Journal
METABOLOMICS
Volume 9, Issue 1, Pages 202-212Publisher
SPRINGER
DOI: 10.1007/s11306-012-0439-z
Keywords
Colorectal cancer; Adenomatous polyps; Phospholipids; Mass spectrometry; Biomarkers
Categories
Funding
- National Nature Science Foundation of China [31070714]
- National High Technology Research and Development Program, China [2006AA02Z4A6]
- Science and Technology Program of Beijing Municipality [Z0006329000191]
- Fundamental Research Funds for the Central Universities [105566GK]
- Beijing NOVA Program [2005B47]
- Indiana University
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Colorectal cancer (CRC) is believed to progress through the adenoma-carcinoma sequence. The adenoma-carcinoma transition is an important window for early detection and intervention of CRC. In the present study, plasma samples from patients with CRC (n = 120), patients with adenomatous polyps (AP) (n = 120), and healthy controls (n = 120) were collected. Plasma phospholipid levels were analyzed with liquid chromatography-tandem mass spectrometry. It was found that the plasma levels of major lysophosphatidylcholine (LPC) species were gradationally decreased from healthy controls, AP to CRC subjects. A formula including total saturated LPCs, 18:2 LPC and sphingosylphosphorylcholine (SPC) yielded a sensitivity and specificity of 88.3 and 80 % for separating CRC from healthy controls. An optimized model with total saturated LPCs, 20:4 LPC and sphingomyelins (SM) as markers yielded a sensitivity and specificity of 89 and 80 % for separating AP from the healthy controls. Moreover, with SM, SPC and saturated LPCs as markers, a model was made to separate CRC from AP with the sensitivity and specificity of 90 and 92.5 %, respectively. These data indicate that the plasma choline-containing phospholipid levels represent potential biomarkers to distinguish between healthy controls, AP and CRC cases, implying their clinical usage in CRC and/or AP-CRC progression detection.
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