nuclear Receptor TR4-Mediated Hepatic Stearoyl-CoA Desaturase 1 Gene Expression With Altered Insulin Sensitivity

(2011) E. Kim et al.   DIABETES

Lower Risk of Cancer in Patients on Metformin in Comparison With Those on Sulfonylurea Derivatives: Results from a large population-based follow-up study

(2011) R. Ruiter et al.   DIABETES CARE

Cancer mortality reduction and metformin: a retrospective cohort study in type 2 diabetic patients

(2011) S. Bo et al.   DIABETES OBESITY & METABOLISM

Diverse mechanisms of growth inhibition by luteolin, resveratrol, and quercetin in MIA PaCa-2 cells: a comparative glucose tracer study with the fatty acid synthase inhibitor C75

(2011) Diane M. Harris et al.   Metabolomics

Dual Inhibition of Tumor Energy Pathway by 2-Deoxyglucose and Metformin Is Effective against a Broad Spectrum of Preclinical Cancer Models

(2011) J.-H. Cheong et al.   MOLECULAR CANCER THERAPEUTICS

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

Targeting Cancer Cell Metabolism: The Combination of Metformin and 2-Deoxyglucose Induces p53-Dependent Apoptosis in Prostate Cancer Cells

(2010) I. Ben Sahra et al.   CANCER RESEARCH

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

(2010) Adem Kalender et al.   Cell Metabolism

Metformin and Cancer Occurrence in Insulin-Treated Type 2 Diabetic Patients

(2010) M. Monami et al.   DIABETES CARE

Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase

(2010) Carolyn Algire et al.   ENDOCRINE-RELATED CANCER

Fatty acid synthase as a potential therapeutic target in cancer

(2010) Richard Flavin et al.   Future Oncology

Phenotype and Genotype of Pancreatic Cancer Cell Lines

(2010) Emily L. Deer et al.   PANCREAS

Serum Fatty Acid Synthase as a Marker of Pancreatic Neoplasia

(2009) K. Walter et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Metformin Disrupts Crosstalk between G Protein-Coupled Receptor and Insulin Receptor Signaling Systems and Inhibits Pancreatic Cancer Growth

(2009) K. Kisfalvi et al.   CANCER RESEARCH

New Users of Metformin Are at Low Risk of Incident Cancer: A cohort study among people with type 2 diabetes

(2009) G. Libby et al.   DIABETES CARE

Dual modulation of both lipid oxidation and synthesis by peroxisome proliferator-activated receptor-γ coactivator-1α and -1β in cultured myotubes

(2009) Daniel O. Espinoza et al.   FASEB JOURNAL

Antidiabetic Therapies Affect Risk of Pancreatic Cancer

(2009) Donghui Li et al.   GASTROENTEROLOGY

Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells

(2009) Christian M. Metallo et al.   JOURNAL OF BIOTECHNOLOGY

Metformin associated lactic acidosis

(2009) E. Fitzgerald et al.   BMJ-British Medical Journal

Metformin attenuates the stimulatory effect of a high-energy diet on in vivo LLC1 carcinoma growth

(2008) C. Algire et al.   ENDOCRINE-RELATED CANCER

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE

Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro

(2008) James A. Dykens et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY